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August 2013 Volume 6 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro

  • Authors:
    • Yu Wang
    • Wen‑Kun Bai
    • E. Shen
    • Bing Hu
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, P.R. China
  • Pages: 495-498
    |
    Published online on: June 10, 2013
       https://doi.org/10.3892/ol.2013.1389
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Abstract

Combination therapy is used to optimize anticancer efficacy and reduce the toxicity and side‑effects of drugs upon systemic administration. Ultrasound (US) combined with microbubbles (UM) enhances the intracellular uptake of cytotoxic drugs by tumor cells, particularly drug‑resistant cells. In the present study, low‑frequency and low‑energy US (US irradiation conditions: frequency, 21 kHz; power density, 0.113 W/cm2; exposure time, 2 min at a duty cycle of 70%; and valid treatment time, 84 sec) were used in combination with microbubbles (100 µl/ml) to deliver mitoxantrone HCl (MIT) to DU145 cells. The results showed that UM did not change the cell viability in the short‑ or long‑term. However, UM statistically enhanced the therapeutic effects and up to 31.26±3.34% of the cells exposed to UM were permeabilized compared with 9.74±2.55% of cells in the control, when using calcein (MW, 622.53) as a fluorogenic marker. Notably, UM affected the migration capability of the DU145 cells at 6 h post‑treatment. In conclusion, the ultrasonic parameters used in the present study enhanced the chemotherapeutic effect and reduced the unwanted side‑effects of MIT.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Bai WK, Shen E and Hu B: Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro. Oncol Lett 6: 495-498, 2013.
APA
Wang, Y., Bai, W., Shen, E., & Hu, B. (2013). Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro. Oncology Letters, 6, 495-498. https://doi.org/10.3892/ol.2013.1389
MLA
Wang, Y., Bai, W., Shen, E., Hu, B."Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro". Oncology Letters 6.2 (2013): 495-498.
Chicago
Wang, Y., Bai, W., Shen, E., Hu, B."Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro". Oncology Letters 6, no. 2 (2013): 495-498. https://doi.org/10.3892/ol.2013.1389
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Bai WK, Shen E and Hu B: Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro. Oncol Lett 6: 495-498, 2013.
APA
Wang, Y., Bai, W., Shen, E., & Hu, B. (2013). Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro. Oncology Letters, 6, 495-498. https://doi.org/10.3892/ol.2013.1389
MLA
Wang, Y., Bai, W., Shen, E., Hu, B."Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro". Oncology Letters 6.2 (2013): 495-498.
Chicago
Wang, Y., Bai, W., Shen, E., Hu, B."Sonoporation by low‑frequency and low‑power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro". Oncology Letters 6, no. 2 (2013): 495-498. https://doi.org/10.3892/ol.2013.1389
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