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September 2013 Volume 6 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Differential expression of filamin A and its clinical significance in breast cancer

  • Authors:
    • Hui‑Min Tian
    • Xiu‑Hua Liu
    • Wei Han
    • Ling‑Ling Zhao
    • Bo Yuan
    • Chang‑Ji Yuan
  • View Affiliations / Copyright

    Affiliations: Cancer Center, The First Hospital of Jilin University, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Anesthesia, The First Hospital of Jilin University, Jilin University, Changchun, Jilin 130021, P.R. China, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 681-686
    |
    Published online on: July 9, 2013
       https://doi.org/10.3892/ol.2013.1454
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Abstract

Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathological data, in order to provide insightful ex vivo data. A total of 96 breast cancer and distant normal breast tissues and 20 benign tumor tissue specimens were subjected to immunohistochemistry or reverse transcription polymerase chain reaction (RT‑PCR) analysis of FLNa expression. Clinicopathological data were collected to analyze the association with FLNa expression. The FLNa protein was overexpressed in breast cancer tissues compared with distant normal mammary gland and benign breast tissues. The FLNa protein was expressed in 63.5% of breast cancer, with positive rates of 36, 66.7 and 84.6%, respectively, in stage I, II and III breast cancer patients (P<0.05). Overexpression of the FLNa protein was associated with advanced stage, lymph node metastasis, vascular or neural invasion, menstruation state and other risk stratifications for breast cancer. The overexpression of FLNa in breast cancer was validated by RT‑PCR, indicating transcriptional regulation of FLNa overexpression in breast cancer. FLNa mRNA and protein were overexpressed in breast cancer tissues, which was associated with advanced stage, lymph node metastasis and vascular or neural invasion of breast cancer, suggesting that FLNa contributes to breast cancer development and progression.
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Copy and paste a formatted citation
Spandidos Publications style
Tian HM, Liu XH, Han W, Zhao LL, Yuan B and Yuan CJ: Differential expression of filamin A and its clinical significance in breast cancer. Oncol Lett 6: 681-686, 2013.
APA
Tian, H., Liu, X., Han, W., Zhao, L., Yuan, B., & Yuan, C. (2013). Differential expression of filamin A and its clinical significance in breast cancer. Oncology Letters, 6, 681-686. https://doi.org/10.3892/ol.2013.1454
MLA
Tian, H., Liu, X., Han, W., Zhao, L., Yuan, B., Yuan, C."Differential expression of filamin A and its clinical significance in breast cancer". Oncology Letters 6.3 (2013): 681-686.
Chicago
Tian, H., Liu, X., Han, W., Zhao, L., Yuan, B., Yuan, C."Differential expression of filamin A and its clinical significance in breast cancer". Oncology Letters 6, no. 3 (2013): 681-686. https://doi.org/10.3892/ol.2013.1454
Copy and paste a formatted citation
x
Spandidos Publications style
Tian HM, Liu XH, Han W, Zhao LL, Yuan B and Yuan CJ: Differential expression of filamin A and its clinical significance in breast cancer. Oncol Lett 6: 681-686, 2013.
APA
Tian, H., Liu, X., Han, W., Zhao, L., Yuan, B., & Yuan, C. (2013). Differential expression of filamin A and its clinical significance in breast cancer. Oncology Letters, 6, 681-686. https://doi.org/10.3892/ol.2013.1454
MLA
Tian, H., Liu, X., Han, W., Zhao, L., Yuan, B., Yuan, C."Differential expression of filamin A and its clinical significance in breast cancer". Oncology Letters 6.3 (2013): 681-686.
Chicago
Tian, H., Liu, X., Han, W., Zhao, L., Yuan, B., Yuan, C."Differential expression of filamin A and its clinical significance in breast cancer". Oncology Letters 6, no. 3 (2013): 681-686. https://doi.org/10.3892/ol.2013.1454
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