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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-March Volume 7 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

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Article

miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells

  • Authors:
    • Lifeng Miao
    • Xianze Xiong
    • Yixin Lin
    • Yao Cheng
    • Jiong Lu
    • Jie Zhang
    • Nansheng Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Bile Duct Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 658-662
    |
    Published online on: January 16, 2014
       https://doi.org/10.3892/ol.2014.1807
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Abstract

Pancreatic cancer is one of the most lethal malignant diseases with the poorest prognosis and is the fourth leading cause of tumor‑associated mortality in the industrialized world. microRNAs (miRNAs or miRs) are small noncoding RNAs of approximately 22 nucleotides long that are able to function as oncogenes or tumor suppressors in human cancer. In our study, overexpression of miR‑203 in Panc‑1 cells is sufficient to reduce migratory ability and invasiveness, and to induce upregulation of epithelial markers (Snail, ZO‑1 and β‑catenin) followed by a decrease of mesenchymal marker expression (Zeb‑1, vimentin and fibronectin). We also found that the caveolin‑1 mRNA or protein levels are modulated by miR‑203 in Panc‑1 cells. We found that exogenous miR‑203 altered the level of cell migration and invasion, and the expression of associated proteins following caveolin‑1 knockdown by small interfering RNA. These results demonstrate that miR‑203 inhibits cell migration and invasion via caveolin‑1 in pancreatic cancer cells, suggest that miR‑203 expression may be a useful indicator of the metastatic potential and provide a new therapeutic target in this common malignancy.
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Copy and paste a formatted citation
Spandidos Publications style
Miao L, Xiong X, Lin Y, Cheng Y, Lu J, Zhang J and Cheng N: miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells. Oncol Lett 7: 658-662, 2014.
APA
Miao, L., Xiong, X., Lin, Y., Cheng, Y., Lu, J., Zhang, J., & Cheng, N. (2014). miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells. Oncology Letters, 7, 658-662. https://doi.org/10.3892/ol.2014.1807
MLA
Miao, L., Xiong, X., Lin, Y., Cheng, Y., Lu, J., Zhang, J., Cheng, N."miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells". Oncology Letters 7.3 (2014): 658-662.
Chicago
Miao, L., Xiong, X., Lin, Y., Cheng, Y., Lu, J., Zhang, J., Cheng, N."miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells". Oncology Letters 7, no. 3 (2014): 658-662. https://doi.org/10.3892/ol.2014.1807
Copy and paste a formatted citation
x
Spandidos Publications style
Miao L, Xiong X, Lin Y, Cheng Y, Lu J, Zhang J and Cheng N: miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells. Oncol Lett 7: 658-662, 2014.
APA
Miao, L., Xiong, X., Lin, Y., Cheng, Y., Lu, J., Zhang, J., & Cheng, N. (2014). miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells. Oncology Letters, 7, 658-662. https://doi.org/10.3892/ol.2014.1807
MLA
Miao, L., Xiong, X., Lin, Y., Cheng, Y., Lu, J., Zhang, J., Cheng, N."miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells". Oncology Letters 7.3 (2014): 658-662.
Chicago
Miao, L., Xiong, X., Lin, Y., Cheng, Y., Lu, J., Zhang, J., Cheng, N."miR‑203 inhibits tumor cell migration and invasion via caveolin‑1 in pancreatic cancer cells". Oncology Letters 7, no. 3 (2014): 658-662. https://doi.org/10.3892/ol.2014.1807
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