Role of IL‑9 and STATs in hematological malignancies (Review)

  • Authors:
    • Na Chen
    • Xin Wang
  • View Affiliations

  • Published online on: December 16, 2013     https://doi.org/10.3892/ol.2013.1761
  • Pages: 602-610
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Abstract

Although interleukin‑9 (IL‑9) exhibits pleiotropic functions in the immune system, it remains a well‑known cytokine in hematological malignancies. Previous cell culture and animal model studies have revealed that the Janus kinase‑signal transducer and activator of transcription signaling pathway, which may be activated by a number of cytokines including IL‑9, is critical in hematological malignancies. The current review summarizes the characterization of the biological activities of IL‑9, highlights the clearly defined roles of the cytokine, and outlines questions with regard to the functions of IL‑9 that require further exploration and their downstream signaling proteins, signal transducers and activators of transcription.
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2014-March
Volume 7 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen N and Chen N: Role of IL‑9 and STATs in hematological malignancies (Review). Oncol Lett 7: 602-610, 2014
APA
Chen, N., & Chen, N. (2014). Role of IL‑9 and STATs in hematological malignancies (Review). Oncology Letters, 7, 602-610. https://doi.org/10.3892/ol.2013.1761
MLA
Chen, N., Wang, X."Role of IL‑9 and STATs in hematological malignancies (Review)". Oncology Letters 7.3 (2014): 602-610.
Chicago
Chen, N., Wang, X."Role of IL‑9 and STATs in hematological malignancies (Review)". Oncology Letters 7, no. 3 (2014): 602-610. https://doi.org/10.3892/ol.2013.1761