Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August 2013 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 2013 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study

  • Authors:
    • Mauro Gacci
    • Nicola Tosi
    • Gianni Vittori
    • Andrea Minervini
    • Giovanni  Corona
    • Tommaso Cai
    • Anna Maria Morelli
    • Linda Vignozzi
    • Sergio Serni
    • Mario Maggi
    • Marco Carini
  • View Affiliations / Copyright

    Affiliations: Department of Urology, University of Florence, Florence, Italy, Endocrinology Unit, Maggiore‑Bellaria Hospital, Bologna, Italy, Department of Urology, Santa Chiara Regional Hospital, Trento, Italy, Department of Clinical Physiopathology, University of Florence, Florence, Italy
  • Pages: 529-533
    |
    Published online on: June 21, 2013
       https://doi.org/10.3892/ol.2013.1420
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The changes in testosterone and gonadotropin levels in patients who have undergone radical prostatectomy (RP) for clinically localized prostate cancer (PCa) remain unclear. The aim of the present study was to prospectively evaluate the changes in serum testosterone (Te), luteinizing hormone (LH) and follicle‑stimulating hormone (FSH) levels in the early months after RP for PCa and the correlation between these hormones at various follow‑up times. A total of 100 male patients with clinically localized PCa were consecutively included in the study. The serum levels of Te, LH and FSH were measured prior to RP (baseline) and at 1 and 3 months post‑operatively. Changes in the levels of Te, LH and FSH between the baseline and at 1 and 3 months after RP were analyzed with paired sample t‑tests. The correlations between LH and Te levels at the various follow‑up times were evaluated with a Spearman's rank correlation coefficient. At 1 month subsequent to RP, the Te levels were significantly decreased (baseline vs. 1 month, P=0.021) and subsequently recovered to the pre‑operative value at 3 months (baseline vs. 3 months, P=0.372). The mean Te level at baseline was 15.3 nmol/l, while at 1 and 3 months it was 13.8 and 14.4 nmol/l, respectively. By contrast, the levels of LH and FSH were significantly increased at 1 and 3 months post‑surgery, compared with the baseline value (baseline vs. 1 or 3 months, P<0.0001). The pre‑operative correlation between LH and Te was lost 1 month after RP and recovered after 3 months. Notably, the LH level at 1 month was markedly correlated with the Te levels recorded after 3 months. In the present study, patients developed compensated hypergonadotropic hypogonadism 3 months after RP.
View Figures

Figure 1

Figure 2

View References

1. 

Gacci M, Eardley I, Giuliano F, Hatzichristou D, Kaplan SA, Maggi M, McVary KT, Mirone V, Porst H and Roehrborn CG: Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol. 60:809–825. 2011. View Article : Google Scholar

2. 

Lowe FC: Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: sexual function. BJU Int. 95(Suppl 4): 12–18. 2005. View Article : Google Scholar

3. 

Khera M: Androgens and erectile function: a case for early androgen use in postprostatectomy hypogonadal men. J Sex Med. 6(Suppl 3): 234–238. 2009. View Article : Google Scholar : PubMed/NCBI

4. 

Gacci M, Corona G, Apolone G, Lanciotti M, Tosi N, Giancane S, Masieri L, Serni S, Maggi M and Carini M: Influence of serum testosterone on urinary continence and sexual activity in patients undergoing radical prostatectomy for clinically localized prostate cancer. Prostate Cancer Prostatic Dis. 13:168–172. 2010. View Article : Google Scholar

5. 

Gacci M, Ierardi A, Rose AD, Tazzioli S, Scapaticci E, Filippi S, Maggi M, Nicita G, Carini M and Montorsi F: Vardenafil can improve continence recovery after bilateral nerve sparing prostatectomy: results of a randomized, double blind, placebo-controlled pilot study. J Sex Med. 7:234–243. 2010. View Article : Google Scholar

6. 

Yamamoto S, Yonese J, Kawakami S, Ohkubo Y, Tatokoro M, Komai Y, Takeshita H, Ishikawa Y and Fukui I: Preoperative serum testosterone level as an independent predictor of treatment failure following radical prostatectomy. Eur Urol. 52:696–701. 2007. View Article : Google Scholar

7. 

Isom-Batz G, Bianco FJ Jr, Kattan MW, Mulhall JP, Lilja H and Eastham JA: Testosterone as a predictor of pathological stage in clinically localized prostate cancer. J Urol. 173:1935–1937. 2005. View Article : Google Scholar : PubMed/NCBI

8. 

Lane BR, Stephenson AJ, Magi-Galluzzi C, Lakin MM and Klein EA: Low testosterone and risk of biochemical recurrence and poorly differentiated prostate cancer at radical prostatectomy. Urology. 72:1240–1245. 2008. View Article : Google Scholar : PubMed/NCBI

9. 

Miller LR, Partin AW, Chan DW, Bruzek DJ, Dobs AS, Epstein JI and Walsh PC: Influence of radical prostatectomy on serum hormone levels. J Urol. 160:449–453. 1998. View Article : Google Scholar : PubMed/NCBI

10. 

Olsson M, Ekström L, Schulze J, Kjellman A, Akre O, Rane A and Gustafsson O: Radical prostatectomy: influence on serum and urinary androgen levels. Prostate. 70:200–205. 2010.PubMed/NCBI

11. 

Lackner JE, Maerk I, Koller A, Bieglmayer C, Marberger M, Kratzik C and Schatzl G: Serum inhibin - not a cause of low testosterone levels in hypogonadal prostate cancer? Urology. 72:1121–1124. 2008. View Article : Google Scholar : PubMed/NCBI

12. 

Madersbacher S, Schatzl G, Bieglmayer C, Reiter WJ, Gassner C, Berger P, Zidek T and Marberger M: Impact of radical prostatectomy and TURP on the hypothalamic-pituitary-gonadal hormone axis. Urology. 60:869–874. 2002. View Article : Google Scholar : PubMed/NCBI

13. 

Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP and Zattoni F: European Association of Urology: EAU guidelines on prostate cancer. Eur Urol. 53:68–80. 2008. View Article : Google Scholar : PubMed/NCBI

14. 

Carini M, Masieri L, Minervini A, Lapini A and Serni S: Oncological and functional results of antegrade radical retropubic prostatectomy for the treatment of clinically localised prostate cancer. Eur Urol. 53:554–561. 2008. View Article : Google Scholar

15. 

Corona G, Boddi V, Lotti F, Gacci M, Carini M, De Vita G, Sforza A, Forti G, Mannucci E and Maggi M: The relationship of testosterone to prostate-specific antigen in men with sexual dysfunction. J Sex Med. 7:284–292. 2010. View Article : Google Scholar : PubMed/NCBI

16. 

Sasagawa I, Nakada T, Suzuki H, Adachi Y and Adachi M: Effect of transurethral resection of prostate on plasma hormone levels in benign prostatic hyperplasia. Br J Urol. 72:611–614. 1993. View Article : Google Scholar : PubMed/NCBI

17. 

Türkölmez K, Bozlu M, Sarica K, Gemalmaz H, Ozdiler E and Gögüş O: Effects of transurethral prostate resection and transurethral laser prostatectomy on plasma hormone levels. Urol Int. 61:162–167. 1998.PubMed/NCBI

18. 

Reyes JG, Farias JG, Henríquez-Olavarrieta S, Madrid E, Parraga M, Zepeda AB and Moreno RD: The hypoxic testicle: physiology and pathophysiology. Oxid Med Cell Longev. 2012:9292852012. View Article : Google Scholar : PubMed/NCBI

19. 

Vignozzi L, Filippi S, Morelli A, Marini M, Chavalmane A, Fibbi B, Silvestrini E, Mancina R, Carini M, Vannelli GB, Forti G and Maggi M: Cavernous neurotomy in the rat is associated with the onset of an overt condition of hypogonadism. J Sex Med. 6:1270–1283. 2009. View Article : Google Scholar : PubMed/NCBI

20. 

Daniell HW, Clark JC, Pereira SE, Niazi ZA, Ferguson DW, Dunn SR, Figueroa ML and Stratte PT: Hypogonadism following prostate-bed radiation therapy for prostate carcinoma. Cancer. 91:1889–1895. 2001. View Article : Google Scholar : PubMed/NCBI

21. 

Gacci M, Simonato A, Masieri L, Gore JL, Lanciotti M, Mantella A, Rossetti MA, Serni S, Varca V, Romagnoli A, Ambruosi C, Venzano F, Esposito M, Montanaro T, Carmignani G and Carini M: Urinary and sexual outcomes in long-term (5+ years) prostate cancer disease free survivors after radical prostatectomy. Health Qual Life Outcomes. 7:942009.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gacci M, Tosi N, Vittori G, Minervini A, Corona G, Cai T, Morelli AM, Vignozzi L, Serni S, Maggi M, Maggi M, et al: Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study. Oncol Lett 6: 529-533, 2013.
APA
Gacci, M., Tosi, N., Vittori, G., Minervini, A., Corona, G., Cai, T. ... Carini, M. (2013). Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study. Oncology Letters, 6, 529-533. https://doi.org/10.3892/ol.2013.1420
MLA
Gacci, M., Tosi, N., Vittori, G., Minervini, A., Corona, G., Cai, T., Morelli, A. M., Vignozzi, L., Serni, S., Maggi, M., Carini, M."Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study". Oncology Letters 6.2 (2013): 529-533.
Chicago
Gacci, M., Tosi, N., Vittori, G., Minervini, A., Corona, G., Cai, T., Morelli, A. M., Vignozzi, L., Serni, S., Maggi, M., Carini, M."Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study". Oncology Letters 6, no. 2 (2013): 529-533. https://doi.org/10.3892/ol.2013.1420
Copy and paste a formatted citation
x
Spandidos Publications style
Gacci M, Tosi N, Vittori G, Minervini A, Corona G, Cai T, Morelli AM, Vignozzi L, Serni S, Maggi M, Maggi M, et al: Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study. Oncol Lett 6: 529-533, 2013.
APA
Gacci, M., Tosi, N., Vittori, G., Minervini, A., Corona, G., Cai, T. ... Carini, M. (2013). Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study. Oncology Letters, 6, 529-533. https://doi.org/10.3892/ol.2013.1420
MLA
Gacci, M., Tosi, N., Vittori, G., Minervini, A., Corona, G., Cai, T., Morelli, A. M., Vignozzi, L., Serni, S., Maggi, M., Carini, M."Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study". Oncology Letters 6.2 (2013): 529-533.
Chicago
Gacci, M., Tosi, N., Vittori, G., Minervini, A., Corona, G., Cai, T., Morelli, A. M., Vignozzi, L., Serni, S., Maggi, M., Carini, M."Changes in sex hormone levels after radical prostatectomy: Results of a longitudinal cohort study". Oncology Letters 6, no. 2 (2013): 529-533. https://doi.org/10.3892/ol.2013.1420
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team