Primary anorectal malignant melanoma treated with neoadjuvant chemoradiotherapy and sphincter‑sparing surgery: A case report

Su,Meng; Zhu,Lucheng; Luo,Wenhua; Wei,Hangping; Zou,Changlin

doi:10.3892/ol.2014.1925

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Case Report

Primary anorectal malignant melanoma treated with neoadjuvant chemoradiotherapy and sphincter‑sparing surgery: A case report

Authors:
- Meng Su
- Lucheng Zhu
- Wenhua Luo
- Hangping Wei
- Changlin Zou
View Affiliations / Copyright

Affiliations: Department of Radio‑Chemotherapy Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
Pages: 1605-1607
|
Published online on: February 28, 2014

https://doi.org/10.3892/ol.2014.1925
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Abstract

Primary anorectal (PA) malignant melanoma (MM) is a rare disease associated with a high mortality rate. The most appropriate treatment strategy for PAMM remains controversial. A 55‑year‑old female patient, who was misdiagnosed with locally advanced rectal carcinoma, was treated with preoperative radiotherapy and concurrent oral capecitabine. During the therapy, grade 1 leukopenia occurred, however, there was no interruption to treatment. Following chemoradiotherapy, a computer tomography scan identified that the tumor had shrunk significantly and the original enlarged lymph nodes had disappeared. Eight weeks after completion of chemoradiotherapy, sphincter‑sparing surgery was performed on the patient and based on the postoperative pathological result, MM was diagnosed. At the time of writing, the patient has survived disease‑free for 15 months and at the most recent follow‑up examination the Karnofsky Performance Scale score was 100. The therapeutic regimen of neoadjuvant concurrent chemoradiotherapy together with sphincter‑sparing surgery is considered to be an optimal choice for patients with PAMM. However, further studies are required to evaluate the efficacy and clinical utility of this therapeutic regimen.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary anorectal malignant melanoma treated with neoadjuvant chemoradiotherapy and sphincter‑sparing surgery: A case report

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