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Article

Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer

  • Authors:
    • Avaniyapuram Kannan Murugan
    • Chongfei Yang
    • Mingzhao Xing
  • View Affiliations / Copyright

    Affiliations: Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21217, USA
  • Pages: 437-441
    |
    Published online on: June 11, 2013
       https://doi.org/10.3892/ol.2013.1391
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Abstract

Frequent somatic mutations in the GNA11, matrix metalloproteinase (MMP)27, FGD1, TRRAP and GRM3 genes have been reported in various types of human cancer, but whether these genes are mutated in thyroid cancer is not known. In the present study, a mutational analysis of these genes was performed in thyroid cancer cell lines and thyroid cancer samples. No GNA11 mutations were identified in the papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) and anaplastic thyroid cancer (ATC) samples. Additionally, no mutations were identified in the MMP27 gene, although three synonymous [C351T (N117N), C1089T (S363S) and G1227A (G409G)] single nucleotide polymorphisms (SNPs) were observed infrequently in ATC. No mutations were detected in the FGD1 gene, but two infrequent synonymous [T2091C (T697T) and A2136G (P712P)] SNPs were observed in PTC. Furthermore, no mutations were identified in TRRAP and GRM3, although a frequent synonymous SNP [G1323A (T441T)] and infrequent non-synonymous SNP [G1424A (G475D)] of GRM3 were observed in PTC. No mutation of these genes was observed in 12 cell lines derived from various types of thyroid cancer. The present study reports for the first time the mutational status of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer. No mutations were identified in these genes in the various types and cell lines of thyroid cancer. Therefore, unlike in other types of cancer, mutations in these genes are absent or uncommon in thyroid cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Murugan AK, Yang C and Xing M: Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer. Oncol Lett 6: 437-441, 2013.
APA
Murugan, A.K., Yang, C., & Xing, M. (2013). Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer. Oncology Letters, 6, 437-441. https://doi.org/10.3892/ol.2013.1391
MLA
Murugan, A. K., Yang, C., Xing, M."Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer". Oncology Letters 6.2 (2013): 437-441.
Chicago
Murugan, A. K., Yang, C., Xing, M."Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer". Oncology Letters 6, no. 2 (2013): 437-441. https://doi.org/10.3892/ol.2013.1391
Copy and paste a formatted citation
x
Spandidos Publications style
Murugan AK, Yang C and Xing M: Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer. Oncol Lett 6: 437-441, 2013.
APA
Murugan, A.K., Yang, C., & Xing, M. (2013). Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer. Oncology Letters, 6, 437-441. https://doi.org/10.3892/ol.2013.1391
MLA
Murugan, A. K., Yang, C., Xing, M."Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer". Oncology Letters 6.2 (2013): 437-441.
Chicago
Murugan, A. K., Yang, C., Xing, M."Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer". Oncology Letters 6, no. 2 (2013): 437-441. https://doi.org/10.3892/ol.2013.1391
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