Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells

Tomizawa,Ayako; Kanno,Syu-Ichi; Osanai,Yuu; Yomogida,Shin; Ishikawa,Masaaki

doi:10.3892/ol.2013.1482

October 2013 Volume 6 Issue 4

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October 2013 Volume 6 Issue 4

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Article

Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells

Authors:
- Ayako Tomizawa
- Syu-Ichi Kanno
- Yuu Osanai
- Shin Yomogida
- Masaaki Ishikawa
View Affiliations / Copyright

Affiliations: Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, Sendai, Miyagi 981-8558, Japan
Pages: 875-877
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Published online on: July 23, 2013

https://doi.org/10.3892/ol.2013.1482
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Abstract

Our previous study reported that caffeic acid undecyl ester (CAUE) has a potent cytotoxic effect and induces apoptosis in NALM‑6 cells, but not in normal human lymphocytes. The majority of normal human cells have no detectable telomerase activity, however, activity is commonly detected in cancer cells. Thus, inhibiting telomerase activity and inducing apoptosis may have a selective effect on cancer cells. The aim of the present study was to investigate the inhibitory effects of telomerase activity by CAUE in a NALM‑6 cell culture system. CAUE was shown to preferentially damage DNA synthesis compared with RNA or protein synthesis. In addition, telomerase activity was significantly suppressed and the activity of human telomerase reverse transcriptase (hTERT), a subunit of telomerase, was decreased following treatment with CAUE, each in a concentration‑dependent manner. These results indicated that the cytotoxic effects of CAUE are mediated by the inhibition of DNA synthesis and telomerase activity. The present study is the first to identify the cytotoxic mechanisms of CAUE in leukemia cells.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells

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