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December 2013 Volume 6 Issue 6

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome

  • Authors:
    • Thomas Melchardt
    • Lukas Weiss
    • Lisa Pleyer
    • Susanne Steinkirchner
    • Jutta Auberger
    • Georg Hopfinger
    • Richard Greil
    • Alexander Egle

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Disease and Rheumatology, Oncological Center, Laboratory for Immunological and Molecular Cancer Research, Paracelsus Medical University of Salzburg, Salzburg A‑5020, Austria
  • Pages: 1756-1758
    |
    Published online on: October 15, 2013
       https://doi.org/10.3892/ol.2013.1629
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Abstract

5‑Azacytidine (5‑AZA) was the first drug to be approved for the treatment of high‑risk myelodysplastic syndrome (MDS). The adverse event profile of this drug appears favorable compared with the conventional intensive chemotherapy that is used for MDS or acute myeloid leukemia. However, uncommon adverse events may have remained undetected in the limited number of patients that have been treated to date. The present study describes three cases/66.8 person‑years (4,491 cases/100,000 person‑years) of severe ischemic colitis in a single center cohort of 95 patients who were consecutively treated using subcutaneous 5‑AZA. The results demonstrated a much higher incidence of colitis compared with the rates in the general population or in patients of greater ages and co‑morbidities. The present study investigated whether the combination of anemia and constipation due to the co‑medication of 5‑HT3 receptor antagonists may explain the three cases of ischemic colitis.
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Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, Schoch R, Gattermann N, Sanz G, List A, Gore SD, Seymour JF, Bennett JM, Byrd J, Backstrom J, Zimmerman L, McKenzie D, Beach C and Silverman LR; International Vidaza High-Risk MDS Survival Study Group. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 10:223–232. 2009. View Article : Google Scholar : PubMed/NCBI

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4 

Pleyer L, Stauder R, Burgstaller S, Schreder M, Tinchon C, Pfeilstocker M, Steinkirchner S, Melchardt T, Mitrovic M, Girschikofsky M, Lang A, Krippl P, Sliwa T, Egle A, Linkesch W, Voskova D, Angermann H and Greil R: Activity of azacitidine in 26 unselected, consecutive CMML patients included in the Austrian Azacitidine Registry (AAR) of the AGMT-study group. Blood. 118:7472011.

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Copy and paste a formatted citation
Spandidos Publications style
Melchardt T, Weiss L, Pleyer L, Steinkirchner S, Auberger J, Hopfinger G, Greil R and Egle A: Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome. Oncol Lett 6: 1756-1758, 2013.
APA
Melchardt, T., Weiss, L., Pleyer, L., Steinkirchner, S., Auberger, J., Hopfinger, G. ... Egle, A. (2013). Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome. Oncology Letters, 6, 1756-1758. https://doi.org/10.3892/ol.2013.1629
MLA
Melchardt, T., Weiss, L., Pleyer, L., Steinkirchner, S., Auberger, J., Hopfinger, G., Greil, R., Egle, A."Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome". Oncology Letters 6.6 (2013): 1756-1758.
Chicago
Melchardt, T., Weiss, L., Pleyer, L., Steinkirchner, S., Auberger, J., Hopfinger, G., Greil, R., Egle, A."Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome". Oncology Letters 6, no. 6 (2013): 1756-1758. https://doi.org/10.3892/ol.2013.1629
Copy and paste a formatted citation
x
Spandidos Publications style
Melchardt T, Weiss L, Pleyer L, Steinkirchner S, Auberger J, Hopfinger G, Greil R and Egle A: Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome. Oncol Lett 6: 1756-1758, 2013.
APA
Melchardt, T., Weiss, L., Pleyer, L., Steinkirchner, S., Auberger, J., Hopfinger, G. ... Egle, A. (2013). Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome. Oncology Letters, 6, 1756-1758. https://doi.org/10.3892/ol.2013.1629
MLA
Melchardt, T., Weiss, L., Pleyer, L., Steinkirchner, S., Auberger, J., Hopfinger, G., Greil, R., Egle, A."Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome". Oncology Letters 6.6 (2013): 1756-1758.
Chicago
Melchardt, T., Weiss, L., Pleyer, L., Steinkirchner, S., Auberger, J., Hopfinger, G., Greil, R., Egle, A."Complications of 5‑azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome". Oncology Letters 6, no. 6 (2013): 1756-1758. https://doi.org/10.3892/ol.2013.1629
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