Antitumor effects of high‑temperature hyperthermia on a glioma rat model

Takagi,Hidefumi; Azuma,Kazuo; Tsuka,Takeshi; Imagawa,Tomohiro; Osaki,Tomohiro; Okamoto,Yoshiharu

doi:10.3892/ol.2014.1852

Antitumor effects of high‑temperature hyperthermia on a glioma rat model

Authors:
- Hidefumi Takagi
- Kazuo Azuma
- Takeshi Tsuka
- Tomohiro Imagawa
- Tomohiro Osaki
- Yoshiharu Okamoto
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Affiliations: The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753‑8515, Japan, Faculty of Agriculture, Tottori University, Tottori 680‑8533, Japan
Published online on: February 4, 2014 https://doi.org/10.3892/ol.2014.1852
Pages: 1007-1010

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Abstract

High‑temperature hyperthermia (HTH) is an established treatment option for cancer. The aim of the present study was to reveal the exact correlation between HTH at temperatures of 50‑70˚C and the resulting antitumor effects, using a glioma rat model. In the 60˚C (T‑60) and 70˚C (T‑70) HTH groups, tumor growth rates were significantly suppressed compared with those in the nontreatment (NT) group. In the 50˚C (T‑50) HTH group, tumor growth rates were not suppressed compared with those in the NT group. The numbers of terminal dUTP nick‑end labeling‑positive cells in tumor tissue were significantly higher in the T‑50, T‑60 and T‑70 groups than those in the NT group. The Ki‑67‑positive areas were significantly decreased in the T‑70 group compared with those in the NT and T‑60 groups. Our data indicate that HTH at 60 and 70˚C suppresses tumor growth in a glioma rat model. In particular, cell proliferation was significantly suppressed by HTH at 70˚C. However, differences in the mechanism of action of HTH at 60 and 70˚C were observed.

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