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August 2013 Volume 6 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement

  • Authors:
    • Xinglai Fen
    • Weifeng Qin
    • Wuan Bao
    • Feng Jiang
    • Bin Li
    • Fujun Hu
    • Xiaozhong Chen
  • View Affiliations / Copyright

    Affiliations: Radiation Therapy Department of Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 427-431
    |
    Published online on: June 17, 2013
       https://doi.org/10.3892/ol.2013.1407
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Abstract

The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. Primary tumor volume was reduced by 42.76% after 2 doses of interventional chemotherapy and intracranial tumor volume was reduced by 55.63%. All patients presented grade II and above nasopharyngeal mucositis. In the 2 years following radiotherapy, overall survival (OS) was 83.3% and progression-free survival (PFS) was 75%. In conclusion, T4 NPC patients with intracranial extension received induction chemotherapy followed by IMRT and concurrent chemotherapy, which proved to be efficacious and well tolerated.
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Copy and paste a formatted citation
Spandidos Publications style
Fen X, Qin W, Bao W, Jiang F, Li B, Hu F and Chen X: Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement. Oncol Lett 6: 427-431, 2013.
APA
Fen, X., Qin, W., Bao, W., Jiang, F., Li, B., Hu, F., & Chen, X. (2013). Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement. Oncology Letters, 6, 427-431. https://doi.org/10.3892/ol.2013.1407
MLA
Fen, X., Qin, W., Bao, W., Jiang, F., Li, B., Hu, F., Chen, X."Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement". Oncology Letters 6.2 (2013): 427-431.
Chicago
Fen, X., Qin, W., Bao, W., Jiang, F., Li, B., Hu, F., Chen, X."Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement". Oncology Letters 6, no. 2 (2013): 427-431. https://doi.org/10.3892/ol.2013.1407
Copy and paste a formatted citation
x
Spandidos Publications style
Fen X, Qin W, Bao W, Jiang F, Li B, Hu F and Chen X: Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement. Oncol Lett 6: 427-431, 2013.
APA
Fen, X., Qin, W., Bao, W., Jiang, F., Li, B., Hu, F., & Chen, X. (2013). Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement. Oncology Letters, 6, 427-431. https://doi.org/10.3892/ol.2013.1407
MLA
Fen, X., Qin, W., Bao, W., Jiang, F., Li, B., Hu, F., Chen, X."Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement". Oncology Letters 6.2 (2013): 427-431.
Chicago
Fen, X., Qin, W., Bao, W., Jiang, F., Li, B., Hu, F., Chen, X."Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement". Oncology Letters 6, no. 2 (2013): 427-431. https://doi.org/10.3892/ol.2013.1407
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