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Article

Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid

  • Authors:
    • Yoshiko Satomi
    • Hoyoku Nishino
  • View Affiliations / Copyright

    Affiliations: Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513‑8670, Japan, Kyoto Prefectural University of Medicine, Kawaramachi‑Hirokoji, Kamigyo‑ku, Kyoto 602‑8566, Japan
  • Pages: 860-864
    |
    Published online on: July 12, 2013
       https://doi.org/10.3892/ol.2013.1457
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Abstract

Fucoxanthin is a carotenoid that is mainly identified in brown algae and is known to have anticarcinogenic and anti‑tumor activities. Carotenoids have generally been shown to induce the expression and enzyme activity of the cytochrome P450s (CYPs). The present study evaluated the effect of fucoxanthin on the expression and enzymatic activity of the major xenobiotic metabolizing enzymes, CYP1A1, CYP1A2 and CYP3A4. Fucoxanthin markedly induced the expression of cyp1a1 mRNA in HepG2 cells, but inhibited its enzyme activity in the cells and in vitro. Fucoxanthin also inhibited the enzyme activity of CYP1A2 and CYP3A4 in a dose‑dependent manner in vitro. These results suggest that fucoxanthin may serve as a useful agent in cancer prevention with less adverse effects than β‑carotene, including the activation of pro‑carcinogens by CYPs.
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Copy and paste a formatted citation
Spandidos Publications style
Satomi Y and Nishino H: Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid. Oncol Lett 6: 860-864, 2013.
APA
Satomi, Y., & Nishino, H. (2013). Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid. Oncology Letters, 6, 860-864. https://doi.org/10.3892/ol.2013.1457
MLA
Satomi, Y., Nishino, H."Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid". Oncology Letters 6.3 (2013): 860-864.
Chicago
Satomi, Y., Nishino, H."Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid". Oncology Letters 6, no. 3 (2013): 860-864. https://doi.org/10.3892/ol.2013.1457
Copy and paste a formatted citation
x
Spandidos Publications style
Satomi Y and Nishino H: Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid. Oncol Lett 6: 860-864, 2013.
APA
Satomi, Y., & Nishino, H. (2013). Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid. Oncology Letters, 6, 860-864. https://doi.org/10.3892/ol.2013.1457
MLA
Satomi, Y., Nishino, H."Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid". Oncology Letters 6.3 (2013): 860-864.
Chicago
Satomi, Y., Nishino, H."Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid". Oncology Letters 6, no. 3 (2013): 860-864. https://doi.org/10.3892/ol.2013.1457
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