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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-April Volume 7 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells

  • Authors:
    • Sung Su Kim
    • Sin Seong
    • Sung Young Kim
  • View Affiliations / Copyright

    Affiliations: Department of Oriental Medicine, Kyung Hee University College of Oriental Medicine, Seoul 130‑701, Republic of Korea, Department of Biochemistry, School of Medicine, Konkuk University, Seoul 143‑701, Republic of Korea
  • Pages: 1265-1269
    |
    Published online on: January 24, 2014
       https://doi.org/10.3892/ol.2014.1826
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Abstract

The pharmacological modulatory effects of 20(S)‑ginsenoside Rg3 (20S‑Rg3) on multidrug resistant cancer cells are reported in the present study. The effects of 20(S)‑Rg3 on the modulation of doxorubicin (DOX) and vincristine (VCR) resistance were examined in the HL60 multidrug resistant subline of human acute myeloid leukemia cells. Results demonstrated that 20S‑Rg3 is as effective as verapamil (Vp) for modulating the high degree primary DOX resistance and low degree VCR cross‑resistance expressed by the H160 cell line. Furthermore, the present study demonstrates for the first time, using isobologram analysis, that the combination of 20S‑Rg3 and Vp enhances the reversal of DOX and VCR resistance in a supra‑additive or at least an additive manner. These results indicate that 20S‑Rg3 may be used as a Vp synergizer or as a promising alternative to Vp in the chemosensitization of multidrug resistant acute myeloid leukemia, with far fewer side effects.
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Copy and paste a formatted citation
Spandidos Publications style
Kim SS, Seong S and Kim SY: Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells. Oncol Lett 7: 1265-1269, 2014.
APA
Kim, S.S., Seong, S., & Kim, S.Y. (2014). Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells. Oncology Letters, 7, 1265-1269. https://doi.org/10.3892/ol.2014.1826
MLA
Kim, S. S., Seong, S., Kim, S. Y."Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells". Oncology Letters 7.4 (2014): 1265-1269.
Chicago
Kim, S. S., Seong, S., Kim, S. Y."Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells". Oncology Letters 7, no. 4 (2014): 1265-1269. https://doi.org/10.3892/ol.2014.1826
Copy and paste a formatted citation
x
Spandidos Publications style
Kim SS, Seong S and Kim SY: Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells. Oncol Lett 7: 1265-1269, 2014.
APA
Kim, S.S., Seong, S., & Kim, S.Y. (2014). Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells. Oncology Letters, 7, 1265-1269. https://doi.org/10.3892/ol.2014.1826
MLA
Kim, S. S., Seong, S., Kim, S. Y."Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells". Oncology Letters 7.4 (2014): 1265-1269.
Chicago
Kim, S. S., Seong, S., Kim, S. Y."Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells". Oncology Letters 7, no. 4 (2014): 1265-1269. https://doi.org/10.3892/ol.2014.1826
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