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Article

Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases

  • Authors:
    • Wei‑Juan Zeng
    • Wen‑Qin Hu
    • Lin‑Wei Wang
    • Shu‑Guang Yan
    • Jian‑Ding Li
    • Hao‑Liang Zhao
    • Chun‑Wei Peng
    • Gui‑Fang Yang
    • Yan Li
  • View Affiliations / Copyright

    Affiliations: Departments of Oncology and Pathology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, Hubei 430071, P.R. China, Department of Surgery, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China, Department of Medical Imaging, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Department of General Surgery, Shanxi University Hospital, Taiyuan, Shanxi 046000, P.R. China
  • Pages: 1693-1700
    |
    Published online on: October 10, 2013
       https://doi.org/10.3892/ol.2013.1615
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Abstract

To study the clinical significance of lymph node ratio (LNR) in gastric cancer (GC), this study analyzed 613 patients with GC who underwent surgical resection. Of 613 patients with GC, 138 patients who had >15 lymph nodes (LNs) resected and radical resection were enrolled into the final study. All major clinicopathological data were entered into a central database. LNR was defined as the ratio of the number of metastatic LNs to the number of removed LNs. In order to determine the best cut‑off points for LNR, the log‑rank test and X‑tile were used. LNR was then substituted for lymph node status (pN) in the 7th American Joint Committee on Cancer tumor‑node‑metastases (TNM) staging system and this was defined as the tumor‑node ratio‑metastases (TRM) staging system. Pearson's correlation coefficient (r) was used to study the correlations among the number of removed LNs, pN and LNR. The Kaplan‑Meier survival curve was used to study the survival status, and the log‑rank test and Cox proportional hazards model were used to identify the independent factors for survival. Receiver operating characteristic curve analysis was used to determine the predictive value of the parameters. By the time of last follow‑up (median follow‑up period, 38.3 months; range, 9.9‑97.7 months), the median overall survival (OS) was 23.9 months [95% confidence interval (CI), 18.8‑29.0 months]. The 1‑, 2‑, 3‑ and 5‑year survival rates were 76.8, 57.2, 50.0 and 46.4%, respectively. The cut‑off points were 0, 0.5 and 0.8 (R0, LNR=0; R1, LNR ≤0.5; R2, 0.5> LNR ≤0.8; and R3, LNR >0.8). Univariate and multivariate analyses revealed that both LNR and pN were independent prognostic factors for GC. LNR could better differentiate OS in patients than LN. In addition, the TRM staging system was better at predicting the clinical outcomes than the TNM staging system, and LNR was better than pN. In conclusion, LNR was a better prognosticator than pN for GC.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Yang L: Incidence and mortality of gastric cancer in China. World J Gastroenterol. 12:17–20. 2006.

4 

Hartgrink HH, Jansen EP, van Grieken NC and van de Velde CJ: Gastric cancer. Lancet. 374:477–490. 2009. View Article : Google Scholar

5 

Wang XN and Liang H: Some problems in the surgical treatment of gastric cancer. Chin J Cancer. 29:369–373. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Viudez-Berral A, Miranda-Murua C, Arias-de-la-Vega F, et al: Current management of gastric cancer. Rev Esp Enferm Dig. 104:134–141. 2012. View Article : Google Scholar

7 

Lee JH, Kim KM, Cheong JH and Noh SH: Current management and future strategies of gastric cancer. Yonsei Med J. 53:248–257. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Wu HL, Tian Q, Peng CW, Liu SP and Li Y: Multivariate survival and outcome analysis of 154 patients with gastric cancer at a single Chinese institution. Asian Pac J Cancer Prev. 12:3341–3345. 2011.PubMed/NCBI

9 

Landry CS, Brock G, Scoggins CR, McMasters KM and Martin RN II: A proposed staging system for gastric carcinoid tumors based on an analysis of 1,543 patients. Ann Surg Oncol. 16:51–60. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Cammerer G, Formentini A, Karletshofer M, Henne-Bruns D and Kornmann M: Evaluation of important prognostic clinical and pathological factors in gastric cancer. Anticancer Res. 32:1839–1842. 2012.PubMed/NCBI

11 

Washington K: 7th edition of the AJCC cancer staging manual: stomach. Ann Surg Oncol. 17:3077–3079. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Sun Z, Wang ZN, Zhu Z, et al: Evaluation of the seventh edition of American Joint Committee on Cancer TNM staging system for gastric cancer: results from a Chinese monoinstitutional study. Ann Surg Oncol. 19:1918–1927. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Chae S, Lee A and Lee JH: The effectiveness of the new (7th) UICC N classification in the prognosis evaluation of gastric cancer patients: a comparative study between the 5th/6th and 7th UICC N classification. Gastric Cancer. 14:166–171. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Ahn HS, Lee HJ, Hahn S, et al: Evaluation of the seventh American Joint Committee on Cancer/International Union Against Cancer Classification of gastric adenocarcinoma in comparison with the sixth classification. Cancer. 116:5592–5598. 2010. View Article : Google Scholar

15 

Wang W, Sun XW, Li CF, et al: Comparison of the 6th and 7th editions of the UICC TNM staging system for gastric cancer: results of a Chinese single-institution study of 1,503 patients. Ann Surg Oncol. 18:1060–1067. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Kim SS, Choi BY, Seo SI, et al: The comparison between 6th and 7th International Union Against Cancer/American Joint Committee on Cancer Classification for Survival Prognosis of Gastric Cancer. Korean J Gastroenterol. 58:258–263. 2011.(In Korean).

17 

Wang W, Xu DZ, Li YF, et al: Tumor-ratio-metastasis staging system as an alternative to the 7th edition UICC TNM system in gastric cancer after D2 resection - results of a single-institution study of 1343 Chinese patients. Ann Oncol. 22:2049–2056. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Wang J, Dang P, Raut CP, et al: Comparison of a lymph node ratio-based staging system with the 7th AJCC system for gastric cancer: analysis of 18,043 patients from the SEER database. Ann Surg. 255:478–485. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Lee SR, Kim HO, Son BH, Shin JH and Yoo CH: Prognostic significance of the metastatic lymph node ratio in patients with gastric cancer. World J Surg. 36:1096–1101. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Liu X, Cai H, Shi Y and Wang Y: Prognostic factors in patients with node-negative gastric cancer: a single center experience from China. J Gastrointest Surg. 16:1123–1127. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Diaz de Liaño A, Yarnoz C, Aguilar R, Artieda C and Ortiz H: Rationale for gastrectomy with D2 lymphadenectomy in the treatment of gastric cancer. Gastric Cancer. 11:96–102. 2008.PubMed/NCBI

22 

D’Annibale A, Pende V, Pernazza G, et al: Full robotic gastrectomy with extended (D2) lymphadenectomy for gastric cancer: surgical technique and preliminary results. J Surg Res. 166:113–120. 2011.PubMed/NCBI

23 

Kim CY and Yang DH: Adjustment of N stages of gastric cancer by the ratio between the metastatic and examined lymph nodes. Ann Surg Oncol. 16:1868–1874. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Asoglu O, Karanlik H, Parlak M, et al: Metastatic lymph node ratio is an independent prognostic factor in gastric cancer. Hepatogastroenterology. 56:908–913. 2009.PubMed/NCBI

25 

Xu DZ, Geng QR, Long ZJ, et al: Positive lymph node ratio is an independent prognostic factor in gastric cancer after d2 resection regardless of the examined number of lymph nodes. Ann Surg Oncol. 16:319–326. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Lee SY, Hwang I, Park YS, Gardner J and Ro JY: Metastatic lymph node ratio in advanced gastric carcinoma: A better prognostic factor than number of metastatic lymph nodes? Int J Oncol. 36:1461–1467. 2010.PubMed/NCBI

27 

Huang CM, Lin JX, Zheng CH, et al: Prognostic impact of metastatic lymph node ratio on gastric cancer after curative distal gastrectomy. World J Gastroenterol. 16:2055–2060. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Feng J, Wu YF, Xu HM, Wang SB and Chen JQ: Prognostic significance of the metastatic lymph node ratio in T3 gastric cancer patients undergoing total gastrectomy. Asian Pac J Cancer Prev. 12:3289–3292. 2011.PubMed/NCBI

29 

Lemmens V, Dassen AE, van der Wurff A, Coebergh J and Bosscha K: Lymph node examination among patients with gastric cancer: variation between departments of pathology and prognostic impact of lymph node ratio. Eur J Surg Oncol. 37:488–496. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Qiu MZ, Qiu HJ, Wang ZQ, et al: The tumor-log odds of positive lymph nodes-metastasis staging system, a promising new staging system for gastric cancer after D2 resection in China. PLoS One. 7:e317362012. View Article : Google Scholar : PubMed/NCBI

31 

Peng CW, Wang LW, zeng WJ, Yang XJ and Li Y: Evaluation of the staging system for gastric cancer. J Surg Oncol. 108:93–105. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zeng WJ, Hu WQ, Wang LW, Yan SG, Li JD, Zhao HL, Peng CW, Yang GF and Li Y: Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases. Oncol Lett 6: 1693-1700, 2013.
APA
Zeng, W., Hu, W., Wang, L., Yan, S., Li, J., Zhao, H. ... Li, Y. (2013). Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases. Oncology Letters, 6, 1693-1700. https://doi.org/10.3892/ol.2013.1615
MLA
Zeng, W., Hu, W., Wang, L., Yan, S., Li, J., Zhao, H., Peng, C., Yang, G., Li, Y."Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases". Oncology Letters 6.6 (2013): 1693-1700.
Chicago
Zeng, W., Hu, W., Wang, L., Yan, S., Li, J., Zhao, H., Peng, C., Yang, G., Li, Y."Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases". Oncology Letters 6, no. 6 (2013): 1693-1700. https://doi.org/10.3892/ol.2013.1615
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng WJ, Hu WQ, Wang LW, Yan SG, Li JD, Zhao HL, Peng CW, Yang GF and Li Y: Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases. Oncol Lett 6: 1693-1700, 2013.
APA
Zeng, W., Hu, W., Wang, L., Yan, S., Li, J., Zhao, H. ... Li, Y. (2013). Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases. Oncology Letters, 6, 1693-1700. https://doi.org/10.3892/ol.2013.1615
MLA
Zeng, W., Hu, W., Wang, L., Yan, S., Li, J., Zhao, H., Peng, C., Yang, G., Li, Y."Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases". Oncology Letters 6.6 (2013): 1693-1700.
Chicago
Zeng, W., Hu, W., Wang, L., Yan, S., Li, J., Zhao, H., Peng, C., Yang, G., Li, Y."Lymph node ratio is a better prognosticator than lymph node status for gastric cancer: A retrospective study of 138 cases". Oncology Letters 6, no. 6 (2013): 1693-1700. https://doi.org/10.3892/ol.2013.1615
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