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Article

MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy

  • Authors:
    • Louqiang Zhang
    • Longjiang Li
    • Yin Wang
    • Ying Liu
    • Chunjie Li
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 1569-1575
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    Published online on: February 21, 2014
       https://doi.org/10.3892/ol.2014.1902
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Abstract

Mucoepidermoid carcinoma (MEC) is common in human salivary glands. Surgery is the preferred treatment method for MEC and chemotherapy is often administered following surgery as an adjuvant cancer treatment; however, chemotherapy does not completely prevent tumor recurrence. Emerging evidence has indicated the existence of cancer stem‑like (CSL)‑cells in tumors. CSL‑cells are important in the development, invasion and drug resistance of carcinomas. The present study aimed to investigate whether chemotherapy enriched the CSL-cells in the MEC cell line of MC3 using 5-fluorouracil (5-Fu). The MC3 cells were treated with 5‑Fu, which enhanced the spherogenesis and vitality of the cells and upregulated the pluripotency gene, octamer‑binding transcription factor 4. Side population analysis demonstrated that the proportion of CSL‑cells also increased. These findings showed that compared with other types of cancer cells, chemotherapy was unable to effectively kill the CSL‑cells resulting in an enriched CSL‑cell subpopulation with a higher resistance to chemotherapy, which may have been key the recurrence of MEC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Li L, Wang Y, Liu Y and Li C: MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy. Oncol Lett 7: 1569-1575, 2014.
APA
Zhang, L., Li, L., Wang, Y., Liu, Y., & Li, C. (2014). MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy. Oncology Letters, 7, 1569-1575. https://doi.org/10.3892/ol.2014.1902
MLA
Zhang, L., Li, L., Wang, Y., Liu, Y., Li, C."MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy". Oncology Letters 7.5 (2014): 1569-1575.
Chicago
Zhang, L., Li, L., Wang, Y., Liu, Y., Li, C."MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy". Oncology Letters 7, no. 5 (2014): 1569-1575. https://doi.org/10.3892/ol.2014.1902
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Li L, Wang Y, Liu Y and Li C: MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy. Oncol Lett 7: 1569-1575, 2014.
APA
Zhang, L., Li, L., Wang, Y., Liu, Y., & Li, C. (2014). MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy. Oncology Letters, 7, 1569-1575. https://doi.org/10.3892/ol.2014.1902
MLA
Zhang, L., Li, L., Wang, Y., Liu, Y., Li, C."MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy". Oncology Letters 7.5 (2014): 1569-1575.
Chicago
Zhang, L., Li, L., Wang, Y., Liu, Y., Li, C."MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy". Oncology Letters 7, no. 5 (2014): 1569-1575. https://doi.org/10.3892/ol.2014.1902
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