Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase Retraction in /10.3892/ol.2025.15143

Zhang,Ali; Wang,Quansheng; Han,Zhiqiang; Hu,Wei; Xi,Ling; Gao,Qinlei; Wang,Shixuan; Zhou,Jianfeng; Xu,Gang; Meng,Li; Chen,Gang; Ma,Ding

doi:10.3892/ol.2013.1385

August 2013 Volume 6 Issue 2

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August 2013 Volume 6 Issue 2

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Article

Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase

Retraction in: /10.3892/ol.2025.15143

Authors:
- Ali Zhang
- Quansheng Wang
- Zhiqiang Han
- Wei Hu
- Ling Xi
- Qinlei Gao
- Shixuan Wang
- Jianfeng Zhou
- Gang Xu
- Li Meng
- Gang Chen
- Ding Ma
View Affiliations / Copyright

Affiliations: Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Gynecologic Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Pages: 339-346
|
Published online on: June 7, 2013

https://doi.org/10.3892/ol.2013.1385
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Abstract

Several lines of evidence support an important role for Snail, a transcriptional factor, in breast cancer. Overexpression of Snail has been associated with breast cancer metastasis, although the specific role of Snail in the process remains unclear. To address this issue, the expression levels of Snail, RhoA and fibronectin, as well as MMP‑2, were reduced in the breast tumor cell lines MDA‑MB‑231 and MDA‑MB‑435S, and their biological responses were studied in vitro and in vivo. For the first time, it was observed that downregulated Snail expression is correlated with a significant inhibition of the expression and activity of RhoA GTPase, as well as MMP‑2. The present data provide evidence that Snail promotes tumor cell motility and angiogenesis which is mainly mediated through the regulation of RhoA activity. In conclusion, the present findings demonstrate a key regulatory role for Snail in breast tumor growth and progression.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase

Retraction in: /10.3892/ol.2025.15143

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Abstract

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