Association of interleukin‑10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma

  • Authors:
    • Jian Zhou
    • Duo Zhang
    • Bin Chen
    • Qing Li
    • Lin Zhou
    • Fei Liu
    • Kuang‑Yen Chou
    • Lei Tao
    • Li‑Ming Lu
  • View Affiliations

  • Published online on: February 26, 2014     https://doi.org/10.3892/ol.2014.1914
  • Pages: 1721-1727
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Abstract

Interleukin (IL)‑10 is critically involved in tumorigenesis. In the present study, the association between the IL‑10 ‑1082/‑819/‑592 promoter polymorphisms, the plasma IL‑10 levels and the risk of laryngeal squamous cell carcinoma (LSCC) was investigated in a prospective, case‑control study. In total, 146 patients with LSCC, 61 with vocal leukoplakia and 119 healthy controls were genotyped for the IL‑10 gene (IL‑10 ‑1082 A/G, ‑819 T/C and ‑592 A/C) using pyrosequencing, and their plasma IL‑10 levels were analyzed by ELISA. The patients with LSCC had a significantly higher frequency of AC at position ‑592 and ‑819 (OR, 1.82 and P=0.024) compared with the control, and a higher frequency of AG at position ‑1082 (OR, 2.20 and P=0.037). The patients with advanced LSCC had a significantly higher frequency of AG+GG at position ‑1082 compared with those with early‑stage LSCC (OR, 3.13 and P=0.008 vs. OR, 2.06 and P=0.068). The patients with lymph node metastasis had a significantly higher frequency of AG+GG at position ‑1082 compared with the patients with no lymph node metastasis (OR, 2.97 and P=0.048 vs. OR, 2.23 and P=0.035). In addition, the patients with high frequencies of each genotype polymorphism had high plasma IL‑10 concentrations. The present study indicates that the IL‑10 ‑1082/‑819/‑592 promoter polymorphisms and corresponding high plasma IL‑10 concentrations are associated with LSCC, and that variations in genotype distribution and plasma IL‑10 concentrations may be associated with the stage and the lymph node metastasis status of LSCC.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou J, Zhang D, Chen B, Li Q, Zhou L, Liu F, Chou KY, Tao L and Lu LM: Association of interleukin‑10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma. Oncol Lett 7: 1721-1727, 2014
APA
Zhou, J., Zhang, D., Chen, B., Li, Q., Zhou, L., Liu, F. ... Lu, L. (2014). Association of interleukin‑10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma. Oncology Letters, 7, 1721-1727. https://doi.org/10.3892/ol.2014.1914
MLA
Zhou, J., Zhang, D., Chen, B., Li, Q., Zhou, L., Liu, F., Chou, K., Tao, L., Lu, L."Association of interleukin‑10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma". Oncology Letters 7.5 (2014): 1721-1727.
Chicago
Zhou, J., Zhang, D., Chen, B., Li, Q., Zhou, L., Liu, F., Chou, K., Tao, L., Lu, L."Association of interleukin‑10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma". Oncology Letters 7, no. 5 (2014): 1721-1727. https://doi.org/10.3892/ol.2014.1914