Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib

  • Authors:
    • Douglas Vivona
    • Luciene Terezina Lima
    • Alice Cristina Rodrigues
    • Carolina Tosin Bueno
    • Greyce Kelly Steinhorst Alcantara
    • Luiza Saldanha Ribeiro Barros
    • Vania Tiestsche De Moraes Hungria
    • Carlos Sérgio Chiattone
    • Maria De Lourdes Lopes Ferrari Chauffaille
    • Elvira Maria Guerra‑Shinohara
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Science, University of São Paulo, São Paulo 05508‑900, Brazil, Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508‑900, Brazil, Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Science, University of São Paulo, Ribeirão Preto 14040‑903, Brazil, Department of Hematology and Hemotherapy, Santa Casa Medical School, São Paulo 01223-001, Brazil, Department of Clinical and Experimental Oncology, Federal University of São Paulo, São Paulo 04023-900, Brazil
  • Pages: 1313-1319
    |
    Published online on: February 7, 2014
       https://doi.org/10.3892/ol.2014.1857
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Despite the high efficacy of imatinib mesylate (IM) treatment for chronic myeloid leukemia (CML) patients, some individuals develop resistance due to impaired bioavailability. It has been previously demonstrated that the haplotypes for ATP‑binding cassette subfamily B member 1 (ABCB1)with c.1236C>T, c.3435C>T and c.2677G>T/A polymorphisms markedly affect the secondary structure of ABCB1 mRNA and its activity. These modifications may affect efflux transporter activity and response to treatment with IM. The aim of the present study was to investigate the influence of ABCB1 haplotypes on P‑glycoprotein (P‑gp) activity, IM plasma levels and IM response. In total, 28 chronic‑phase CML patients treated with a standard dose of IM (400 mg/day) were studied. The patients were selected according to the haplotypes of ABCB1, with c.1236C>T, c.3435C>T and c.2677G>T polymorphisms, and were classified into two groups based on the presence of the mutated allele in each genotype for the three ABCB1 polymorphisms. In addition, expression of P‑gp and breakpoint cluster region‑abelson 1 (BCR‑ABL1), ABCB1 and solute carrier family 22 member 1 (SLC22A1) mRNA were evaluated. The P‑gp activity in the wild‑type group was found to be higher than that in the mutated group (59.1 vs. 38.3%; P=0.001). Furthermore, the patients who did not achieve major molecular response (MMR) showed a higher rate of efflux mediated by P‑gp when compared with individuals who achieved MMR (64.7 vs. 45.7%; P=0.001). All patients without MMR demonstrated effluxes of >60%. In addition, patients without MMR exhibited lower plasma concentrations of IM compared with those with MMR (0.51 vs. 1.42 µg/ml; P=0.001). Higher levels of SLC22A1 mRNA were observed in patients who achieved MMR and complete molecular response (P<0.05). In conclusion, the ABCB1 1236CT/3435CT/2677GT and 1236TT/3435TT/2677TT haplotypes are associated with reduced P‑gp activity and MMR in chronic‑phase CML patients treated with a standard dose of IM.
View Figures

Figure 1

Figure 2

View References

1 

Thanopoulou E and Judson I: The safety profile of imatinib in CML and GIST: long-term considerations. Arch Toxicol. 86:1–12. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Druker BJ and Lydon NB: Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest. 105:3–7. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Deininger MOBS, Guilhot F, Goldman JM, Hochhaus A, Hughes TP, Radich JP, Hatfield AK, Mone M, Filian J, Reynolds J, Gathmann I, Larson RA and Druker BJ: International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. Blood (ASH Annual Meeting Abstracts). 114:4622009.

4 

Branford S, Rudzki Z, Walsh S, et al: High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood. 99:3472–3475. 2002. View Article : Google Scholar

5 

Eechoute K, Sparreboom A, Burger H, et al: Drug transporters and imatinib treatment: implications for clinical practice. Clin Cancer Res. 17:406–415. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Hegedus T, Orfi L, Seprodi A, Váradi A, Sarkadi B and Kéri G: Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. Biochim Biophys Acta. 1587:318–325. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Hamada A, Miyano H, Watanabe H and Saito H: Interaction of imatinib mesilate with human P-glycoprotein. J Pharmacol Exp Ther. 307:824–828. 2003. View Article : Google Scholar

8 

Thomas J, Wang L, Clark RE and Pirmohamed M: Active transport of imatinib into and out of cells: implications for drug resistance. Blood. 104:3739–3745. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Callen DF, Baker E, Simmers RN, Seshadri R and Roninson IB: Localization of the human multiple-drug resistance gene, MDR1, to 7q21.1. Human Genet. 77:142–144. 1987. View Article : Google Scholar : PubMed/NCBI

10 

Bodor M, Kelly EJ and Ho RJ: Characterization of the human MDR1 gene. AAPS J. 7:E1–E5. 2005. View Article : Google Scholar

11 

Fletcher JI, Haber M, Henderson MJ and Norris MD: ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer. 10:147–156. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Fung KL and Gottesman MM: A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta. 1794:860–871. 2009. View Article : Google Scholar

13 

Kimchi-Sarfaty C, Marple AH, Shinar S, et al: Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene. Pharmacogenomics. 8:29–39. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Kimchi-Sarfaty C, Oh JM, Kim IW, et al: A ‘silent’ polymorphism in the MDR1 gene changes substrate specificity. Science. 315:525–528. 2007.

15 

Vivona D, Bueno CT, Lima LT, et al: ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib. Blood Cells Mol Dis. 48:132–136. 2012. View Article : Google Scholar

16 

Rodrigues AC, Rebecchi IM, Bertolami MC, Faludi AA, Hirata MH and Hirata RD: High baseline serum total and LDL cholesterol levels are associated with MDR1 haplotypes in Brazilian hypercholesterolemic individuals of European descent. Braz J Med Biol Res. 38:1389–1397. 2005. View Article : Google Scholar

17 

Cascorbi I, Gerloff T, Johne A, et al: Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther. 69:169–174. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Branford S and Hughes T: Diagnosis and monitoring of chronic myeloid leukemia by qualitative and quantitative RT-PCR. Methods Mol Med. 125:69–92. 2006.PubMed/NCBI

19 

Vandesompele J, De Preter K, Pattyn F, et al: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3:RESEARCH00342002. View Article : Google Scholar

20 

Albermann N, Schmitz-Winnenthal FH, Z’graggen K, et al: Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem Pharmacol. 70:949–958. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Rodrigues AC, Curi R, Britto LR, et al: Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells. Biochim Biophys Acta. 1760:1866–1873. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Larson RA, Druker BJ, Guilhot F, et al: Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study. Blood. 111:4022–4028. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Ajimura TO, Borges KB, Ferreira AF, de Castro FA and de Gaitani CM: Capillary electrophoresis method for plasmatic determination of imatinib mesylate in chronic myeloid leukemia patients. Electrophoresis. 32:1885–1892. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Jamroziak K, Młynarski W, Balcerczak E, et al: Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia. Eur J Haematol. 72:314–321. 2004. View Article : Google Scholar

25 

Shitara K, Matsuo K, Ito S, et al: Effects of genetic polymorphisms in the ABCB1 gene on clinical outcomes in patients with gastric cancer treated by second-line chemotherapy. Asian Pac J Cancer Prev. 11:447–452. 2010.

26 

Deenen MJ, Cats A, Beijnen JH and Schellens JH: Part 2: pharmacogenetic variability in drug transport and phase I anticancer drug metabolism. Oncologist. 16:820–834. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Dulucq S, Bouchet S, Turcq B, et al: Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood. 112:2024–2027. 2008. View Article : Google Scholar

28 

Hung CC, Tai JJ, Lin CJ, Lee MJ and Liou HH: Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response. Pharmacogenomics. 6:411–417. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Wong M, Evans S, Rivory LP, et al: Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clin Pharmacol Ther. 77:33–42. 2005. View Article : Google Scholar

30 

Aarnoudse AJ, Dieleman JP, Visser LE, et al: Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration. Pharmacogenet Genomics. 18:299–305. 2008. View Article : Google Scholar

31 

Keskitalo JE, Kurkinen KJ, Neuvoneni PJ and Niemi M: ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin. Clin Pharmacol Ther. 84:457–461. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Xu P, Jiang ZP, Zhang BK, Tu JY and Li HD: Impact of MDR1 haplotypes derived from C1236T, G2677T/A and C3435T on the pharmacokinetics of single-dose oral digoxin in healthy Chinese volunteers. Pharmacology. 82:221–227. 2008. View Article : Google Scholar

33 

Wu H, Kang H, Liu Y, et al: Roles of ABCB1 gene polymorphisms and haplotype in susceptibility to breast carcinoma risk and clinical outcomes. J Cancer Res Clin Oncol. 138:1449–1462. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Kim RB, Leake BF, Choo EF, et al: Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther. 70:189–199. 2001. View Article : Google Scholar

35 

Tapaninen T, Neuvonen PJ and Niemi M: Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren. Eur J Clin Pharmacol. 66:865–870. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Jensen BP, Roberts RL, Vyas R, Bonke G, Jardine DL and Begg EJ: Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers. Br J Clin Pharmacol. 73:619–628. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Marsh S, Paul J, King CR, Gifford G, McLeod HL and Brown R: Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer. J Clin Oncol. 25:4528–4535. 2007. View Article : Google Scholar

38 

Picard S, Titier K, Etienne G, et al: Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood. 109:3496–3499. 2007. View Article : Google Scholar

39 

Marin D, Bazeos A, Mahon FX, et al: Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol. 28:2381–2388. 2010. View Article : Google Scholar

40 

Takahashi N, Wakita H, Miura M, et al: Correlation between imatinib pharmacokinetics and clinical response in Japanese patients with chronic-phase chronic myeloid leukemia. Clin Pharmacol Ther. 88:809–813. 2010. View Article : Google Scholar

41 

Yamakawa Y, Hamada A, Nakashima R, et al: Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 33:244–250. 2011.PubMed/NCBI

42 

Gurney H, Wong M, Balleine RL, et al: Imatinib disposition and ABCB1 (MDR1, P-glycoprotein) genotype. Clin Pharmacol Ther. 82:33–40. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Dey S: Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition. Expert Opin Drug Deliv. 3:23–35. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Rautio J, Humphreys JE, Webster LO, et al: In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates. Drug Metab Dispos. 34:786–792. 2006. View Article : Google Scholar

45 

Hoffmeyer S, Burk O, von Richter O, et al: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA. 97:3473–3478. 2000. View Article : Google Scholar

46 

Tsai CJ, Sauna ZE, Kimchi-Sarfaty C, Ambudkar SV, Gottesman MM and Nussinov R: Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima. J Mol Biol. 383:281–291. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Vivona D, Lima LT, Rodrigues AC, Bueno CT, Alcantara GK, Barros LS, Hungria VT, Chiattone CS, Chauffaille MD, Guerra‑Shinohara EM, Guerra‑Shinohara EM, et al: ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib. Oncol Lett 7: 1313-1319, 2014.
APA
Vivona, D., Lima, L.T., Rodrigues, A.C., Bueno, C.T., Alcantara, G.K., Barros, L.S. ... Guerra‑Shinohara, E.M. (2014). ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib. Oncology Letters, 7, 1313-1319. https://doi.org/10.3892/ol.2014.1857
MLA
Vivona, D., Lima, L. T., Rodrigues, A. C., Bueno, C. T., Alcantara, G. K., Barros, L. S., Hungria, V. T., Chiattone, C. S., Chauffaille, M. D., Guerra‑Shinohara, E. M."ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib". Oncology Letters 7.4 (2014): 1313-1319.
Chicago
Vivona, D., Lima, L. T., Rodrigues, A. C., Bueno, C. T., Alcantara, G. K., Barros, L. S., Hungria, V. T., Chiattone, C. S., Chauffaille, M. D., Guerra‑Shinohara, E. M."ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib". Oncology Letters 7, no. 4 (2014): 1313-1319. https://doi.org/10.3892/ol.2014.1857
Copy and paste a formatted citation
x
Spandidos Publications style
Vivona D, Lima LT, Rodrigues AC, Bueno CT, Alcantara GK, Barros LS, Hungria VT, Chiattone CS, Chauffaille MD, Guerra‑Shinohara EM, Guerra‑Shinohara EM, et al: ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib. Oncol Lett 7: 1313-1319, 2014.
APA
Vivona, D., Lima, L.T., Rodrigues, A.C., Bueno, C.T., Alcantara, G.K., Barros, L.S. ... Guerra‑Shinohara, E.M. (2014). ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib. Oncology Letters, 7, 1313-1319. https://doi.org/10.3892/ol.2014.1857
MLA
Vivona, D., Lima, L. T., Rodrigues, A. C., Bueno, C. T., Alcantara, G. K., Barros, L. S., Hungria, V. T., Chiattone, C. S., Chauffaille, M. D., Guerra‑Shinohara, E. M."ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib". Oncology Letters 7.4 (2014): 1313-1319.
Chicago
Vivona, D., Lima, L. T., Rodrigues, A. C., Bueno, C. T., Alcantara, G. K., Barros, L. S., Hungria, V. T., Chiattone, C. S., Chauffaille, M. D., Guerra‑Shinohara, E. M."ABCB1 haplotypes are associated with P‑gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib". Oncology Letters 7, no. 4 (2014): 1313-1319. https://doi.org/10.3892/ol.2014.1857
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team