Sarcomatoid carcinoma of the renal pelvis: Experience of multiple cases over a ten‑year period

Chen,Shanwen; Chen,Geming; Xia,Dan; Li,Jun; Wang,Shuo; Shen,Baihua; Jin,Baiye

doi:10.3892/ol.2013.1396

August 2013 Volume 6 Issue 2

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August 2013 Volume 6 Issue 2

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Article

Sarcomatoid carcinoma of the renal pelvis: Experience of multiple cases over a ten‑year period

Authors:
- Shanwen Chen
- Geming Chen
- Dan Xia
- Jun Li
- Shuo Wang
- Baihua Shen
- Baiye Jin
View Affiliations / Copyright

Affiliations: Department of Urology, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, Zhejiang 310031, P.R. China, Department of Pathology, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, Zhejiang 310031, P.R. China
Pages: 513-516
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Published online on: June 13, 2013

https://doi.org/10.3892/ol.2013.1396
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Abstract

Sarcomatoid carcinoma of the renal pelvis is a rare clinical entity. To the best of our knowledge, only 14 cases of this type of neoplasm have been reported in the literature to date. In the present study, the records at The First Affiliated Hospital, Medicine School of Zhejiang University (Hangzhou, Zhejiang, China) between 2000 and 2010 were reviewed to identify patients with primary renal pelvis sarcomatoid carcinoma (RPSC). A particular emphasis was placed on the treatment, recurrence and survival outcome. Eight patients with RPSC were identified and treated with nephrectomy or nephroureterectomy. All of the patients presented with Grade 3 RPSC. According to the TNM classification system, 2 patients were in stage pT2, 5 in stage pT3 and 1 in stage pT4. Adjuvant chemotherapy was administered to four patients, and the mean follow‑up period was 27.5±41.0 months. In total, 6 patients succumbed to the disease with a mean survival time of 7.7±5.3 months (range, 1-18 months), while 2 patients were free of disease at 54 and 120 months, respectively, following treatment. The mean disease-specific survival time was 27.5±41.0 months and the 1-year recurrence-free survival, 1-year survival and overall survival rates were 37.5, 37.5 and 25%, respectively. The present analysis suggests a poor prognosis for the majority of RPSC patients, most likely resulting from the advanced stage of the disease at diagnosis and a poor response to systemic therapy. To improve the survival rate of RPSC, it is therefore essential to perform an early diagnosis and early radical surgery. Intravesical instillation is not essential following surgery.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Sarcomatoid carcinoma of the renal pelvis: Experience of multiple cases over a ten‑year period

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