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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-April Volume 7 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Antitumor effects of high‑temperature hyperthermia on a glioma rat model

  • Authors:
    • Hidefumi Takagi
    • Kazuo Azuma
    • Takeshi Tsuka
    • Tomohiro Imagawa
    • Tomohiro Osaki
    • Yoshiharu Okamoto
  • View Affiliations / Copyright

    Affiliations: The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753‑8515, Japan, Faculty of Agriculture, Tottori University, Tottori 680‑8533, Japan
  • Pages: 1007-1010
    |
    Published online on: February 4, 2014
       https://doi.org/10.3892/ol.2014.1852
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Abstract

High‑temperature hyperthermia (HTH) is an established treatment option for cancer. The aim of the present study was to reveal the exact correlation between HTH at temperatures of 50‑70˚C and the resulting antitumor effects, using a glioma rat model. In the 60˚C (T‑60) and 70˚C (T‑70) HTH groups, tumor growth rates were significantly suppressed compared with those in the nontreatment (NT) group. In the 50˚C (T‑50) HTH group, tumor growth rates were not suppressed compared with those in the NT group. The numbers of terminal dUTP nick‑end labeling‑positive cells in tumor tissue were significantly higher in the T‑50, T‑60 and T‑70 groups than those in the NT group. The Ki‑67‑positive areas were significantly decreased in the T‑70 group compared with those in the NT and T‑60 groups. Our data indicate that HTH at 60 and 70˚C suppresses tumor growth in a glioma rat model. In particular, cell proliferation was significantly suppressed by HTH at 70˚C. However, differences in the mechanism of action of HTH at 60 and 70˚C were observed.
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Copy and paste a formatted citation
Spandidos Publications style
Takagi H, Azuma K, Tsuka T, Imagawa T, Osaki T and Okamoto Y: Antitumor effects of high‑temperature hyperthermia on a glioma rat model. Oncol Lett 7: 1007-1010, 2014.
APA
Takagi, H., Azuma, K., Tsuka, T., Imagawa, T., Osaki, T., & Okamoto, Y. (2014). Antitumor effects of high‑temperature hyperthermia on a glioma rat model. Oncology Letters, 7, 1007-1010. https://doi.org/10.3892/ol.2014.1852
MLA
Takagi, H., Azuma, K., Tsuka, T., Imagawa, T., Osaki, T., Okamoto, Y."Antitumor effects of high‑temperature hyperthermia on a glioma rat model". Oncology Letters 7.4 (2014): 1007-1010.
Chicago
Takagi, H., Azuma, K., Tsuka, T., Imagawa, T., Osaki, T., Okamoto, Y."Antitumor effects of high‑temperature hyperthermia on a glioma rat model". Oncology Letters 7, no. 4 (2014): 1007-1010. https://doi.org/10.3892/ol.2014.1852
Copy and paste a formatted citation
x
Spandidos Publications style
Takagi H, Azuma K, Tsuka T, Imagawa T, Osaki T and Okamoto Y: Antitumor effects of high‑temperature hyperthermia on a glioma rat model. Oncol Lett 7: 1007-1010, 2014.
APA
Takagi, H., Azuma, K., Tsuka, T., Imagawa, T., Osaki, T., & Okamoto, Y. (2014). Antitumor effects of high‑temperature hyperthermia on a glioma rat model. Oncology Letters, 7, 1007-1010. https://doi.org/10.3892/ol.2014.1852
MLA
Takagi, H., Azuma, K., Tsuka, T., Imagawa, T., Osaki, T., Okamoto, Y."Antitumor effects of high‑temperature hyperthermia on a glioma rat model". Oncology Letters 7.4 (2014): 1007-1010.
Chicago
Takagi, H., Azuma, K., Tsuka, T., Imagawa, T., Osaki, T., Okamoto, Y."Antitumor effects of high‑temperature hyperthermia on a glioma rat model". Oncology Letters 7, no. 4 (2014): 1007-1010. https://doi.org/10.3892/ol.2014.1852
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