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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September 2013 Volume 6 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo

  • Authors:
    • Nan Wang
    • Lei Zheng
    • Yingzhuan Zhan
    • Yanmin Zhang
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 855-859
    |
    Published online on: July 9, 2013
       https://doi.org/10.3892/ol.2013.1452
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Abstract

Taspine is an attractive target of research due to the anticancer and anti‑angiogenic effects shown by in vitro and in vivo experiments. The present study investigated the role of tas1611, which is a derivative of taspine that has increased activity and solubility, in the regulation of the invasive properties of the SMMC‑7721 liver cell line in vitro and in tumor inhibition in vivo. The proliferation of the SMMC‑7721 cells was examined using the tetrazole blue colorimetric method. Matrigel® invasion chamber assays and zymogram analyses were performed to assess the inhibitory effect of tas1611 on cell invasion. Finally, a solid tumor athymic mouse model was employed to further investigate the anti‑tumor effect of this compound. The results revealed that tas1611 had a marked inhibitory effect on the invasion of the SMMC‑7721 cells and that this effect was associated with the activity and expression levels of matrix metalloproteinase (MMP)‑2 and MMP‑9. Furthermore, tas1611 was able to inhibit tumor growth effectively in a solid tumor SMMC‑7721 athymic mouse model. In conclusion, tas1611 may serve as a promising novel therapeutic candidate for the treatment of metastatic liver cancer.
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View References

1 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Yodkeeree S, Chaiwangyen W, Garbisa S and Limtrakul P: Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr Biochem. 20:87–95. 2009. View Article : Google Scholar

3 

Chaffer CL and Weinberg RA: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Zhang XX, Fu Z, Zhang Z, et al: Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/−9 expression mediated by NF-κB activation. Environ Sci Technol. 46:11319–11326. 2012.PubMed/NCBI

5 

Vargo-Gogola T and Rosen JM: Modelling breast cancer: one size does not fit all. Nat Rev Cancer. 7:659–672. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Hidalgo M and Eckhardt SG: Development of matrix metalloproteinase inhibitors in cancer therapy. J Natl Cancer Inst. 93:178–193. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Chambers AF and Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst. 89:1260–1270. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Y, He L, Meng L, Luo W and Xu X: Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro. Cancer Lett. 262:103–113. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Zhan Y, Wang N, Liu C, Chen Y, Zheng L and He L: A novel taspine derivative, HMQ1611, suppresses adhesion, migration and invasion of ZR-75-30 human breast cancer cells. Breast Cancer. Aug 9–2012.(Epub ahead of print).

10 

Zhang Y, Zheng L, Zhang J, Dai B, Wang N, Chen Y and He L: Anti-tumor activity of taspine by modulating EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo. Planta Med. 77:1774–1781. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Zhang Y, He L, Meng L and Luo W: Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. Vascul Pharmacol. 48:129–137. 2008. View Article : Google Scholar

12 

Zhou Y, Luo W, Zheng L, Li M and Zhang Y: Construction of recombinant FGFR1 containing full-length gene and its potential application. Plasmid. 64:60–67. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Park MK, Jo SH, Lee HJ, et al: Novel suppressive effects of cardamonin on the activity and expression of transglutaminase-2 lead to blocking the migration and invasion of cancer cells. Life Sci. 92:154–160. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Bourd-Boittin K, Fridman R, Fanchon S, Septier D, Goldberg M and Menashi S: Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development. Exp Cell Res. 304:493–505. 2005. View Article : Google Scholar

15 

Zhang YM, Dai BL, Zheng L, et al: A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. Cell Death Dis. 3:e4062012. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Y, Zhang J, Dai B, Wang N and He L: Anti-proliferative and apoptotic effects of the novel taspine derivative tas41 in the Caco-2 cell line. Environ Toxicol Pharmacol. 31:406–415. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Tong D, Czerwenka K, Sedlak J, et al: Association of in vitro invasiveness and gene expression of estrogen receptor, progesterone receptor, pS2 and plasminogen activator inhibitor-1 in human breast cancer cell lines. Breast Cancer Res Treat. 56:91–97. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Yilmaz M, Christofori G and Lehembre F: Distinct mechanisms of tumor invasion and metastasis. Trends Mol Med. 13:535–541. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang N, Zheng L, Zhan Y and Zhang Y: A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo. Oncol Lett 6: 855-859, 2013.
APA
Wang, N., Zheng, L., Zhan, Y., & Zhang, Y. (2013). A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo. Oncology Letters, 6, 855-859. https://doi.org/10.3892/ol.2013.1452
MLA
Wang, N., Zheng, L., Zhan, Y., Zhang, Y."A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo". Oncology Letters 6.3 (2013): 855-859.
Chicago
Wang, N., Zheng, L., Zhan, Y., Zhang, Y."A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo". Oncology Letters 6, no. 3 (2013): 855-859. https://doi.org/10.3892/ol.2013.1452
Copy and paste a formatted citation
x
Spandidos Publications style
Wang N, Zheng L, Zhan Y and Zhang Y: A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo. Oncol Lett 6: 855-859, 2013.
APA
Wang, N., Zheng, L., Zhan, Y., & Zhang, Y. (2013). A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo. Oncology Letters, 6, 855-859. https://doi.org/10.3892/ol.2013.1452
MLA
Wang, N., Zheng, L., Zhan, Y., Zhang, Y."A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo". Oncology Letters 6.3 (2013): 855-859.
Chicago
Wang, N., Zheng, L., Zhan, Y., Zhang, Y."A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo". Oncology Letters 6, no. 3 (2013): 855-859. https://doi.org/10.3892/ol.2013.1452
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