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Article

Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer

  • Authors:
    • Yasutomo Sekido
    • Masaya Mukai
    • Masashi Yamazaki
    • Takayuki Tajima
    • Souichirou Yamamoto
    • Sayuri Hasegawa
    • Kyoko Kishima
    • Takuma Tajiri
    • Naoya Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan, Department of Surgery, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan, Department of Pathology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan
  • Pages: 53-58
    |
    Published online on: November 6, 2013
       https://doi.org/10.3892/ol.2013.1660
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Abstract

In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-year overall survival rate (5Y-OS) of the ONC(+) and ONC(-) groups. The 5Y-RFS was 71.4% in the ONC(-) group and 47.5% in the ONC(+) group (P=0.003). The 5Y-OS was 68.8 and 48.4%, respectively (P=0.008). ONCs were found in 34.8% of stage II patients and were also detected in 66.7% of stage III patients. For distinguishing between the recurrence and non-recurrence groups, the sensitivity of ONC(+) was 64.5% (40/62; P=0.003), the positive predictive value (PPV) was 49.4% (40/81), the specificity was 59.8% (61/102) and the negative predictive value (NPV) was 73.5% (61/83). This high sensitivity indicates that ONC positivity may be a significant indicator for high-risk patients in the early postoperative period, and a lack of ONCs may be a useful indicator for identifying low-risk patients, as patients without ONCs had a high NPV.
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Copy and paste a formatted citation
Spandidos Publications style
Sekido Y, Mukai M, Yamazaki M, Tajima T, Yamamoto S, Hasegawa S, Kishima K, Tajiri T and Nakamura N: Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer. Oncol Lett 7: 53-58, 2014.
APA
Sekido, Y., Mukai, M., Yamazaki, M., Tajima, T., Yamamoto, S., Hasegawa, S. ... Nakamura, N. (2014). Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer. Oncology Letters, 7, 53-58. https://doi.org/10.3892/ol.2013.1660
MLA
Sekido, Y., Mukai, M., Yamazaki, M., Tajima, T., Yamamoto, S., Hasegawa, S., Kishima, K., Tajiri, T., Nakamura, N."Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer". Oncology Letters 7.1 (2014): 53-58.
Chicago
Sekido, Y., Mukai, M., Yamazaki, M., Tajima, T., Yamamoto, S., Hasegawa, S., Kishima, K., Tajiri, T., Nakamura, N."Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer". Oncology Letters 7, no. 1 (2014): 53-58. https://doi.org/10.3892/ol.2013.1660
Copy and paste a formatted citation
x
Spandidos Publications style
Sekido Y, Mukai M, Yamazaki M, Tajima T, Yamamoto S, Hasegawa S, Kishima K, Tajiri T and Nakamura N: Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer. Oncol Lett 7: 53-58, 2014.
APA
Sekido, Y., Mukai, M., Yamazaki, M., Tajima, T., Yamamoto, S., Hasegawa, S. ... Nakamura, N. (2014). Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer. Oncology Letters, 7, 53-58. https://doi.org/10.3892/ol.2013.1660
MLA
Sekido, Y., Mukai, M., Yamazaki, M., Tajima, T., Yamamoto, S., Hasegawa, S., Kishima, K., Tajiri, T., Nakamura, N."Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer". Oncology Letters 7.1 (2014): 53-58.
Chicago
Sekido, Y., Mukai, M., Yamazaki, M., Tajima, T., Yamamoto, S., Hasegawa, S., Kishima, K., Tajiri, T., Nakamura, N."Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer". Oncology Letters 7, no. 1 (2014): 53-58. https://doi.org/10.3892/ol.2013.1660
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