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Review

N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)

  • Authors:
    • Yan Song
    • Lili Cao
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 1539-1542
    |
    Published online on: October 18, 2013
       https://doi.org/10.3892/ol.2013.1636
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Abstract

N‑myc downstream‑regulated gene 1 (NDRG1) has been reported to be a multifunctional protein associated with carcinogenesis and tumor progression. However, the cellular function of NDRG1 remains elusive in human hepatocellular carcinoma (HCC). No NDRG1 expression is observed in normal liver tissue. Overexpression of NDRG1 has been observed in human HCC, particularly with aggressive invasion, metastasis, poor differentiation and short patient survival. In addition, recent studies have shown that NDRG1 exhibits an inhibitory effect on HCC growth in vitro and in vivo, which contrasts with previous reports indicating that NDRG1 promotes the proliferation and invasion of HCC cell lines. Further studies have shown that the localization of NDRG1 is variable, translocating to the nucleus or membrane according to the cell state, which may relate to the diverse function of NDRG1. The present study reviews our current knowledge with regard to the functions of NDRG1 in HCC and other types of human cancer.
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1 

Bruix J and Llovet JM: Major achievements in hepatocellular carcinoma. Lancet. 373:614–616. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Iiizumi M, Liu W, Pai SK, Furuta E and Watabe K: Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy. Biochim Biophys Acta. 1786:87–104. 2008.PubMed/NCBI

3 

Forner A, Reig ME, de Lope CR and Bruix J: Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis. 30:61–74. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Llovet JM, Fuster J and Bruix J; Barcelona-Clínic Liver Cancer Group. The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma. Liver Transpl. 10(2 Suppl 1): S115–S120. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Yeh CN, Chen MF, Lee WC and Jeng LB: Prognostic factors of hepatic resection for hepatocellular carcinoma with cirrhosis: univariate and multivariate analysis. J Surg Oncol. 81:195–202. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Hanazaki K, Kajikawa S, Koide N, Adachi W and Amano J: Prognostic factors after hepatic resection for hepatocellular carcinoma with hepatitis C viral infection: univariate and multivariate analysis. Am J Gastroenterol. 96:1243–1250. 2001. View Article : Google Scholar

7 

Tsai T, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hsia CY and Wu CW: Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma. Surgery. 127:603–608. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Imamura H, Matsuyama Y, Tanaka E, et al: Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol. 38:200–207. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Zhou D, Salnikow K and Costa M: Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res. 58:2182–2189. 1998.PubMed/NCBI

10 

Kokame K, Kato H and Miyata T: Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J Biol Chem. 271:29659–29665. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Akiba J, Ogasawara S, Kawahara A, et al: N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma. Oncol Rep. 20:1329–1335. 2008.PubMed/NCBI

12 

Chua MS, Sun H, Cheung ST, et al: Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod Pathol. 20:76–83. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Cheng J, Xie HY, Xu X, et al: NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma. Cancer Lett. 310:35–45. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Guan RJ, Ford HL, Fu Y, Li Y, Shaw LM and Pardee AB: Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res. 60:749–755. 2000.PubMed/NCBI

15 

Strzelczyk B, Szulc A, Rzepko R, et al: Identification of high-risk stage II colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion. Ann Surg Oncol. 16:1287–1294. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Maruyama Y, Ono M, Kawahara A, et al: Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis. Cancer Res. 66:6233–6242. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Song Y, Oda Y, Hori M, et al: N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin. Hum Pathol. 41:214–222. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Sibold S, Roh V, Keogh A, et al: Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS Lett. 581:989–994. 2007. View Article : Google Scholar

19 

Budhu A, Forgues M, Ye Q-H, et al: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell. 10:99–111. 2006. View Article : Google Scholar

20 

Kurdistani SK, Arizti P, Reimer CL, Sugrue MM, Aaronson SA and Lee SW: Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 58:4439–4444. 1998.PubMed/NCBI

21 

Akiba J, Murakami Y, Noda M, et al: N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phase. Cancer Lett. 310:25–34. 2011. View Article : Google Scholar : PubMed/NCBI

22 

McCaig C, Potter L, Abramczyk O and Murray JT: Phosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle. Biochem Biophys Res Commun. 411:227–234. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Taketomi Y, Sugiki T, Saito T, et al: Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells. Biochem Biophys Res Commun. 306:339–346. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Piquemal D, Joulia D, Balaguer P, Basset A, Marti J and Commes T: Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells. Biochim Biophys Acta. 1450:364–373. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Angst E, Sibold S, Tiffon C, et al: Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer. Br J Cancer. 95:307–313. 2006. View Article : Google Scholar

26 

Mao XY, Fan CF, Wei J, et al: Increased N-myc downstream-regulated gene 1 expression is associated with breast atypia-to-carcinoma progression. Tumour Biol. 32:1271–1276. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Fotovati A, Abu-Ali S, Kage M, Shirouzu K, Yamana H and Kuwano M: N-myc downstream-regulated gene 1 (NDRG1) a differentiation marker of human breast cancer. Pathol Oncol Res. 17:525–533. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Yan X, Chua MS, Sun H and So S: N-Myc down-regulated gene 1 mediates proliferation, invasion, and apoptosis of hepatocellular carcinoma cells. Cancer Lett. 262:133–142. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Ureshino H, Murakami Y, Watari K, et al: N-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition. PLoS One. 7:e413122012. View Article : Google Scholar

30 

Chen Z, Zhang D, Yue F, Zheng M, Kovacevic Z and Richardson DR: The iron chelators Dp44mT and DFO inhibit TGF-beta-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). J Biol Chem. 287:17016–17028. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Tu LC, Yan X, Hood L and Lin B: Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. Mol Cell Proteomics. 6:575–588. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Kachhap SK, Faith D, Qian DZ, et al: The N-Myc down regulated Gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin. PLoS One. 2:e8442007. View Article : Google Scholar : PubMed/NCBI

33 

Klaus A and Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 8:387–398. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Stein S, Thomas EK, Herzog B, et al: NDRG1 is necessary for p53-dependent apoptosis. J Biol Chem. 279:48930–48940. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Jung EU, Yoon JH, Lee YJ, et al: Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells. Cancer Lett. 298:9–15. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Zhang AH, Rao JN, Zou T, et al: p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion. Am J Physiol Cell Physiol. 293:C379–C389. 2007. View Article : Google Scholar

37 

Kovacevic Z, Sivagurunathan S, Mangs H, Chikhani S, Zhang D and Richardson DR: The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms. Carcinogenesis. 32:732–740. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Kim KR, Moon HE and Kim KW: Hypoxia-induced angiogenesis in human hepatocellular carcinoma. J Mol Med (Berl). 80:703–714. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Huang GW, Yang LY and Lu WQ: Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival. World J Gastroenterol. 11:1705–1708. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Bristow RG and Hill RP: Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer. 8:180–192. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Corn PG and El-Deiry WS: Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage. Cancer Biol Ther. 6:1858–1866. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Prabhakar NR: Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol. 90:1986–1994. 2001.PubMed/NCBI

43 

Bandyopadhyay S, Pai SK, Gross SC, et al: The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 63:1731–1736. 2003.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song Y and Cao L: N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review). Oncol Lett 6: 1539-1542, 2013.
APA
Song, Y., & Cao, L. (2013). N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review). Oncology Letters, 6, 1539-1542. https://doi.org/10.3892/ol.2013.1636
MLA
Song, Y., Cao, L."N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)". Oncology Letters 6.6 (2013): 1539-1542.
Chicago
Song, Y., Cao, L."N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)". Oncology Letters 6, no. 6 (2013): 1539-1542. https://doi.org/10.3892/ol.2013.1636
Copy and paste a formatted citation
x
Spandidos Publications style
Song Y and Cao L: N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review). Oncol Lett 6: 1539-1542, 2013.
APA
Song, Y., & Cao, L. (2013). N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review). Oncology Letters, 6, 1539-1542. https://doi.org/10.3892/ol.2013.1636
MLA
Song, Y., Cao, L."N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)". Oncology Letters 6.6 (2013): 1539-1542.
Chicago
Song, Y., Cao, L."N‑myc downstream‑regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)". Oncology Letters 6, no. 6 (2013): 1539-1542. https://doi.org/10.3892/ol.2013.1636
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