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2014-March Volume 7 Issue 3

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Review

Role of IL‑9 and STATs in hematological malignancies (Review)

  • Authors:
    • Na Chen
    • Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 602-610
    |
    Published online on: December 16, 2013
       https://doi.org/10.3892/ol.2013.1761
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Abstract

Although interleukin‑9 (IL‑9) exhibits pleiotropic functions in the immune system, it remains a well‑known cytokine in hematological malignancies. Previous cell culture and animal model studies have revealed that the Janus kinase‑signal transducer and activator of transcription signaling pathway, which may be activated by a number of cytokines including IL‑9, is critical in hematological malignancies. The current review summarizes the characterization of the biological activities of IL‑9, highlights the clearly defined roles of the cytokine, and outlines questions with regard to the functions of IL‑9 that require further exploration and their downstream signaling proteins, signal transducers and activators of transcription.
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Copy and paste a formatted citation
Spandidos Publications style
Chen N and Wang X: Role of IL‑9 and STATs in hematological malignancies (Review). Oncol Lett 7: 602-610, 2014.
APA
Chen, N., & Wang, X. (2014). Role of IL‑9 and STATs in hematological malignancies (Review). Oncology Letters, 7, 602-610. https://doi.org/10.3892/ol.2013.1761
MLA
Chen, N., Wang, X."Role of IL‑9 and STATs in hematological malignancies (Review)". Oncology Letters 7.3 (2014): 602-610.
Chicago
Chen, N., Wang, X."Role of IL‑9 and STATs in hematological malignancies (Review)". Oncology Letters 7, no. 3 (2014): 602-610. https://doi.org/10.3892/ol.2013.1761
Copy and paste a formatted citation
x
Spandidos Publications style
Chen N and Wang X: Role of IL‑9 and STATs in hematological malignancies (Review). Oncol Lett 7: 602-610, 2014.
APA
Chen, N., & Wang, X. (2014). Role of IL‑9 and STATs in hematological malignancies (Review). Oncology Letters, 7, 602-610. https://doi.org/10.3892/ol.2013.1761
MLA
Chen, N., Wang, X."Role of IL‑9 and STATs in hematological malignancies (Review)". Oncology Letters 7.3 (2014): 602-610.
Chicago
Chen, N., Wang, X."Role of IL‑9 and STATs in hematological malignancies (Review)". Oncology Letters 7, no. 3 (2014): 602-610. https://doi.org/10.3892/ol.2013.1761
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