Osteolytic myxopapillary ependymoma with marked hyaline degeneration in a 72‑year‑old male: A case report

Wang,Hai; Zhang,Zhiyuan; Makki,Mohammad  Shahidul; Shi,Qunli

doi:10.3892/ol.2013.1397

August 2013 Volume 6 Issue 2

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August 2013 Volume 6 Issue 2

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Case Report

Osteolytic myxopapillary ependymoma with marked hyaline degeneration in a 72‑year‑old male: A case report

Authors:
- Hai Wang
- Zhiyuan Zhang
- Mohammad Shahidul Makki
- Qunli Shi
View Affiliations / Copyright

Affiliations: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, P.R. China, Department of Neurosurgery, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu 210002, P.R. China, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Pages: 487-489
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Published online on: June 14, 2013

https://doi.org/10.3892/ol.2013.1397
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Abstract

Myxopapillary ependymomas (MPEs) are uncommon and account for ~15% of all ependymomas. The current study presents a case of rare spinal MPE with abnormal hyaline degeneration. The patient was a 72‑year‑old male with a 10‑month history of lower back pain. Magnetic resonance imaging revealed a mass involving the L4 and L5 vertebrae with local bone destruction. The tumor was completely resected. Histologically, the majority of the tumor exhibited low cellularity. A marked change in hyaline was observed in the blood vessels and stroma. In specific areas, the tumor showed reticular or tubular patterning embedded in hyaline materials. The tumor cells were cuboidal to columnar in shape with strong immunostaining for glial fibrillary acidic protein and S‑100. A fluorescence in situ hybridization analysis for amplification of the epidermal growth factor receptor gene was negative. The results of pathological and immunohistochemical studies were consistent with the ependymal nature of neoplastic cells.

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1.	Bagley CA, Kothbauer KF, Wilson S, Bookland MJ, Epstein FJ and Jallo GI: Resection of myxopapillary ependymomas in children. J Neurosurg. 106(4 Suppl): 261–267. 2007.PubMed/NCBI
2.	Nakamura M, Ishii K, Watanabe K, et al: Long-term surgical outcomes for myxopapillary ependymomas of the cauda equina. Spine. (Phila Pa 1976). 34:E756–E760. 2009. View Article : Google Scholar : PubMed/NCBI
3.	Kulesza P, Tihan T and Ali SZ: Myxopapillary ependymoma: cytomorphologic characteristics and differential diagnosis. Diagn Cytopathol. 26:247–250. 2002. View Article : Google Scholar : PubMed/NCBI
4.	Zacharoulis S, Ji L, Pollack IF, et al: Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors. Pediatr Blood Cancer. 50:231–235. 2008. View Article : Google Scholar : PubMed/NCBI
5.	Verma A, Zhou H, Chin S, Bruggers C, Kestle J and Khatua S: EGFR as a predictor of relapse in myxopapillary ependymoma. Pediatr Blood Cancer. 59:746–748. 2012. View Article : Google Scholar : PubMed/NCBI
6.	Tseng YC, Hsu HL, Jung SM and Chen CJ: Primary intracranial myxopapillary ependymomas: report of two cases and review of the literature. Acta Radiol. 45:344–347. 2004. View Article : Google Scholar : PubMed/NCBI
7.	Lee KJ, Min BW, Seo HJ and Cho CH: Subcutaneous sacrococcygeal myxopapillary ependymoma in asian female: a case report. J Clin Med Res. 4:61–63. 2012.PubMed/NCBI
8.	Sato H, Ohmura K, Mizushima M, Ito J and Kuyama H: Myxopapillary ependymoma of the lateral ventricle. A study on the mechanism of its stromal myxoid change. Acta Pathol Jpn. 33:1017–1025. 1983.PubMed/NCBI
9.	Lim SC and Jang SJ: Myxopapillary ependymoma of the fourth ventricle. Clin Neurol Neurosurg. 108:211–214. 2006. View Article : Google Scholar : PubMed/NCBI
10.	Rawlinson DG, Herman MM and Rubinstein LJ: The fine structure of a myxopapillary ependymoma of the filum terminale. Acta Neuropathol. 25:1–13. 1973. View Article : Google Scholar : PubMed/NCBI
11.	Miller C: The ultrastructure of the conus medullaris and filum terminale. J Comp Neurol. 132:547–566. 1968. View Article : Google Scholar : PubMed/NCBI
12.	Matyja E, Naganska E, Zabek M and Koziara H: Myxopapillary ependymoma of the lateral ventricle with local recurrences: histopathological and ultrastructural analysis of a case. Folia Neuropathol. 41:51–57. 2003.
13.	Estrozi B, Queiroga E, Bacchi CE, et al: Myxopapillary ependymoma of the posterior mediastinum. Ann Diagn Pathol. 10:283–287. 2006. View Article : Google Scholar : PubMed/NCBI
14.	Stern JB and Helwig EB: Ultrastructure of subcutaneous sacrococcygeal myxopapillary ependymoma. Arch Pathol Lab Med. 105:524–526. 1981.PubMed/NCBI
15.	Kindblom LG, Lodding P, Hagmar B and Stenman G: Metastasizing myxopapillary ependymoma of the sacrococcygeal region. A clinico-pathologic, light- and electronmicroscopic, immunohistochemical, tissue culture, and cytogenetic analysis of a case. Acta Pathol Microbiol Immunol Scand A. 94:79–90. 1986.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Osteolytic myxopapillary ependymoma with marked hyaline degeneration in a 72‑year‑old male: A case report

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