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August 2013 Volume 6 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway

  • Authors:
    • Hongmin Shao
    • Baowen Yang
    • Rongrong Hu
    • Yingying Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. China
  • Pages: 517-520
    |
    Published online on: June 14, 2013
       https://doi.org/10.3892/ol.2013.1399
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Abstract

Matrine is an alkaloid isolated from Sophora flavescens. The present study aimed to determine whether matrine effectively inhibits the proliferation of breast cancer cells, and the underlying mechanism(s) of its antitumor function. The effects of matrine on the cell viability of ER‑positive MCF7 cells, HER2‑positive BT‑474 cells and highly metastatic MDA‑MB‑231 cells were measured using MTT and apoptosis assays. Western blot analysis was performed to investigate the expression levels of the inhibitor of κB (IκB) kinase β (IKKβ) in cells treated with or without matrine. It was observed that the matrine treatment resulted in the death of the three types of cancer cells, but significantly less toxicity was observed in the control cancer cells. The experimental results also suggested that the antitumor effects of matrine on breast cancer cells may be associated with the downregulation of IKKβ expression by matrine, as indicated by the western blot analysis results. The present results suggested that matrine may be used as an effective drug candidate for treating breast cancers in the future, following further research.
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Copy and paste a formatted citation
Spandidos Publications style
Shao H, Yang B, Hu R and Wang Y: Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway. Oncol Lett 6: 517-520, 2013.
APA
Shao, H., Yang, B., Hu, R., & Wang, Y. (2013). Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway. Oncology Letters, 6, 517-520. https://doi.org/10.3892/ol.2013.1399
MLA
Shao, H., Yang, B., Hu, R., Wang, Y."Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway". Oncology Letters 6.2 (2013): 517-520.
Chicago
Shao, H., Yang, B., Hu, R., Wang, Y."Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway". Oncology Letters 6, no. 2 (2013): 517-520. https://doi.org/10.3892/ol.2013.1399
Copy and paste a formatted citation
x
Spandidos Publications style
Shao H, Yang B, Hu R and Wang Y: Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway. Oncol Lett 6: 517-520, 2013.
APA
Shao, H., Yang, B., Hu, R., & Wang, Y. (2013). Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway. Oncology Letters, 6, 517-520. https://doi.org/10.3892/ol.2013.1399
MLA
Shao, H., Yang, B., Hu, R., Wang, Y."Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway". Oncology Letters 6.2 (2013): 517-520.
Chicago
Shao, H., Yang, B., Hu, R., Wang, Y."Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF‑κB signaling pathway". Oncology Letters 6, no. 2 (2013): 517-520. https://doi.org/10.3892/ol.2013.1399
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