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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-April Volume 7 Issue 4

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Case Report

Leiomyosarcoma of the thyroid gland: A case report and literature review

  • Authors:
    • Giovanni Conzo
    • Giancarlo Candela
    • Ernesto Tartaglia
    • Claudio Gambardella
    • Claudio Mauriello
    • Guido Pettinato
    • Giuseppe Bellastella
    • Kathrine Esposito
    • Luigi Santini
  • View Affiliations / Copyright

    Affiliations: Department of Anaesthesiology, Surgical and Emergency Science VII Division of General Surgery, Second University of Naples, Naples I‑80131, Italy, Thoracic Surgery Unit, Second University of Naples, Naples I‑80138, Italy, Department of Cardio‑Thoracic and Respiratory Sciences, Unit of Endocrinology and Diabetes Clinic, Second University of Naples, Naples I‑80131, Italy
  • Pages: 1011-1014
    |
    Published online on: February 4, 2014
       https://doi.org/10.3892/ol.2014.1853
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Abstract

Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor since adjuvant radiochemotherapy is ineffective on local recurrence and on long‑term survival. In this study, we report the case of a 77‑year‑old male affected by a rapidly enlarging mass of the anterior neck, associated with bilateral lung metastases, and increasing dysphagia and dyspnea during the previous 6 months. A Tir4 neoplasm fine needle cytological diagnosis of the right thyroid lobe was reached and the patient underwent total thyroidectomy (TT). Definitive histological examination identified a TL. The patient succumbed 40 days later due to respiratory distress. A literature review was performed and TL differential diagnoses, management, including alternative treatment strategies, and adjuvant therapy were analyzed. TL is an aggressive rare mesenchymal malignant tumor. Although an improved multimodal approach is often necessary, TT and neck dissection represent the treatment of choice and are often the only possible therapy. Adjuvant radiochemotherapy appears to be ineffective and a high mortality rate is observed. TL remains a fatal tumor, and innovative and more effective therapeutic strategies to improve management and outcomes are required.
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1 

Thompson LD, Wenig BM, Adair CF, Shmookler BM and Heffess CS: Primary smooth muscle tumors of the thyroid gland. Cancer. 79:579–587. 1997. View Article : Google Scholar : PubMed/NCBI

2 

DeLellis RA, Lloyd VR, Heitz PU and Eng C: World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs. IARC Press; Lyon: 2004

3 

Amal B, El Fatemi H, Souaf I, Moumna K and Affaf A: A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review. Diagn Pathol. 8:362013. View Article : Google Scholar : PubMed/NCBI

4 

Pezzolla A, Docimo G, Ruggiero R, et al: Incidental thyroid carcinoma: a multicentric experience. Recenti Prog Med. 101:194–198. 2010.(In Italian).

5 

Pasquali D, Santoro A, Bufo P, et al: Upregulation of endocrine gland-derived vascular endothelial growth factor in papillary thyroid cancers displaying infiltrative patterns, lymph node metastases, and Braf mutation. Thyroid. 21:391–399. 2011. View Article : Google Scholar

6 

Conzo G, Circelli L, Pasquali D, et al: Lessons to be learned from the clinical management of a MEN 2A patient bearing a novel 634/640/700 triple mutation of the RET proto-oncogene. Clin Endocrinol (Oxf). 77:934–936. 2012. View Article : Google Scholar

7 

Conzo G, Musella M, Corcione F, De Palma M, Ferraro F, Palazzo A, et al: Laparoscopic adrenalectomy, a safe procedure for pheochromocytoma. A retrospective review of clinical series. Int J Surg. 11:152–156. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Di Vizio D, Insabato L, Conzo G, et al: Sarcomatoid carcinoma of the colon: a case report with literature review. Tumori. 87:431–435. 2001.PubMed/NCBI

9 

Conzo G, Troncone G, Docimo G, et al: Cytologically undetermined follicular lesions: surgical procedures and histological outcome in 472 cases. Ann Ital Chir. 84:251–256. 2012.

10 

Troncone G, Volante M, Iaccarino A, et al: Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine-needle aspirates suspicious for Hurtle cell neoplasms. Cancer Cytopathol. 117:522–529. 2009.

11 

Adachi M, Wellman KF and Garcia R: Metastatic leiomyosarcoma in brain and heart. J Pathol. 98:294–296. 1969. View Article : Google Scholar : PubMed/NCBI

12 

Chetty R, Clark SP and Dowling JP: Leiomyosarcoma of the thyroid: immunohistochemical and ultrastructural study. Pathology. 25:203–205. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Tulbah A, Al-Dayel F, Fawaz I and Rosai J: Epstein-Barr virus-associated leiomyosarcoma of the thyroid in a child with congenital immunodeficiency: a case report. Am J Surg Pathol. 23:473–476. 1999. View Article : Google Scholar

14 

Iida Y, Katoh R, Yoshioka M, Oyama T and Kawaoi A: Primary leiomyosarcoma of the thyroid gland. Acta Pathol Jpn. 43:71–75. 1993.PubMed/NCBI

15 

Deng XR, Wang G, Kuang CG, Peng GZ and Chen RS: Metastasis of leiomyosarcoma to the thyroid. Chin Med J (Engl). 118:174–176. 2005.PubMed/NCBI

16 

Cirocchi R, Boselli C, Guarino S, et al: Total thyroidectomy with ultrasonic dissector for cancer: multicentric experience. World J Surg Oncol. 10:702012. View Article : Google Scholar : PubMed/NCBI

17 

De Bellis A, Conzo G, Cennamo G, et al: Time course of Graves’ ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal study. Endocrine. 41:320–326. 2012.

18 

Conzo G, Pasquali D, Bellastella G, et al: Total thyroidectomy, without prophylactic central lymph node dissection, in the treatment of differentiated thyroid cancer. Clinical retrospective study on 221 cases. Endocrine. 44:419–425. 2013. View Article : Google Scholar

19 

Docimo G, Ruggiero R, Subitosi A, Casalino G, Bosco A, Gili S, Conzo G and Docimo L: Ultrasound scalpel thyroidectomy: prospective randomized study. Ann Ital Chir. 83:491–496. 2012.PubMed/NCBI

20 

Conzo G, Docimo G, Ruggiero R, Napolitano S, Palazzo A, Gambardella C, Mauriello C, Tartaglia E, Cavallo F and Santini L: Surgical treatment of papillary thyroid carcinoma without lymph nodal involvement. G Chir. 33:339–342. 2012.PubMed/NCBI

21 

Wang TS, Ocal IT, Oxley K and Sosa JA: Primary leiomyosarcoma of the thyroid gland. Thyroid. 18:425–428. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Raspollini MR, Aminni G, Villanucci A, Pinzani P, Simi L, Paglierani M and Taddei GL: C-kit overexpression in patients with uterine leiomyosarcomas: a potential alternative therapeutic treatment. Clin Cancer Res. 10:3500–3503. 2004. View Article : Google Scholar

23 

Day AS, Lou PJ, Lin WC and Chou CC: Over-expression of c-kit in a primary leiomyosarcoma of the thyroid gland. Eur Arch Otorhinolaryngol. 264:705–708. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Conzo G, Candela G, Tartaglia E, Gambardella C, Mauriello C, Pettinato G, Bellastella G, Esposito K and Santini L: Leiomyosarcoma of the thyroid gland: A case report and literature review. Oncol Lett 7: 1011-1014, 2014.
APA
Conzo, G., Candela, G., Tartaglia, E., Gambardella, C., Mauriello, C., Pettinato, G. ... Santini, L. (2014). Leiomyosarcoma of the thyroid gland: A case report and literature review. Oncology Letters, 7, 1011-1014. https://doi.org/10.3892/ol.2014.1853
MLA
Conzo, G., Candela, G., Tartaglia, E., Gambardella, C., Mauriello, C., Pettinato, G., Bellastella, G., Esposito, K., Santini, L."Leiomyosarcoma of the thyroid gland: A case report and literature review". Oncology Letters 7.4 (2014): 1011-1014.
Chicago
Conzo, G., Candela, G., Tartaglia, E., Gambardella, C., Mauriello, C., Pettinato, G., Bellastella, G., Esposito, K., Santini, L."Leiomyosarcoma of the thyroid gland: A case report and literature review". Oncology Letters 7, no. 4 (2014): 1011-1014. https://doi.org/10.3892/ol.2014.1853
Copy and paste a formatted citation
x
Spandidos Publications style
Conzo G, Candela G, Tartaglia E, Gambardella C, Mauriello C, Pettinato G, Bellastella G, Esposito K and Santini L: Leiomyosarcoma of the thyroid gland: A case report and literature review. Oncol Lett 7: 1011-1014, 2014.
APA
Conzo, G., Candela, G., Tartaglia, E., Gambardella, C., Mauriello, C., Pettinato, G. ... Santini, L. (2014). Leiomyosarcoma of the thyroid gland: A case report and literature review. Oncology Letters, 7, 1011-1014. https://doi.org/10.3892/ol.2014.1853
MLA
Conzo, G., Candela, G., Tartaglia, E., Gambardella, C., Mauriello, C., Pettinato, G., Bellastella, G., Esposito, K., Santini, L."Leiomyosarcoma of the thyroid gland: A case report and literature review". Oncology Letters 7.4 (2014): 1011-1014.
Chicago
Conzo, G., Candela, G., Tartaglia, E., Gambardella, C., Mauriello, C., Pettinato, G., Bellastella, G., Esposito, K., Santini, L."Leiomyosarcoma of the thyroid gland: A case report and literature review". Oncology Letters 7, no. 4 (2014): 1011-1014. https://doi.org/10.3892/ol.2014.1853
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