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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-April Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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2014-April Volume 7 Issue 4

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Article

microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer

  • Authors:
    • Deyao Wu
    • Yunfeng Zhou
    • Huixing Pan
    • Jian Zhou
    • Yuanfeng Fan
    • Ping Qu

  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu 224001, P.R. China
  • Pages: 1219-1224
    |
    Published online on: February 12, 2014
       https://doi.org/10.3892/ol.2014.1875
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Abstract

The expression of microRNA‑99a (miRNA‑99a) has been investigated in a number of human cancers. It has been reported to be downregulated in several types of cancer, including ovarian carcinoma, squamous cell carcinoma of the tongue, squamous cell lung carcinoma, hepatocellular carcinoma, bladder cancer, prostate cancer and childhood adrenocortical tumors. In the present study, the effects of miRNA‑99a on bladder cancer cell proliferation, migration and invasion were examined. Following transfection of miRNA‑99a, cell viability, cell migration assay, cell invasion, western blot analysis and luciferase assays were conducted in bladder cancer cell lines. It was found that miRNA‑99a inhibits cell proliferation, migration and invasion in T24 and EJ cells. Additionally, this study provided the first evidence that miRNA‑99a is likely to directly target fibroblast growth factor receptor 3 in bladder cancer. The study provided evidence that miRNA‑99a suppresses cell proliferation, migration and invasion by targeting growth factor receptor 3 in bladder cancer cell lines. These results indicated that it could be investigated as a target for therapeutic drugs designed to treat bladder cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Wu D, Zhou Y, Pan H, Zhou J, Fan Y and Qu P: microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer. Oncol Lett 7: 1219-1224, 2014.
APA
Wu, D., Zhou, Y., Pan, H., Zhou, J., Fan, Y., & Qu, P. (2014). microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer. Oncology Letters, 7, 1219-1224. https://doi.org/10.3892/ol.2014.1875
MLA
Wu, D., Zhou, Y., Pan, H., Zhou, J., Fan, Y., Qu, P."microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer". Oncology Letters 7.4 (2014): 1219-1224.
Chicago
Wu, D., Zhou, Y., Pan, H., Zhou, J., Fan, Y., Qu, P."microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer". Oncology Letters 7, no. 4 (2014): 1219-1224. https://doi.org/10.3892/ol.2014.1875
Copy and paste a formatted citation
x
Spandidos Publications style
Wu D, Zhou Y, Pan H, Zhou J, Fan Y and Qu P: microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer. Oncol Lett 7: 1219-1224, 2014.
APA
Wu, D., Zhou, Y., Pan, H., Zhou, J., Fan, Y., & Qu, P. (2014). microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer. Oncology Letters, 7, 1219-1224. https://doi.org/10.3892/ol.2014.1875
MLA
Wu, D., Zhou, Y., Pan, H., Zhou, J., Fan, Y., Qu, P."microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer". Oncology Letters 7.4 (2014): 1219-1224.
Chicago
Wu, D., Zhou, Y., Pan, H., Zhou, J., Fan, Y., Qu, P."microRNA‑99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer". Oncology Letters 7, no. 4 (2014): 1219-1224. https://doi.org/10.3892/ol.2014.1875
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