Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

Ishida,Mitsuaki; Iwai,Muneo; Yoshida,Keiko; Kagotani,Akiko; Okabe,Hidetoshi

doi:10.3892/ol.2013.1719

2014-February Volume 7 Issue 2

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2014-February Volume 7 Issue 2

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Case Report

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

Authors:
- Mitsuaki Ishida
- Muneo Iwai
- Keiko Yoshida
- Akiko Kagotani
- Hidetoshi Okabe
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
Pages: 342-344
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Published online on: November 29, 2013

https://doi.org/10.3892/ol.2013.1719
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Abstract

Median raphe cyst is a rare lesion located on the median raphe. The cyst wall is lined by cuboidal to columnar cells, transitional (urothelial) cells, stratified squamous cells or a mixture of these. The normal urethral mucosa and the median raphe cyst usually lack melanocytes and/or melanin pigment. However, albeit extremely rare, the presence of melanin pigment and/or melanocytes in median raphe cyst, namely pigmented median raphe cyst, has been previously reported. The current case report presents the sixth case of pigmented median raphe cyst and discusses the possible mechanism of melanocytic colonization in this tumor. A 48‑year‑old male presented with a nodule on the ventral surface of the penis. Histopathological study revealed that the cyst wall was covered by uniform bland cuboidal to urothelial cells. The peculiar observation was the presence of dendritic melanocytes among the epithelial cells. Therefore, a diagnosis of pigmented median raphe cyst was determined. Immunohistochemically, stem cell factor and endothelin‑1 were not expressed in the epithelial cells of the cyst wall. It is well‑known that melanocytes are rarely found in various non‑melanocytic tumors, a phenomenon termed ‘colonization’. The mechanism by which melanocytes appear in median raphe cyst remains unclear. The present report is the first to demonstrate that melanocytic proliferation and differentiation factors, such as stem cell factor and endothelin‑1, are not involved in the pigmentation of median raphe cyst. In addition, aberrant melanocytic migration may contribute to the development of this type of lesion.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

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