Predicting brain metastases of breast cancer based on serum S100B and serum HER2

  • Authors:
    • Troels Bechmann
    • Jonna Skov Madsen
    • Ivan Brandslund
    • Erik Dalsgaard Lund
    • Tina Ormstrup
    • Erik Hugger Jakobsen
    • Anne Marie Bak Jylling
    • Karina Dahl Steffensen
    • Anders Jakobsen
  • View Affiliations

  • Published online on: August 19, 2013     https://doi.org/10.3892/ol.2013.1536
  • Pages: 1265-1270
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Abstract

Brain metastases are a major cause of morbidity and mortality in breast cancer. The aim of the current study was to evaluate the prediction of brain metastases based on serum S100B and human epidermal growth factor receptor 2 (HER2). A total of 107 breast cancer patients were included in the current study from two prospective cohort studies with either elevated serum HER2 levels >15 ng/ml or brain metastases verified by magnetic resonance imaging (MRI) or computer tomography (CT). Following the exclusion of six patients, the remaining 101 patients were divided into two groups: Group 0 (n=55), patients with normal MRI results; and group 1 (n=46), patients with brain metastases. The levels of serum S100B and HER2 in the two groups were analyzed prior to MRI or CT of the brain, and no significant differences were identified in the serum HER2 (P=0.060) or S100B levels (P=0.623) between the groups. The univariate analysis of prognostic factors for brain metastases showed a significant correlation with systemic disease (P<0.001), axillary lymph node metastases (P=0.001) and serum HER2 >30 ng/ml (P=0.002). Only systemic disease (P<0.001) remained statistically significant in the multivariate analysis. In conclusion, serum levels of S100B and HER2 did not predict the risk of brain metastases. In the multivariate analysis, brain metastases were only found to correlate with systemic disease. However, in the univariate analysis, serum HER2 levels >30 ng/ml were identified to correlate with increased risk of brain metastases, which calls for further investigation.
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November 2013
Volume 6 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Bechmann T, Madsen JS, Brandslund I, Lund ED, Ormstrup T, Jakobsen EH, Jylling AM, Steffensen KD and Jakobsen A: Predicting brain metastases of breast cancer based on serum S100B and serum HER2. Oncol Lett 6: 1265-1270, 2013
APA
Bechmann, T., Madsen, J.S., Brandslund, I., Lund, E.D., Ormstrup, T., Jakobsen, E.H. ... Jakobsen, A. (2013). Predicting brain metastases of breast cancer based on serum S100B and serum HER2. Oncology Letters, 6, 1265-1270. https://doi.org/10.3892/ol.2013.1536
MLA
Bechmann, T., Madsen, J. S., Brandslund, I., Lund, E. D., Ormstrup, T., Jakobsen, E. H., Jylling, A. M., Steffensen, K. D., Jakobsen, A."Predicting brain metastases of breast cancer based on serum S100B and serum HER2". Oncology Letters 6.5 (2013): 1265-1270.
Chicago
Bechmann, T., Madsen, J. S., Brandslund, I., Lund, E. D., Ormstrup, T., Jakobsen, E. H., Jylling, A. M., Steffensen, K. D., Jakobsen, A."Predicting brain metastases of breast cancer based on serum S100B and serum HER2". Oncology Letters 6, no. 5 (2013): 1265-1270. https://doi.org/10.3892/ol.2013.1536