Reversal of multidrug resistance by the anti‑malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line

  • Authors:
    • Liang Liu
    • Lian Fu Zuo
    • Jian Wen Guo
  • View Affiliations

  • Published online on: August 23, 2013     https://doi.org/10.3892/ol.2013.1545
  • Pages: 1475-1481
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Abstract

The overexpression of ATP‑binding cassette (ABC) transporters confers multidrug resistance (MDR) to tumor cells. ABCG2 is a member of the ABC superfamily. The present study aimed to investigate the correlation between ABCG2 expression and the MDR of esophageal cancer and to estimate the therapeutic benefit of downregulating ABCG2 expression and reversing chemoresistance in esophageal cells using artesunate (Art). The Eca109/ABCG2 cell line was established by transfecting the ABCG2 gene into Eca109 cells. The Eca109/ABCG2 esophageal cancer cells with ABCG2 gene overexpression were resistant to adriamycin (ADM), daunorubicin (DNR) and mitoxantrone (MIT), which indicated that ABCG2 may be associated with drug resistance in esophageal cancer. Art is a noteworthy antimalarial agent, particularly in severe and drug‑resistant cancer cases, as Art is able to reverse drug resistance. In the present study, Art also exerted profound anticancer activity. The mechanism for the reversal of multidrug resistance by Art in esophageal carcinoma was analyzed using cellular experiments, but still remains largely unknown.
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November 2013
Volume 6 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu L, Zuo LF and Guo JW: Reversal of multidrug resistance by the anti‑malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line. Oncol Lett 6: 1475-1481, 2013
APA
Liu, L., Zuo, L.F., & Guo, J.W. (2013). Reversal of multidrug resistance by the anti‑malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line. Oncology Letters, 6, 1475-1481. https://doi.org/10.3892/ol.2013.1545
MLA
Liu, L., Zuo, L. F., Guo, J. W."Reversal of multidrug resistance by the anti‑malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line". Oncology Letters 6.5 (2013): 1475-1481.
Chicago
Liu, L., Zuo, L. F., Guo, J. W."Reversal of multidrug resistance by the anti‑malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line". Oncology Letters 6, no. 5 (2013): 1475-1481. https://doi.org/10.3892/ol.2013.1545