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Article

Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma

  • Authors:
    • Angelina Di Carlo
  • View Affiliations / Copyright

    Affiliations: Department of Medico‑Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina I‑04100, Italy
  • Pages: 621-626
    |
    Published online on: December 11, 2013
       https://doi.org/10.3892/ol.2013.1755
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Abstract

The matrix metalloproteinase (MMP) family has been shown to play a critical role in tissue remodeling and tumor infiltration. Their activity is normally strictly controlled by tissue inhibitors of metalloproteinases (TIMPs). However, TIMPs act indirectly through modulation of protease activity or directly through cell surface receptors to direct cell fate. These molecules have been proposed as markers of malignant cancer. Previous studies on MMP and TIMP expression in kidney carcinoma have been limited and have reported variable observations. The current study measured the content of MMP‑2 and ‑9 and TIMP‑1 and ‑2 in the sera and urine of patients with kidney carcinoma by enzyme‑linked immunosorbent assay. Of these patients, 16 exhibited clear cell renal cell carcinoma (ccRCC) and 4 exhibited oncocytoma. Sera and urine samples of 53 healthy subjects were used as controls. In the sera of the control group, MMP‑2 and TIMP‑2 were detectable in all samples, while MMP‑9 and TIMP‑1 were below the sensitivity of the assay. In the pathological specimens, the mean serum values of MMP‑2 and TIMP‑1 and ‑2 were similar in the ccRCC and oncocytoma patients, whereas the value for MMP‑9 was 2‑fold higher in the ccRCC patients compared with the oncocytoma patients. With regard to the urine specimens, all four molecules were undetectable in the normal healthy samples and in a few pathological samples. The mean values for MMP‑2 and ‑9 and TIMP‑2 in the positive urine specimens were similar in the ccRCC and oncocytoma patients, whereas the mean value of TIMP‑1 was higher in the ccRCC patients compared with that of the oncocytoma patients. The mean urinary levels of the four molecules were less than those of the sera. Statistical analysis of the data did not reveal any correlation between the tumor grades and expression levels of the molecules examined.
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1 

Jemal A, Siegel R, Xu and Wrad E: Cancer statistics, 2010. Ca Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

2 

Cohen HT and McGoven FJ: Renal-cell carcinoma. N Engl J Med. 353:2477–2490. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Nagase H and Woessner JF Jr: Matrix metalloproteinases. J Biol Chem. 274:21491–21494. 1999. View Article : Google Scholar

4 

Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Björklund M and Koivunen E: Gelatinase-mediated migration and invasion of cancer cell. Biochim Biophys Acta. 1755:37–69. 2005.PubMed/NCBI

6 

Brew K, Dinakarpandian D and Nagase H: Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochem Biophys Acta. 1477:267–283. 2000.PubMed/NCBI

7 

Baker AH, Ahonen M and Kähäri VM: Potential applications of tissue inhibitor of metalloproteinase (TIMP) overexpression for cancer gene therapy. Adv Exp Med Biol. 465:469–483. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Hayakawa T, Yamashita K, Tanzawa K, Uchijima E and Iwata K: Growth-promoting activity of tissue inhibitor of metalloproteinase-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum. FEBS Lett. 298:29–32. 1992. View Article : Google Scholar

9 

Visse R and Nagase H: Matrix metalloproteinases and tissue inhibitors of metalloproteinases. Structure, functions and biochemistry. Cir Res. 92:827–839. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Stetler-Stevenson WG: Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase independent biological activities. Sci Signal. 1:re62008. View Article : Google Scholar : PubMed/NCBI

11 

Sobin LH and Wittekind CH: International Union Against Cancer (UICC) TNM classification of malignant tumors. 6th edition. Wiley-Liss; New York, NY: pp. 193–195. 2002

12 

Di Carlo A: Matrix metalloproteinase -2 and -9 in the sera and in the urine of human oncocytoma and renal cell carcinoma. Oncol Rep. 28:1051–1056. 2012.PubMed/NCBI

13 

Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P and Moch H: pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J Pathol. 214:464–471. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Kallakury BV, Karikehalli S, Haholu A, Sheehan CE, Azumi N and Ross JS: Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res. 7:3113–3119. 2001.

15 

Bhuvarahamurthy V, Kristiansen GO, Johannsen M, Loening SA, Schnorr D, Jung K and Staack A: In situ gene expression and localization of metalloproteinases MMP1, MMP2, MMP3, MMP9 and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma. Oncol Rep. 15:1379–1384. 2006.PubMed/NCBI

16 

Kugler A, Hemmerlein B, Thelen P, Kallerhoff M, Radzun HJ and Ringert RH: Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinoma. J Urol. 160:1914–1918. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Kamiya N, Kishimoto T, Suzuki H, Sekita N, Nagai Y, Oosumi N, Kito H, Tochigi N, Shinbo M, Nemori R, Ichikawa T, Igarashi T, Ito H and Ishikura H: Increased in situ gelatinolytic activity in renal cell tumor tissues correlates with tumor size, grade and vessel invasion. Int J Cancer. 106:480–485. 2003. View Article : Google Scholar

18 

Lein M, Jung K, Laube C, Hübner T, Winkelmann B, Stephan C, Hauptmann S, Rudolph B, Schnorr D and Loening SA: Matrix-metalloproteinases and their inhibitors in plasma and tumor tissue of patients with renal cell carcinoma. Int J Cancer. 85:801–804. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Cannon GM Jr and Getzenberg RH: Urinary matrix metalloproteinases activity is not significantly altered in patients with renal cell carcinoma. Urology. 67:848–850. 2006. View Article : Google Scholar

20 

Sherief MH, Low SS, Miura M, Kudo N, Novick A and Weimbs T: Matrix metalloproteinase activity in urine of patients with renal cell carcinoma leads to degradation of extracellular matrix proteins: possible use as a screening assay. J Urol. 169:1530–1534. 2003. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Di Carlo A: Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma. Oncol Lett 7: 621-626, 2014.
APA
Di Carlo, A. (2014). Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma. Oncology Letters, 7, 621-626. https://doi.org/10.3892/ol.2013.1755
MLA
Di Carlo, A."Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma". Oncology Letters 7.3 (2014): 621-626.
Chicago
Di Carlo, A."Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma". Oncology Letters 7, no. 3 (2014): 621-626. https://doi.org/10.3892/ol.2013.1755
Copy and paste a formatted citation
x
Spandidos Publications style
Di Carlo A: Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma. Oncol Lett 7: 621-626, 2014.
APA
Di Carlo, A. (2014). Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma. Oncology Letters, 7, 621-626. https://doi.org/10.3892/ol.2013.1755
MLA
Di Carlo, A."Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma". Oncology Letters 7.3 (2014): 621-626.
Chicago
Di Carlo, A."Matrix metalloproteinase‑2 and ‑9 and tissue inhibitor of metalloproteinase‑1 and ‑2 in sera and urine of patients with renal carcinoma". Oncology Letters 7, no. 3 (2014): 621-626. https://doi.org/10.3892/ol.2013.1755
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