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Article

TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder

  • Authors:
    • Ziru Liu
    • Zhulin Yang
    • Dongcai Liu
    • Daiqiang Li
    • Qiong Zou
    • Yuan Yuan
    • Jinghe Li
    • Lufeng Liang
    • Meigui Chen
    • Senlin Chen
  • View Affiliations / Copyright

    Affiliations: Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Pathology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Pathology, Basic School of Medicine, Central South University, Changsha, Hunan 410078, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People's Hospital, Changsha, Hunan 410007, P.R. China, Department of Pathology, Loudi Central Hospital, Loudi, Hunan 417011, P.R. China, Department of Pathology, Hunan Provincial Tumor Hospital, Changsha, Hunan 410013, P.R. China
  • Pages: 1128-1138
    |
    Published online on: February 14, 2014
       https://doi.org/10.3892/ol.2014.1886
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Abstract

The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and paternally expressed gene (PEG) 10 was assessed in 46 SC/ASCs and 80 adenocarcinomas (ACs) using immunohistochemistry, and the samples were further analyzed to examine correlations with the clinicopathological characteristics. It was demonstrated that positive TSG101 and PEG10 expression were significantly associated with large tumor size, high tumor‑node‑metastasis (TNM) stage, lymph node metastasis, invasion and no resection (only biopsy) of SC/ASC and AC. The univariate Kaplan‑Meier analysis showed that positive TSG101 and PEG10 expression, and differentiation, tumor size, TNM stage, lymph node metastasis, invasion and surgical curability, is closely associated with a decreased overall survival in SC/ASC and AC patients (P<0.05 or P<0.001). The multivariate Cox regression analysis identified that positive TSG101 and PEG10 expression are independent factors for a poor‑prognosis in SC/ASC and AC patients. The present study indicates that positive TSG101 and PEG10 expression are closely associated with the clinical, pathological and biological behaviors, and a poor prognosis in gallbladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Yang Z, Liu D, Li D, Zou Q, Yuan Y, Li J, Liang L, Chen M, Chen S, Chen S, et al: TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. Oncol Lett 7: 1128-1138, 2014.
APA
Liu, Z., Yang, Z., Liu, D., Li, D., Zou, Q., Yuan, Y. ... Chen, S. (2014). TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. Oncology Letters, 7, 1128-1138. https://doi.org/10.3892/ol.2014.1886
MLA
Liu, Z., Yang, Z., Liu, D., Li, D., Zou, Q., Yuan, Y., Li, J., Liang, L., Chen, M., Chen, S."TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder". Oncology Letters 7.4 (2014): 1128-1138.
Chicago
Liu, Z., Yang, Z., Liu, D., Li, D., Zou, Q., Yuan, Y., Li, J., Liang, L., Chen, M., Chen, S."TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder". Oncology Letters 7, no. 4 (2014): 1128-1138. https://doi.org/10.3892/ol.2014.1886
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Yang Z, Liu D, Li D, Zou Q, Yuan Y, Li J, Liang L, Chen M, Chen S, Chen S, et al: TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. Oncol Lett 7: 1128-1138, 2014.
APA
Liu, Z., Yang, Z., Liu, D., Li, D., Zou, Q., Yuan, Y. ... Chen, S. (2014). TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. Oncology Letters, 7, 1128-1138. https://doi.org/10.3892/ol.2014.1886
MLA
Liu, Z., Yang, Z., Liu, D., Li, D., Zou, Q., Yuan, Y., Li, J., Liang, L., Chen, M., Chen, S."TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder". Oncology Letters 7.4 (2014): 1128-1138.
Chicago
Liu, Z., Yang, Z., Liu, D., Li, D., Zou, Q., Yuan, Y., Li, J., Liang, L., Chen, M., Chen, S."TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder". Oncology Letters 7, no. 4 (2014): 1128-1138. https://doi.org/10.3892/ol.2014.1886
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