Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement

Fen,Xinglai; Qin,Weifeng; Bao,Wuan; Jiang,Feng; Li,Bin; Hu,Fujun; Chen,Xiaozhong

doi:10.3892/ol.2013.1407

Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement

Authors:
- Xinglai Fen
- Weifeng Qin
- Wuan Bao
- Feng Jiang
- Bin Li
- Fujun Hu
- Xiaozhong Chen
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Affiliations: Radiation Therapy Department of Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
Published online on: June 17, 2013 https://doi.org/10.3892/ol.2013.1407
Pages: 427-431

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Abstract

The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. Primary tumor volume was reduced by 42.76% after 2 doses of interventional chemotherapy and intracranial tumor volume was reduced by 55.63%. All patients presented grade II and above nasopharyngeal mucositis. In the 2 years following radiotherapy, overall survival (OS) was 83.3% and progression-free survival (PFS) was 75%. In conclusion, T4 NPC patients with intracranial extension received induction chemotherapy followed by IMRT and concurrent chemotherapy, which proved to be efficacious and well tolerated.

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