Simultaneous bilateral testicular metastases from renal clear cell carcinoma: A case report and review of the literature

Moriyama,Shingo; Takeshita,Hideki; Adachi,Akiko; Arai,Yoshiaki; Higuchi,Saori; Tokairin,Takuo; Chiba,Koji; Nakagawa,Koji; Noro,Akira

doi:10.3892/ol.2014.1830

2014-April Volume 7 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

2014-April Volume 7 Issue 4

Full Size Image

Case Report

Simultaneous bilateral testicular metastases from renal clear cell carcinoma: A case report and review of the literature

Authors:
- Shingo Moriyama
- Hideki Takeshita
- Akiko Adachi
- Yoshiaki Arai
- Saori Higuchi
- Takuo Tokairin
- Koji Chiba
- Koji Nakagawa
- Akira Noro
View Affiliations / Copyright

Affiliations: Department of Urology, Saitama Red Cross Hospital, Saitama City, Saitama 338‑8553, Japan, Department of Pathology, Saitama Red Cross Hospital, Saitama City, Saitama 338‑8553, Japan, Department of Urology, Nishi-Ohmiya Hospital, Saitama City, Saitama 330‑0856, Japan, Department of Surgery, Saitama Red Cross Hospital, Saitama City, Saitama 338‑8553, Japan
Pages: 1273-1275
|
Published online on: January 27, 2014

https://doi.org/10.3892/ol.2014.1830
Expand metrics +

Abstract

Metastasis from renal cell carcinoma (RCC) to the testis is rare. This case report presented an extremely rare case of simultaneous bilateral testicular metastases from RCC in a 65‑year‑old man who had experienced indolent scrotal enlargement over a period of several months. Scrotal ultrasonography showed 4.0‑ and 2.0‑cm‑sized masses in the left and right testes, respectively. Contrast‑enhanced computed tomography identified multiple tumors in the kidneys, the pancreas and the left adrenal gland. Left orchiectomy and pathological examination were performed and indicated testicular metastasis from clear cell RCC. The patient underwent complete surgical resection of all residual lesions. Postoperative follow‑up examination without adjuvant therapy identified no recurrence over 11 months. This study also reviewed existing literature and determined that retrograde venous spread from the primary kidney tumor to the testis may be an important pathway for testicular metastasis from RCC. In conclusion, RCC can result in testicular metastases not only unilaterally, but also bilaterally, as was observed in the present case.

View Figures

View References

1	Dieckmann KP, Düe W and Loy V: Intrascrotal metastasis of renal cell carcinoma. Case reports and review of the literature. Eur Urol. 15:297–301. 1988.PubMed/NCBI
2	Pienkos EJ and Jablokow VR: Secondary testicular tumors. Cancer. 30:481–485. 1972. View Article : Google Scholar
3	Dutt N, Bates AW and Baithun SI: Secondary neoplasms of the male genital tract with different patterns of involvement in adults and children. Histopathology. 37:323–331. 2000. View Article : Google Scholar : PubMed/NCBI
4	Haupt HM, Mann RB, Trump DL and Abeloff MD: Metastatic carcinoma involving the testis. Clinical and pathologic distinction from primary testicular neoplasms. Cancer. 54:709–714. 1984. View Article : Google Scholar
5	Blefari F, Risi O and Pino P: Secondary tumors of testis: two rare cases and review of the literature. Urol Int. 48:469–470. 1992. View Article : Google Scholar : PubMed/NCBI
6	Camerini A, Tartarelli G, Martini L, Donati S, Puccinelli P and Amoroso D: Ipsilateral right testicular metastasis from renal cell carcinoma in a responder patient to interleukine-2 treatment. Int J Urol. 14:259–260. 2007. View Article : Google Scholar
7	Datta MW, Ulbright TM and Young RH: Renal cell carcinoma metastatic to the testis and its adnexa: a report of five cases including three that accounted for the initial clinical presentation. Int J Surg Pathol. 9:49–56. 2001. View Article : Google Scholar
8	Hanash KA, Carney JA and Kelalis PP: Metastatic tumors to testicles: routes of metastasis. J Urol. 102:465–468. 1969.PubMed/NCBI
9	Giannakopoulos X, Bai M, Grammeniatis E, Stefanou D and Agnanti N: Bilateral testicular metastasis of an adenocarcinoma of the prostate. Ann Urol. 28:(Paris). 274–276. 1994.(In French).
10	Hatoum HA, Abi Saad GS, Otrock ZK, Barada KA and Shamseddine AI: Metastasis of colorectal carcinoma to the testes: clinical presentation and possible pathways. Int J Clin Oncol. 16:203–209. 2011. View Article : Google Scholar : PubMed/NCBI
11	Nabi G, Gania MA and Sharma MC: Solitary delayed contralateral testicular metastasis from renal cell carcinoma. Indian J Pathol Microbiol. 44:487–488. 2001.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Simultaneous bilateral testicular metastases from renal clear cell carcinoma: A case report and review of the literature

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles