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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October 2013 Volume 6 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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International Journal of Epigenetics

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Case Report

Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports

  • Authors:
    • Kosei Kimura
    • Satoru Tanaka
    • Mitsuhiko Iwamoto
    • Hiroya Fujioka
    • Yuko Takahashi
    • Nayuko Sato
    • Risa Terasawa
    • Tomo Tominaga
    • Ayana Ikari
    • Kazuhisa Uchiyama

  • View Affiliations / Copyright

    Affiliations: Section of Breast and Endocrine Surgery, Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Osaka 569‑8686, Japan
  • Pages: 881-884
    |
    Published online on: July 17, 2013
       https://doi.org/10.3892/ol.2013.1471
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Abstract

Taxanes, including paclitaxel (PTX) and docetaxel (DOC), are poorly soluble in water due to their hydrophobic properties and thus, require solvents. However, use of these solvents has been associated with toxic responses, including a hypersensitivity reaction (HSR). Nanoparticle albumin‑bound paclitaxel (nab‑PTX) is a novel formulation of PTX, which allows reconstitution of the agent with a saline solution instead of solvents and administration without premedication for HSRs. The current study reports the safe administration of nab‑PTX to four breast cancer patients considered clinically to have contraindications to PTX or DOC. Two of the patients had previously experienced HSRs to PTX or DOC and the other two patients had contraindications to steroids as a premedication for HSRs, since one patient suffered from diabetes and the other was a carrier of the hepatitis B virus. All 4 patients were safely administered nab‑PTX. In conclusion, administration of nab‑PTX appears to be effective for patients that have previously experienced HSRs to other taxanes or in those with contraindications to steroids.
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De Laurentiis M, Cancello G, D’Agostino D, et al: Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials. J Clin Oncol. 26:44–53. 2008.PubMed/NCBI

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Piccart-Gebhart MJ, Burzykowski T, Buyse M, et al: Taxanes alone or in combination with anthracyclines as first-line therapy of patients with metastatic breast cancer. J Clin Oncol. 26:1980–1986. 2008. View Article : Google Scholar : PubMed/NCBI

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Gradishar WJ, Tjulandin S, Davidson N, et al: Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol. 23:7794–7803. 2005. View Article : Google Scholar : PubMed/NCBI

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Binder S: Evolution of taxanes in the treatment of metastatic breast cancer. Clin J Oncol Nurs. 17:9–14. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kimura K, Tanaka S, Iwamoto M, Fujioka H, Takahashi Y, Sato N, Terasawa R, Tominaga T, Ikari A, Uchiyama K, Uchiyama K, et al: Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports. Oncol Lett 6: 881-884, 2013.
APA
Kimura, K., Tanaka, S., Iwamoto, M., Fujioka, H., Takahashi, Y., Sato, N. ... Uchiyama, K. (2013). Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports. Oncology Letters, 6, 881-884. https://doi.org/10.3892/ol.2013.1471
MLA
Kimura, K., Tanaka, S., Iwamoto, M., Fujioka, H., Takahashi, Y., Sato, N., Terasawa, R., Tominaga, T., Ikari, A., Uchiyama, K."Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports". Oncology Letters 6.4 (2013): 881-884.
Chicago
Kimura, K., Tanaka, S., Iwamoto, M., Fujioka, H., Takahashi, Y., Sato, N., Terasawa, R., Tominaga, T., Ikari, A., Uchiyama, K."Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports". Oncology Letters 6, no. 4 (2013): 881-884. https://doi.org/10.3892/ol.2013.1471
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura K, Tanaka S, Iwamoto M, Fujioka H, Takahashi Y, Sato N, Terasawa R, Tominaga T, Ikari A, Uchiyama K, Uchiyama K, et al: Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports. Oncol Lett 6: 881-884, 2013.
APA
Kimura, K., Tanaka, S., Iwamoto, M., Fujioka, H., Takahashi, Y., Sato, N. ... Uchiyama, K. (2013). Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports. Oncology Letters, 6, 881-884. https://doi.org/10.3892/ol.2013.1471
MLA
Kimura, K., Tanaka, S., Iwamoto, M., Fujioka, H., Takahashi, Y., Sato, N., Terasawa, R., Tominaga, T., Ikari, A., Uchiyama, K."Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports". Oncology Letters 6.4 (2013): 881-884.
Chicago
Kimura, K., Tanaka, S., Iwamoto, M., Fujioka, H., Takahashi, Y., Sato, N., Terasawa, R., Tominaga, T., Ikari, A., Uchiyama, K."Safety of nanoparticle albumin‑bound paclitaxel administered to breast cancer patients with clinical contraindications to paclitaxel or docetaxel: Four case reports". Oncology Letters 6, no. 4 (2013): 881-884. https://doi.org/10.3892/ol.2013.1471
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