Endoplasmic reticulum stress in diethylnitrosamine‑induced rat liver cancer

Xiao,Bin; Cui,Li‑Min; Ma,Dong‑Jie; Liu,Shuang‑Ping; Zhang,Xue‑Wu

doi:10.3892/ol.2013.1651

2014-January Volume 7 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

2014-January Volume 7 Issue 1

Full Size Image

Article

Endoplasmic reticulum stress in diethylnitrosamine‑induced rat liver cancer

Authors:
- Bin Xiao
- Li‑Min Cui
- Dong‑Jie Ma
- Shuang‑Ping Liu
- Xue‑Wu Zhang
View Affiliations / Copyright

Affiliations: College of Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China
Pages: 23-27
|
Published online on: October 29, 2013

https://doi.org/10.3892/ol.2013.1651
Expand metrics +

Abstract

To analyze the significance of endoplasmic reticulum stress (ERS) in the development of diethylnitrosamine (DEN)‑induced liver cancer in rats, critical regulatory factors in ERS signaling pathways were investigated in the present study. The results showed that the expression of ERS‑related proteins gradually increased in the early and mid‑term stages of carcinogenesis, while in the later stages, the expression of these proteins did not change significantly after reaching a peak. ERS is involved in DEN‑induced rat liver injury, the proliferation of liver cells and the occurrence and development of liver cirrhosis. However, ERS did not affect hepatoma cell growth following the formation of rat liver cancer in the current study.

View Figures

View References

1	Ciccaglione AR, Marcantonio C, Tritarelli E, Equestre M, Vendittelli F, Costantino A, Geraci A and Rapicetta M: Activation of the ER stress gene gadd153 by hepatitis C virus sensitizes cells to oxidant injury. Virus Res. 126:128–138. 2007. View Article : Google Scholar : PubMed/NCBI
2	Asselah T, Bièche I, Mansouri A, Laurendeau I, Cazals-Hatem D, Feldmann G, Bedossa P, Paradis V, Martinot-Peignoux M, Lebrec D, et al: In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C. J Pathol. 221:264–274. 2010. View Article : Google Scholar : PubMed/NCBI
3	Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS and Klein S: Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes. 58:693–700. 2009. View Article : Google Scholar
4	Ji C and Kaplowitz N: Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 124:1488–1499. 2003. View Article : Google Scholar
5	Nagy G, Szarka A, Lotz G, Dóczi J, Wunderlich L, Kiss A, Jemnitz K, Veres Z, Bánhegyi G, Schaff Z, et al: BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury. Toxicol Appl Pharmacol. 243:96–103. 2010. View Article : Google Scholar : PubMed/NCBI
6	Fu Y and Lee AS: Glucose regulated proteins in cancer progression, drug resistance and immunotherapy. Cancer Biol Ther. 5:741–744. 2006. View Article : Google Scholar : PubMed/NCBI
7	Zhang ZM, Wang G, Chen C, Xu W, Li Q, Hu Q, Wang D and Li ZP: Pathologic and morphologic study on modified DEN-induced hepatocarcinoma model in rats. Di San Jun Yi Da Xue. 12:1164–1167. 2007.
8	Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum coordination of gene transcriptional and transcriptional controls. Genes Dev. 13:1211–1233. 1999. View Article : Google Scholar
9	Mori K: Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 101:451–454. 2000. View Article : Google Scholar : PubMed/NCBI
10	Matsuzaki S, Hiratsuka T, Kuwahara R, Katayama T and Tohyama M: Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress. Neurochem Int. 56:352–356. 2010.PubMed/NCBI
11	Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM and Walter P: IRE1 signaling affects cell fate during the unfolded protein response. Science. 318:944–949. 2007. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Endoplasmic reticulum stress in diethylnitrosamine‑induced rat liver cancer

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Related Articles