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Article

Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution

  • Authors:
    • Keizo Yamaguchi
    • Yutaka Ogata
    • Yoshito Akagi
    • Kazuo Shirouzu
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan
  • Pages: 659-666
    |
    Published online on: July 1, 2013
       https://doi.org/10.3892/ol.2013.1433
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Abstract

Although post‑operative adjuvant chemotherapy (ACT) is only recommended for patients with stage II colon cancer who are at a high risk of recurrence, the definition of high risk remains unclear. The present study aimed to identify the risk factors for recurrence, which may also be indicators for adjuvant therapy, using a retrospective analysis of clinicopathological data obtained from stage II colon cancer patients who had undergone a curative resection. The present study also investigated the effects of ACT in patients who displayed the risk factors for recurrence. Univariate and multivariate analyses of the data collected from 377 stage II colon cancer patients, treated at Kurume University Hospital (Fukuoka, Japan) between 1982 and 2005, was conducted in order to determine and compare the risk factors for recurrence between the 163 patients who had undergone adjuvant therapy and the 214 patients who had not undergone adjuvant therapy. The risk factors for recurrence in patients who had not undergone adjuvant therapy were a serum carcinoembryonic antigen (CEA) level that was twice the cut‑off value and pre‑operative bowel obstruction. Adjuvant therapy provided no benefit to patients who presented with neither risk factor, but significantly decreased the recurrence rate in patients presenting with one or both risk factors. Based on these findings, serum CEA levels of twice the cut‑off value and pre‑operative bowel obstruction were proposed as indicators in the assessment for adjuvant chemotherapy following a curative resection for stage II colon cancer. These results warrant further clinical study of ACT in patients with one or both risk factors.
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1 

No authors listed. Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer: International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators. J Clin Oncol. 17:1356–1363. 1999.PubMed/NCBI

2 

Moertel CG, Fleming TR, Macdonald JS, et al: Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes’ B2 colon cancer. J Clin Oncol. 13:2936–2943. 1995.PubMed/NCBI

3 

Benson AB 3rd, Schrag D, Somerfield MR, et al: American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol. 22:3408–3419. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Labianca R, Nordlinger B, Beretta GD, Brouquet A and Cervantes A; ESMO Guidelines Working Group. Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up. Ann Oncol. 21(Suppl 5): v70–v77. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Watanabe T, Itabashi M, Shimada Y, et al; Japanese Society for Cancer of the Colon and Rectum. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Oncol. 1–29. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sato H, Maeda K, Sugihara K, et al: High-risk stage II colon cancer after curative resection. J Surg Oncol. 104:45–52. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Ogata Y, Murakami H, Sasatomi T, et al: Elevated preoperative serum carcinoembrionic antigen level may be an effective indicator for needing adjuvant chemotherapy after potentially curative resection of stage II colon cancer. J Surg Oncol. 99:65–70. 2009. View Article : Google Scholar

8 

Punt CJ, Buyse M, Köhne CH, et al: Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials. J Natl Cancer Inst. 99:998–1003. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours. 7th edition. Wiley-Blackwell; New York, NY: 2009

10 

Shirouzu K, Isomoto H, Morodomi T and Kakegawa T: Carcinomatous lymphatic permeation. Prognostic significance in patients with rectal carcinoma - a long term prospective study. Cancer. 75:4–10. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Shirouzu K, Isomoto H, Kakegawa T and Morimatsu M: A prospective clinicopathologic study of venous invasion in colorectal cancer. Am J Surg. 162:216–222. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Schrag D, Rifas-Shiman S, Saltz L, Bach PB and Begg CB: Adjuvant chemotherapy use for Medicare beneficiaries with stage II colon cancer. J Clin Oncol. 20:3999–4005. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Gertler R, Rosenberg R, Schuster T and Friess H: Defining a high-risk subgroup with colon cancer stages I and II for possible adjuvant therapy. Eur J Cancer. 45:2992–2999. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Kobayashi H, Mochizuki H, Sugihara K, et al: Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: a multicenter study. Surgery. 141:67–75. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Manfredi S, Bouvier AM, Lepage C, Hatem C, Dancourt V and Faivre J: Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population. Br J Surg. 93:1115–1122. 2006. View Article : Google Scholar : PubMed/NCBI

16 

van Leeuwen BL, Påhlman L, Gunnarsson U, Sjövall A and Martling A: The effect of age and gender on outcome after treatment for colon carcinoma. A population-based study in the Uppsala and Stockholm region. Crit Rev Oncol Hematol. 67:229–236. 2008.PubMed/NCBI

17 

McArdle CS, McMillan DC and Hole DJ: Male gender adversely affects survival following surgery for colorectal cancer. Br J Surg. 90:711–715. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Wichmann MW, Müller C, Hornung HM, Lau-Werner U and Schildberg FW; Colorectal Cancer Study Group. Gender differences in long-term survival of patients with colorectal cancer. Br J Surg. 88:1092–1098. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Oñate-Ocaña LF, Montesdeoca R, López-Graniel CM, et al: Identification of patients with high-risk lymph node-negative colorectal cancer and potential benefit from adjuvant chemotherapy. Jpn J Clin Oncol. 34:323–328. 2004.PubMed/NCBI

20 

Chou CL, Chang SC, Lin TC, et al: Differences in clinicopathological characteristics of colorectal cancer between younger and elderly patients: an analysis of 322 patients from a single institution. Am J Surg. 202:574–582. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Quah HM, Chou JF, Gonen M, et al: Identification of patients with high-risk stage II colon cancer for adjuvant therapy. Dis Colon Rectum. 51:503–507. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Burdy G, Panis Y, Alves A, Nemeth J, Lavergne-Slove A and Valleur P: Identifying patients with T3–T4 node-negative colon cancer at high risk of recurrence. Dis Colon Rectum. 44:1682–1688. 2001.

23 

Lin CC, Lin JK, Chang SC, et al: Is adjuvant chemotherapy beneficial to high risk stage II colon cancer? Analysis in a single institute. Int J Colorectal Dis. 24:665–676. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Mulcahy HE, Toner M, Patchett SE, Daly L and O’Donoghue DP: Identifying stage B colorectal cancer patients at high risk of tumor recurrence and death. Dis Colon Rectum. 40:326–331. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Chin CC, Wang JY, Changchien CR, Huang WS and Tang R: Carcinoma obstruction of the proximal colon cancer and long-term prognosis - obstruction is a predictor of worse outcome in TNM stage II tumor. Int J Colorectal Dis. 25:817–822. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Katoh H, Yamashita K, Wang G, Sato T, Nakamura T and Watanabe M: Prognostic significance of preoperative bowel obstruction in stage III colorectal cancer. Ann Surg Oncol. 18:2432–2441. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Gold P and Freedman SO: Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 121:439–462. 1965. View Article : Google Scholar : PubMed/NCBI

28 

Harrison LE, Guillem JG, Paty P and Cohen AM: Preoperative carcinoembryonic antigen predicts outcomes in node-negative colon cancer patients: a multivariate analysis of 572 patients. J Am Coll Surg. 185:55–59. 1997. View Article : Google Scholar

29 

Wolmark N, Fisher B, Wieand HS, et al: The prognostic significance of preoperative carcinoembryonic antigen levels in colorectal cancer. Results from NSABP (National Surgical Adjuvant Breast and Bowel Project) clinical trials. Ann Surg. 199:375–382. 1984. View Article : Google Scholar

30 

Sener SF, Imperato JP, Chmiel J, Fremgen A and Sylvester J: The use of cancer registry data to study preoperative carcinoembryonic antigen level as an indicator of survival in colorectal cancer. CA Cancer J Clin. 39:50–57. 1989. View Article : Google Scholar : PubMed/NCBI

31 

Wagner HE, Toth CA, Steele GD Jr and Thomas P: Metastatic potential of human colon cancer cell lines: relationship to cellular differentiation and carcinoembryonic antigen production. Clin Exp Metastasis. 10:25–31. 1992. View Article : Google Scholar : PubMed/NCBI

32 

Locker GY, Hamilton S, Harris J, et al; ASCO. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol. 24:5313–5327. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Van Cutsem EJ and Oliveira J; ESMO Guidelines Working Group. Colon cancer: ESMO clinical recommendations for diagnosis, adjuvant treatment and follow-up. Ann Oncol. 19(Suppl 2): ii29–ii30. 2008.

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Copy and paste a formatted citation
Spandidos Publications style
Yamaguchi K, Ogata Y, Akagi Y and Shirouzu K: Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution. Oncol Lett 6: 659-666, 2013.
APA
Yamaguchi, K., Ogata, Y., Akagi, Y., & Shirouzu, K. (2013). Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution. Oncology Letters, 6, 659-666. https://doi.org/10.3892/ol.2013.1433
MLA
Yamaguchi, K., Ogata, Y., Akagi, Y., Shirouzu, K."Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution". Oncology Letters 6.3 (2013): 659-666.
Chicago
Yamaguchi, K., Ogata, Y., Akagi, Y., Shirouzu, K."Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution". Oncology Letters 6, no. 3 (2013): 659-666. https://doi.org/10.3892/ol.2013.1433
Copy and paste a formatted citation
x
Spandidos Publications style
Yamaguchi K, Ogata Y, Akagi Y and Shirouzu K: Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution. Oncol Lett 6: 659-666, 2013.
APA
Yamaguchi, K., Ogata, Y., Akagi, Y., & Shirouzu, K. (2013). Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution. Oncology Letters, 6, 659-666. https://doi.org/10.3892/ol.2013.1433
MLA
Yamaguchi, K., Ogata, Y., Akagi, Y., Shirouzu, K."Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution". Oncology Letters 6.3 (2013): 659-666.
Chicago
Yamaguchi, K., Ogata, Y., Akagi, Y., Shirouzu, K."Identification of high‑risk factors as indicators for adjuvant therapy in stage II colon cancer patients treated at a single institution". Oncology Letters 6, no. 3 (2013): 659-666. https://doi.org/10.3892/ol.2013.1433
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