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Article

Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis

  • Authors:
    • Yong Zhang
    • Sheng Li
    • Hou‑Qin Xiao
    • Zhao‑Xiong Hu
    • Yan‑Cheng Xu
    • Qi Huang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Nephropathy, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
  • Pages: 1068-1078
    |
    Published online on: July 29, 2013
       https://doi.org/10.3892/ol.2013.1499
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Abstract

Renal cell carcinoma (RCC) accounts for 3% of all cancer‑related mortalities in adults. The risk factors for the development of RCC remain under investigation. Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and is crucial for the development and metastasis of tumors, including RCC. VEGF gene polymorphisms may alter VEGF protein concentrations, affect the process of angiogenesis and may be involved in inter‑individual variation in carcinogenesis. In the present study, a systematic review and meta‑analysis were performed based on published case‑control studies in order to estimate the association between VEGF gene polymorphisms and the susceptibility to RCC. A total of five studies that involved eight polymorphisms and were published between January 2000 and December 2012 were identified from PubMed. The results of this systematic review and meta‑analysis indicate that the VEGF 936C/T, 1612G/A, ‑1154G/A, ‑2549I/D, ‑460T/C and 405G/C gene polymorphisms are not associated with the risk of RCC. There was no polymorphism in 702C/T and RCC and the ‑2578C/A gene polymorphism may be associated with an increased risk of RCC. However, due to the limitations of the present study, further high quality case‑control studies are warranted to confirm these findings.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Li S, Xiao HQ, Hu ZX, Xu YC and Huang Q: Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis. Oncol Lett 6: 1068-1078, 2013.
APA
Zhang, Y., Li, S., Xiao, H., Hu, Z., Xu, Y., & Huang, Q. (2013). Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis. Oncology Letters, 6, 1068-1078. https://doi.org/10.3892/ol.2013.1499
MLA
Zhang, Y., Li, S., Xiao, H., Hu, Z., Xu, Y., Huang, Q."Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 6.4 (2013): 1068-1078.
Chicago
Zhang, Y., Li, S., Xiao, H., Hu, Z., Xu, Y., Huang, Q."Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 6, no. 4 (2013): 1068-1078. https://doi.org/10.3892/ol.2013.1499
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Li S, Xiao HQ, Hu ZX, Xu YC and Huang Q: Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis. Oncol Lett 6: 1068-1078, 2013.
APA
Zhang, Y., Li, S., Xiao, H., Hu, Z., Xu, Y., & Huang, Q. (2013). Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis. Oncology Letters, 6, 1068-1078. https://doi.org/10.3892/ol.2013.1499
MLA
Zhang, Y., Li, S., Xiao, H., Hu, Z., Xu, Y., Huang, Q."Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 6.4 (2013): 1068-1078.
Chicago
Zhang, Y., Li, S., Xiao, H., Hu, Z., Xu, Y., Huang, Q."Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 6, no. 4 (2013): 1068-1078. https://doi.org/10.3892/ol.2013.1499
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