Tumor immunotherapy based on tumor‑derived heat shock proteins (Review)

  • Authors:
    • Yunfei Zhang
    • Lianhe Zheng
  • View Affiliations

  • Published online on: October 10, 2013     https://doi.org/10.3892/ol.2013.1616
  • Pages: 1543-1549
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Abstract

Heat shock proteins (HSPs), the most important type of molecular chaperone, are expressed in all eukaryotic cells and have multiple functions, including the folding and unfolding of other proteins and peptides, the transport of proteins and peptides and the support of antigen presentation processes. Due to these important properties, the use of HSPs has been explored as a promising tumor immunotherapy strategy. It has been previously demonstrated that HSP peptide complex (HSP.PC) derived from tumors is the immunogenic entity that elicits powerful antitumor immune responses. Previous animal studies and phase III clinical trials have demonstrated the efficacy, safety and feasibility of HSP‑based tumor vaccines. However, the limitations are also apparent and specific alternatives have been developed. The present review focused on the history of HSP‑based immunotherapy, the mechanism of its immunogenicity and the previous efforts to promote the efficacy. The current review may be useful for antitumor studies based on the tumor‑derived HSPs.
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December 2013
Volume 6 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Y and Zhang Y: Tumor immunotherapy based on tumor‑derived heat shock proteins (Review). Oncol Lett 6: 1543-1549, 2013
APA
Zhang, Y., & Zhang, Y. (2013). Tumor immunotherapy based on tumor‑derived heat shock proteins (Review). Oncology Letters, 6, 1543-1549. https://doi.org/10.3892/ol.2013.1616
MLA
Zhang, Y., Zheng, L."Tumor immunotherapy based on tumor‑derived heat shock proteins (Review)". Oncology Letters 6.6 (2013): 1543-1549.
Chicago
Zhang, Y., Zheng, L."Tumor immunotherapy based on tumor‑derived heat shock proteins (Review)". Oncology Letters 6, no. 6 (2013): 1543-1549. https://doi.org/10.3892/ol.2013.1616