Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling

Fujiwara,Yukio; Takaishi,Kiyomi; Nakao,Junko; Ikeda,Tsuyoshi; Katabuchi,Hidetaka; Takeya,Motohiro; Komohara,Yoshihiro

doi:10.3892/ol.2013.1591

December 2013 Volume 6 Issue 6

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December 2013 Volume 6 Issue 6

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Article

Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling

Authors:
- Yukio Fujiwara
- Kiyomi Takaishi
- Junko Nakao
- Tsuyoshi Ikeda
- Hidetaka Katabuchi
- Motohiro Takeya
- Yoshihiro Komohara
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Affiliations: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860‑8556, Japan, Department of Natural Medicine, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860‑0082, Japan, Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860‑8556
Pages: 1619-1623
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Published online on: September 18, 2013

https://doi.org/10.3892/ol.2013.1591
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Abstract

Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients. The mechanisms of chemoresistance are complex and studies have implicated signal transducer and activator of transcription 3 (STAT3) signaling in the chemoresistance of cancer cells. The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell‑cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage‑induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell‑cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling

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