Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells

  • Authors:
    • Ayako Tomizawa
    • Syu-Ichi Kanno
    • Yuu Osanai
    • Shin Yomogida
    • Masaaki Ishikawa
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  • Published online on: July 23, 2013     https://doi.org/10.3892/ol.2013.1482
  • Pages: 875-877
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Abstract

Our previous study reported that caffeic acid undecyl ester (CAUE) has a potent cytotoxic effect and induces apoptosis in NALM‑6 cells, but not in normal human lymphocytes. The majority of normal human cells have no detectable telomerase activity, however, activity is commonly detected in cancer cells. Thus, inhibiting telomerase activity and inducing apoptosis may have a selective effect on cancer cells. The aim of the present study was to investigate the inhibitory effects of telomerase activity by CAUE in a NALM‑6 cell culture system. CAUE was shown to preferentially damage DNA synthesis compared with RNA or protein synthesis. In addition, telomerase activity was significantly suppressed and the activity of human telomerase reverse transcriptase (hTERT), a subunit of telomerase, was decreased following treatment with CAUE, each in a concentration‑dependent manner. These results indicated that the cytotoxic effects of CAUE are mediated by the inhibition of DNA synthesis and telomerase activity. The present study is the first to identify the cytotoxic mechanisms of CAUE in leukemia cells.
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October 2013
Volume 6 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tomizawa A, Kanno S, Osanai Y, Yomogida S and Ishikawa M: Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells. Oncol Lett 6: 875-877, 2013
APA
Tomizawa, A., Kanno, S., Osanai, Y., Yomogida, S., & Ishikawa, M. (2013). Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells. Oncology Letters, 6, 875-877. https://doi.org/10.3892/ol.2013.1482
MLA
Tomizawa, A., Kanno, S., Osanai, Y., Yomogida, S., Ishikawa, M."Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells". Oncology Letters 6.4 (2013): 875-877.
Chicago
Tomizawa, A., Kanno, S., Osanai, Y., Yomogida, S., Ishikawa, M."Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B‑cell leukemia cells". Oncology Letters 6, no. 4 (2013): 875-877. https://doi.org/10.3892/ol.2013.1482