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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August 2013 Volume 6 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis

  • Authors:
    • Hong Zhu
    • Tian‑Cong Wu
    • Wei‑Qiong Chen
    • Li‑Jun Zhou
    • Yue Wu
    • Liang Zeng
    • Hai‑Ping Pei
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Pathology, Hunan Tumor Hospital, Changsha, Hunan 410013, P.R. China, Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 353-358
    |
    Published online on: June 18, 2013
       https://doi.org/10.3892/ol.2013.1414
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Abstract

Left-sided colon carcinoma (LSCC) and right‑sided colon carcinoma (RSCC) differ in their genetic susceptibilities to neoplastic transformation. The present study identified 11 genes that were differentially expressed in LSCC and RSCC by expression profiling with microarray analysis. Compared with RSCC, the human genes for L‑lactate dehydrogenase B chain (LDHB), cyclin‑dependent kinase 4 inhibitor D (CDKN2D), phosphatidylinositol‑4‑phosphate‑3‑kinase C2 domain‑containing subunit α (PI3KC2α), protocadherin fat 1 (FAT; a human protein that closely resembles the Drosophila tumor suppressor, fat) and dual specificity protein phosphatase 2 (DUSP2) were upregulated in LSCC. By contrast, genes for ubiquitin D (UBD), casein kinase‑1 binding protein (CK1BP), synaptotagmin‑13 (SYT1), zinc finger protein 560 (ZNF560), pleckstrin homology domain-containing family B member 2 (PLEKHB2) and IgGFc‑binding protein (FCGBP) were downregulated in LSCC compared with RSCC. A quantitative polymerase chain reaction (qPCR) analysis revealed that the mRNA levels of UBD and CK1BP in LSCC were significantly lower compared with those in RSCC (P=0.033 and P=0.005, respectively), whereas the mRNA levels of LDHB and CDKN2D in LSCC were significantly higher compared with those in RSCC (P=0.008 and P=0.017, respectively). Western blot and immunohistochemical analyses demonstrated that the expression of CDKN2D in LSCC was significantly higher compared with that in RSCC, while the expression of UBD in LSCC was significantly lower compared with that in RSCC. The present study provides important insights into the understanding of the molecular genetic basis for the different biological behaviors observed between LSCC and RSCC. These insights may therefore serve as a basis for the identification of novel colon cancer markers and therapeutic targets.
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1. 

Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar

2. 

Zhang S, Cui Y, Weng Z, Gong X, Chen M and Zhong B: Changes on the disease pattern of primary colorectal cancers in Southern China: a retrospective study of 20 years. Int J Colorectal Dis. 24:943–949. 2009.PubMed/NCBI

3. 

Jiang SX, Wang XS, Geng CH and Wang GY: Altering trend of clinical characteristics of colorectal cancer: a report of 3,607 cases. Ai Zheng. 28:54–56. 2009.PubMed/NCBI

4. 

Suttie SA, Shaikh I, Mullen R, Amin AI, Daniel T and Yalamarthi S: Outcome of right- and left-sided colonic and rectal cancer following surgical resection. Colorectal Dis. 13:884–889. 2011. View Article : Google Scholar

5. 

Bufill JA: Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med. 113:779–788. 1990. View Article : Google Scholar : PubMed/NCBI

6. 

Elnatan J, Goh HS and Smith DR: C-KI-RAS activation and the biological behaviour of proximal and distal colonic adenocarcinomas. Eur J Cancer. 32A:491–497. 1996. View Article : Google Scholar : PubMed/NCBI

7. 

Bell SM, Scott N, Cross D, et al: Prognostic value of p53 over-expression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology. 104:57–64. 1993.PubMed/NCBI

8. 

Breivik J, Meling GI, Spurkland A, Rognum TO and Gaudernack G: K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location. Br J Cancer. 69:367–371. 1994. View Article : Google Scholar : PubMed/NCBI

9. 

Thibodeau SN, Bren G and Schaid D: Microsatellite instability in cancer of the proximal colon. Science. 260:816–819. 1993. View Article : Google Scholar : PubMed/NCBI

10. 

Christodoulidis G, Spyridakis M, Symeonidis D, Kapatou K and Manolakis A: Clinicopathological differences between right- and left-sided colonic tumors and impact upon survival. Tech Coloproctol. 14(Suppl 1): S45–S47. 2010. View Article : Google Scholar : PubMed/NCBI

11. 

Wray CM, Ziogas A, Hinojosa MW, Le H, Stamos MJ and Zell JA: Tumor subsite location within the colon is prognostic for survival after colon cancer diagnosis. Dis Colon Rectum. 52:1359–1366. 2009. View Article : Google Scholar : PubMed/NCBI

12. 

Benedix F, Kube R, Meyer F, Schmidt U, Gastinger I and Lippert H; Colon/Rectum Carcinomas (Primary Tumor) Study Group: Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Dis Colon Rectum. 53:57–64. 2010. View Article : Google Scholar

13. 

Papagiorgis P, Oikonomakis I, Karapanagiotou I, Wexner SD and Nikiteas N: The impact of tumor location on the histopathologic expression of colorectal cancer. J BUON. 11:317–321. 2006.PubMed/NCBI

14. 

Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J and Speed TP: Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucl Acids Res. 30:e152002. View Article : Google Scholar : PubMed/NCBI

15. 

Koo CL, Kok LF, Lee MY, et al: Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study. J Transl Med. 7:252009.

16. 

Li Y, Basang Z, Ding H, et al: Latexin expression is down-regulated in human gastric carcinomas and exhibits tumor suppressor potential. BMC Cancer. 11:1212011. View Article : Google Scholar : PubMed/NCBI

17. 

Roh SS, Lee MH, Hwang YL, et al: Stimulation of the extra-cellular matrix production in dermal fibroblasts by velvet antler extract. Ann Dermatol. 22:173–179. 2010. View Article : Google Scholar : PubMed/NCBI

18. 

Griffini P, Freitas I, Vigorelli E and Van Noorden CJ: Changes in the zonation of lactate activity in lobules of rat liver after experimentally induced colon carcinoma metastases. Anticancer Res. 14:2537–2540. 1994.PubMed/NCBI

19. 

Sherr CJ and Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512. 1999. View Article : Google Scholar : PubMed/NCBI

20. 

Yan DW, Li DW, Yang YX, et al: Ubiquitin D is correlated with colon cancer progression and predicts recurrence for stage II–III disease after curative surgery. Br J Cancer. 103:961–969. 2010.PubMed/NCBI

21. 

O’Donovan N, Fischer A, Abdo EM, et al: Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. J Endocrinol. 174:517–524. 2002.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu H, Wu TC, Chen WQ, Zhou LJ, Wu Y, Zeng L and Pei HP: Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis. Oncol Lett 6: 353-358, 2013.
APA
Zhu, H., Wu, T., Chen, W., Zhou, L., Wu, Y., Zeng, L., & Pei, H. (2013). Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis. Oncology Letters, 6, 353-358. https://doi.org/10.3892/ol.2013.1414
MLA
Zhu, H., Wu, T., Chen, W., Zhou, L., Wu, Y., Zeng, L., Pei, H."Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis". Oncology Letters 6.2 (2013): 353-358.
Chicago
Zhu, H., Wu, T., Chen, W., Zhou, L., Wu, Y., Zeng, L., Pei, H."Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis". Oncology Letters 6, no. 2 (2013): 353-358. https://doi.org/10.3892/ol.2013.1414
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu H, Wu TC, Chen WQ, Zhou LJ, Wu Y, Zeng L and Pei HP: Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis. Oncol Lett 6: 353-358, 2013.
APA
Zhu, H., Wu, T., Chen, W., Zhou, L., Wu, Y., Zeng, L., & Pei, H. (2013). Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis. Oncology Letters, 6, 353-358. https://doi.org/10.3892/ol.2013.1414
MLA
Zhu, H., Wu, T., Chen, W., Zhou, L., Wu, Y., Zeng, L., Pei, H."Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis". Oncology Letters 6.2 (2013): 353-358.
Chicago
Zhu, H., Wu, T., Chen, W., Zhou, L., Wu, Y., Zeng, L., Pei, H."Screening for differentially expressed genes between left‑ and right‑sided colon carcinoma by microarray analysis". Oncology Letters 6, no. 2 (2013): 353-358. https://doi.org/10.3892/ol.2013.1414
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