MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy

  • Authors:
    • Louqiang Zhang
    • Longjiang Li
    • Yin Wang
    • Ying Liu
    • Chunjie Li
  • View Affiliations

  • Published online on: February 21, 2014     https://doi.org/10.3892/ol.2014.1902
  • Pages: 1569-1575
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mucoepidermoid carcinoma (MEC) is common in human salivary glands. Surgery is the preferred treatment method for MEC and chemotherapy is often administered following surgery as an adjuvant cancer treatment; however, chemotherapy does not completely prevent tumor recurrence. Emerging evidence has indicated the existence of cancer stem‑like (CSL)‑cells in tumors. CSL‑cells are important in the development, invasion and drug resistance of carcinomas. The present study aimed to investigate whether chemotherapy enriched the CSL-cells in the MEC cell line of MC3 using 5-fluorouracil (5-Fu). The MC3 cells were treated with 5‑Fu, which enhanced the spherogenesis and vitality of the cells and upregulated the pluripotency gene, octamer‑binding transcription factor 4. Side population analysis demonstrated that the proportion of CSL‑cells also increased. These findings showed that compared with other types of cancer cells, chemotherapy was unable to effectively kill the CSL‑cells resulting in an enriched CSL‑cell subpopulation with a higher resistance to chemotherapy, which may have been key the recurrence of MEC.
View Figures
View References

Related Articles

Journal Cover

May-2014
Volume 7 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Li L, Wang Y, Liu Y and Li C: MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy. Oncol Lett 7: 1569-1575, 2014
APA
Zhang, L., Li, L., Wang, Y., Liu, Y., & Li, C. (2014). MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy. Oncology Letters, 7, 1569-1575. https://doi.org/10.3892/ol.2014.1902
MLA
Zhang, L., Li, L., Wang, Y., Liu, Y., Li, C."MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy". Oncology Letters 7.5 (2014): 1569-1575.
Chicago
Zhang, L., Li, L., Wang, Y., Liu, Y., Li, C."MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy". Oncology Letters 7, no. 5 (2014): 1569-1575. https://doi.org/10.3892/ol.2014.1902