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Article

Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma

  • Authors:
    • Sung Hoon Choi
    • Se Hoon Kim
    • Jun Jeong Choi
    • Chang Moo Kang
    • Ho Kyoung Hwang
    • Woo Jung Lee
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Yonsei University College of Medicine, Seoul 120-752, South Korea, Department of Pathology, Yonsei University College of Medicine, Seoul 120-752, South Korea, Department of Pathology, Yonsei University Wonju College of Medicine, Wonju 220-050, South Korea
  • Pages: 1189-1194
    |
    Published online on: August 21, 2013
       https://doi.org/10.3892/ol.2013.1539
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Abstract

Para‑aortic lymph node (PALN) metastasis is widely regarded as a systemic disease in cancer. Undetected PALN micrometastases during routine hematoxylin and eosin (HE) staining may be a cause of poor prognosis following a potentially curative pancreatectomy for pancreatic cancer. In the present study, paraffin‑embedded PALN tissue blocks from 99 patients who underwent a pancreatectomy were re‑evaluated by immunohistochemical staining using cytokeratin (CK)‑19. Patients with PALN metastasis were summarized according to the clinicopathological data. A total of 484 PALNs (median, 4.9 nodes per patient; range, 1‑19) were evaluated. PALN metastases were revealed in eight patients (8.1%) by routine HE staining of frozen section biopsies and in one patient (1.0%) by HE staining of a permanent section. Only one patient (1.0%) demonstrated micrometastasis by IHC; this patient did not display any adverse pathological characteristics and had a relatively favorable survival period of 41 months. The present study concluded that an additional reassessment for micrometastasis in PALNs using CK‑19 immunohistochemistry (IHC) is not a viable method for determining the survival outcome. A careful examination of a frozen section biopsy is sufficient for attempting curative surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Choi SH, Kim SH, Choi JJ, Kang CM, Hwang HK and Lee WJ: Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma. Oncol Lett 6: 1189-1194, 2013.
APA
Choi, S.H., Kim, S.H., Choi, J.J., Kang, C.M., Hwang, H.K., & Lee, W.J. (2013). Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma. Oncology Letters, 6, 1189-1194. https://doi.org/10.3892/ol.2013.1539
MLA
Choi, S. H., Kim, S. H., Choi, J. J., Kang, C. M., Hwang, H. K., Lee, W. J."Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma". Oncology Letters 6.5 (2013): 1189-1194.
Chicago
Choi, S. H., Kim, S. H., Choi, J. J., Kang, C. M., Hwang, H. K., Lee, W. J."Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma". Oncology Letters 6, no. 5 (2013): 1189-1194. https://doi.org/10.3892/ol.2013.1539
Copy and paste a formatted citation
x
Spandidos Publications style
Choi SH, Kim SH, Choi JJ, Kang CM, Hwang HK and Lee WJ: Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma. Oncol Lett 6: 1189-1194, 2013.
APA
Choi, S.H., Kim, S.H., Choi, J.J., Kang, C.M., Hwang, H.K., & Lee, W.J. (2013). Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma. Oncology Letters, 6, 1189-1194. https://doi.org/10.3892/ol.2013.1539
MLA
Choi, S. H., Kim, S. H., Choi, J. J., Kang, C. M., Hwang, H. K., Lee, W. J."Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma". Oncology Letters 6.5 (2013): 1189-1194.
Chicago
Choi, S. H., Kim, S. H., Choi, J. J., Kang, C. M., Hwang, H. K., Lee, W. J."Clinical necessity of the immunohistochemical reassessment of para‑aortic lymph nodes in resected pancreatic ductal adenocarcinoma". Oncology Letters 6, no. 5 (2013): 1189-1194. https://doi.org/10.3892/ol.2013.1539
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