Primary osteosarcoma of the breast with abundant chondroid matrix and fibroblasts has a good prognosis: A case report and review of the literature

Zhao,Jingjie; Zhang,Xuedong; Liu,Jianwei; Li,Jianhua

doi:10.3892/ol.2013.1446

September 2013 Volume 6 Issue 3

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September 2013 Volume 6 Issue 3

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Case Report

Primary osteosarcoma of the breast with abundant chondroid matrix and fibroblasts has a good prognosis: A case report and review of the literature

Authors:
- Jingjie Zhao
- Xuedong Zhang
- Jianwei Liu
- Jianhua Li
View Affiliations / Copyright

Affiliations: Department of Pathology, Chengde Central Hospital, Chengde, Hebei 067000, P.R. China, Department of Critical Care Medicine, Chengde Central Hospital, Chengde, Hebei 067000, P.R. China, Department of Cardiothoracic Surgery, Chengde Central Hospital, Chengde, Hebei 067000, P.R. China, Department of Oncology, Chengde Central Hospital, Chengde, Hebei 067000, P.R. China
Pages: 745-747
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Published online on: July 5, 2013

https://doi.org/10.3892/ol.2013.1446
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Abstract

The present study describes the case of a 77-year‑old female with a recently self-detected, painless, 7‑cm lump in the left breast, without evidence of metastasis clinically, who underwent mastectomy with dissection of the axillary lymph nodes. The tumor did not invade the chest wall and skin. The tumor was comprised of abundant chondroid matrix and fibrous tissue, with focal osteoid matrix, and was classified as a chondroblastic/fibroblastic variant. The tumor had a reverse zonal pattern. The tumor cells in the central portion were mainly spindle-like and sparse with minimal cytological atypia, while the remaining tumor cells in the periphery were mainly epithelioid, atypical and dense. Neoplastic osteoid woven bone or trabeculae were observed in the central portion of the tumor. No metastasis was identified in the axillary lymph nodes. The patient was alive without evidence of local recurrence or hematogenous spread at the 60-month follow-up.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary osteosarcoma of the breast with abundant chondroid matrix and fibroblasts has a good prognosis: A case report and review of the literature

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Abstract

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