Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome

  • Authors:
    • Xin Yan Zhao
    • Mohmedmohsin Ismail Ahmed Rakhda
    • Sohail Habib
    • Ali Bihi
    • Abdullah Muhammad
    • Tai Ling Wang
    • Ji‑Dong Jia
  • View Affiliations / Copyright

    Affiliations: Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, International School of Capital Medical University, Beijing 100069, P.R. China, Department of Pathology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China
  • Pages: 977-983
    |
    Published online on: February 3, 2014
       https://doi.org/10.3892/ol.2014.1847
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatic epithelioid hemangioendothelioma (HEHE) is a rare tumor of vascular origin. Whether HEHE in Chinese patients exhibits similar characteristics compared with Western patients is not well known. The aim of the present study was to summarize the characteristics of HEHE in Chinese patients and identify its prognostic factors. In total, six patients diagnosed with HEHE at the Beijing Friendship Hospital between 2000 and 2012 were combined with 44 previously reported cases in China, retrieved from the literature between 1989 and mid‑2012. These 50 cases from China were compared with 402 patients from Western populations. Prognostic factors were identified by the χ2 test and Cox regression analysis. The male to female ratio of the Chinese patients was 1:2.1 with the mean age of 44.2 years (range, 22‑86 years). The percentage of asymptomatic Chinese patients was significantly higher than in the Western patients (40.0 vs. 24.8%; P=0.026), and that of extrahepatic metastasis (16.0 vs. 36.6%; P=0.005) was significantly lower in Chinese patients. On imaging study, capsular retraction (59.5%) and calcification (26.0%), as well as positivity of CD34 (93.5%) and CD31 (80.6%), were more frequently found in the Chinese patients. Management for the Chinese patients included liver resection (LRx; 45.7%), liver transplantation (LTx; 5.7%), trans‑catheter arterial chemoembolization (14.3%) and palliative treatment (34.3%). Chinese patients with larger‑sized tumor nodules [relative risk (RR), 1.58; 95% confidence interval (CI), 1.032‑2.422; P=0.035) and diffuse type (RR, 12.17; 95% CI, 1.595‑92.979; P=0.016) exhibited unfavorable outcomes. In contrast to Western patients with HEHE, a larger number of Chinese patients were asymptomatic with less extrahepatic metastasis. In China, LRx is widely adopted rather than LTx. Chinese patients with large tumor size or diffuse type may encounter a poorer prognosis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Weiss SW and Enzinger FM: Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 50:970–981. 1982. View Article : Google Scholar

2 

Komatsu Y, Koizumi T, Yasuo M, et al: Malignant hepatic epithelioid hemangioendothelioma with rapid progression and fatal outcome. Intern Med. 49:1149–1153. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Makhlouf HR, Ishak KG and Goodman ZD: Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer. 85:562–582. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Thin LW, Wong DD, De Boer BW, et al: Hepatic epithelioid haemangioendothelioma: challenges in diagnosis and management. Intern Med J. 40:710–715. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Mehrabi A, Kashfi A, Fonouni H, Schemmer P, Schmied BM and Hallscheidt P: Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer. 107:2108–2121. 2006. View Article : Google Scholar

6 

Zhao AL, Zhou LX and Li XH: Hepatic epithelioid hemangioendothelioma in needle biopsy specimens: report of 5 cases with review of literature. Zhonghua Bing Li Xue Za Zhi. 40:23–26. 2011.(In Chinese).

7 

Chen Y, Yu RS, Qiu LL, Jiang DY, Tan YB and Fu YB: Contrast-enhanced multiple-phase imaging features in hepatic epithelioid hemangioendothelioma. World J Gastroenterol. 17:3544–3553. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Shi Y and Hou YY: Hepatic epithelioid hemangioendothelioma: a case report. Zhonghua Bing Li Xue Za Zhi. 34:3832005.(In Chinese).

9 

Lin J and Ji Y: CT and MRI diagnosis of hepatic epithelioid hemangioendothelioma. Hepatobiliary Pancreat Dis Int. 9:154–158. 2010.PubMed/NCBI

10 

Ji ZF, Shen XZ, Zhang DY, Liu HY, Zhou Y, Guo MY and Dong L: Hepatic epithelioid hemangioendothelioma: a report of six patients. J Dig Dis. 11:254–258. 2010.PubMed/NCBI

11 

Lau WY, Dewar GA and Li AK: Spontaneous rupture of hepatic epithelioid haemangio-endothelioma. Aust N Z J Surg. 59:972–9744. 1989. View Article : Google Scholar : PubMed/NCBI

12 

Hsieh MS, Liang PC, Kao YC and Shun CT: Hepatic epithelioid hemangioendothelioma in Taiwan: a clinicopathologic study of six cases in a single institution over a 15-year period. J Formos Med Assoc. 109:219–227. 2010.

13 

Lee HF, Lu CL and Chang FY: Electronic clinical challenges and images in GI. Multiple hepatic tumors with hemoperitoneum. Gastroenterology. 138:e3–e4. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Shen CH, Tsai MH, Chen TC, Liu NJ and Sheen IS: Primary hepatic epithelioid hemangioendothelioma: case report. Changgeng Yi Xue Za Zhi. 22:486–491. 1999.PubMed/NCBI

15 

Zang SH, Cong WM and Wu MC: Epithelioid hemangioendothelioma of the liver : a clinicopathological study on 8 cases and review of literature. Zhonghua Gan Dan Wai Ke Za Zhi. 6:327–330. 2003.

16 

Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L and Stromeyer FW: Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum Pathol. 15:839–852. 1984. View Article : Google Scholar : PubMed/NCBI

17 

Rodriguez JA, Becker NS, O’Mahony CA, Goss JA and Aloia TA: Long-term outcomes following liver transplantation for hepatic hemangioendothelioma: the UNOS experience from 1987 to 2005. J Gastrointest Surg. 12:110–116. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Lerut JP, Orlando G, Adam R, et al: The place of liver transplantation in the treatment of hepatic epitheloid hemangioendothelioma: report of the European liver transplant registry. Ann Surg. 246:949–957; discussion 57. 2007. View Article : Google Scholar

19 

Madariaga JR, Marino IR, Karavias DD, et al: Long-term results after liver transplantation for primary hepatic epithelioid hemangioendothelioma. Ann Surg Oncol. 2:483–487. 1995. View Article : Google Scholar

20 

Nudo CG, Yoshida EM, Bain VG, et al: Liver transplantation for hepatic epithelioid hemangioendothelioma: the Canadian multicentre experience. Can J Gastroenterol. 22:821–824. 2008.PubMed/NCBI

21 

Salech F, Valderrama S, Nervi B, et al: Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: a case report with a long term follow-up. Ann Hepatol. 10:99–102. 2011.

22 

Raphael C, Hudson E, Williams L, Lester JF and Savage PM: Successful treatment of metastatic hepatic epithelioid hemangioendothelioma with thalidomide: a case report. J Med Case Rep. 4:4132010. View Article : Google Scholar : PubMed/NCBI

23 

Mascarenhas RC, Sanghvi AN, Friedlander L, Geyer SJ, Beasley HS and Van Thiel DH: Thalidomide inhibits the growth and progression of hepatic epithelioid hemangioendothelioma. Oncology. 67:471–475. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Grotz TE, Nagorney D, Donohue J, et al: Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option? HPB (Oxford). 12:546–553. 2010. View Article : Google Scholar

25 

Wang LR, Zhou JM, Zhao YM, et al: Clinical experience with primary hepatic epithelioid hemangioendothelioma: retrospective study of 33 patients. World J Surg. 36:2677–2683. 2012. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao XY, Rakhda MI, Habib S, Bihi A, Muhammad A, Wang TL and Jia JD: Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome. Oncol Lett 7: 977-983, 2014.
APA
Zhao, X.Y., Rakhda, M.I., Habib, S., Bihi, A., Muhammad, A., Wang, T.L., & Jia, J. (2014). Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome. Oncology Letters, 7, 977-983. https://doi.org/10.3892/ol.2014.1847
MLA
Zhao, X. Y., Rakhda, M. I., Habib, S., Bihi, A., Muhammad, A., Wang, T. L., Jia, J."Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome". Oncology Letters 7.4 (2014): 977-983.
Chicago
Zhao, X. Y., Rakhda, M. I., Habib, S., Bihi, A., Muhammad, A., Wang, T. L., Jia, J."Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome". Oncology Letters 7, no. 4 (2014): 977-983. https://doi.org/10.3892/ol.2014.1847
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao XY, Rakhda MI, Habib S, Bihi A, Muhammad A, Wang TL and Jia JD: Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome. Oncol Lett 7: 977-983, 2014.
APA
Zhao, X.Y., Rakhda, M.I., Habib, S., Bihi, A., Muhammad, A., Wang, T.L., & Jia, J. (2014). Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome. Oncology Letters, 7, 977-983. https://doi.org/10.3892/ol.2014.1847
MLA
Zhao, X. Y., Rakhda, M. I., Habib, S., Bihi, A., Muhammad, A., Wang, T. L., Jia, J."Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome". Oncology Letters 7.4 (2014): 977-983.
Chicago
Zhao, X. Y., Rakhda, M. I., Habib, S., Bihi, A., Muhammad, A., Wang, T. L., Jia, J."Hepatic epithelioid hemangioendothelioma: A comparison of Western and Chinese methods with respect to diagnosis, treatment and outcome". Oncology Letters 7, no. 4 (2014): 977-983. https://doi.org/10.3892/ol.2014.1847
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team