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2014-January Volume 7 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma

  • Authors:
    • Ankang Hu
    • Xiaoqian Dong
    • Xiqian Liu
    • Ping Zhang
    • Yonghong  Zhang
    • Ning Su
    • Qianming Chen
    • Yun Feng
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 115-120
    |
    Published online on: November 7, 2013
       https://doi.org/10.3892/ol.2013.1665
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Abstract

Natural killer (NK) cells and cytolytic T lymphocytes (CTLs) serve as effectors in the antitumor response. High mobility group nucleosomal binding domain 2 (HMGN2) is a candidate effector molecule involved in CTL and NK cell function. In the current study, recombinant human HMGN2 was isolated and purified from transformed Escherichia coli. Tca8113 cells, an oral squamous cell carcinoma line, were treated with a variety of HMGN2 protein concentrations and cell growth was analyzed. HMGN2 significantly inhibited the growth of Tca8113 cells and was predicted to arrest cells in the S phase. Moreover, HMGN2 treatment increased the apoptosis rate of Tca8113 cells. Western blotting indicated the upregulation of p53 and Bax proteins, whereas Bcl‑2 was significantly downregulated. In addition, caspase‑3 was found to be activated. Furthermore, the HMGN2 protein may suppress the growth of Tca8113 cells in vivo. The results of the current study indicated that the HMGN2 protein may inhibit the growth of oral squamous cell carcinoma and HMGN2 may represent an antitumor effector molecule of CTL or NK cells.
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Copy and paste a formatted citation
Spandidos Publications style
Hu A, Dong X, Liu X, Zhang P, Zhang Y, Su N, Chen Q and Feng Y: Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma. Oncol Lett 7: 115-120, 2014.
APA
Hu, A., Dong, X., Liu, X., Zhang, P., Zhang, Y., Su, N. ... Feng, Y. (2014). Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma. Oncology Letters, 7, 115-120. https://doi.org/10.3892/ol.2013.1665
MLA
Hu, A., Dong, X., Liu, X., Zhang, P., Zhang, Y., Su, N., Chen, Q., Feng, Y."Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma". Oncology Letters 7.1 (2014): 115-120.
Chicago
Hu, A., Dong, X., Liu, X., Zhang, P., Zhang, Y., Su, N., Chen, Q., Feng, Y."Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma". Oncology Letters 7, no. 1 (2014): 115-120. https://doi.org/10.3892/ol.2013.1665
Copy and paste a formatted citation
x
Spandidos Publications style
Hu A, Dong X, Liu X, Zhang P, Zhang Y, Su N, Chen Q and Feng Y: Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma. Oncol Lett 7: 115-120, 2014.
APA
Hu, A., Dong, X., Liu, X., Zhang, P., Zhang, Y., Su, N. ... Feng, Y. (2014). Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma. Oncology Letters, 7, 115-120. https://doi.org/10.3892/ol.2013.1665
MLA
Hu, A., Dong, X., Liu, X., Zhang, P., Zhang, Y., Su, N., Chen, Q., Feng, Y."Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma". Oncology Letters 7.1 (2014): 115-120.
Chicago
Hu, A., Dong, X., Liu, X., Zhang, P., Zhang, Y., Su, N., Chen, Q., Feng, Y."Nucleosome‑binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma". Oncology Letters 7, no. 1 (2014): 115-120. https://doi.org/10.3892/ol.2013.1665
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