Effects of 14 frequently used drugs on prostate‑specific antigen expression in prostate cancer LNCaP cells

Iguchi,Kazuhiro; Hashimoto,Maki; Kubota,Masafumi; Yamashita,Shuji; Nakamura,Mitsuhiro; Usui,Shigeyuki; Sugiyama,Tadashi; Hirano,Kazuyuki

doi:10.3892/ol.2014.1936

May-2014 Volume 7 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2014 Volume 7 Issue 5

Full Size Image

Article

Effects of 14 frequently used drugs on prostate‑specific antigen expression in prostate cancer LNCaP cells

Authors:
- Kazuhiro Iguchi
- Maki Hashimoto
- Masafumi Kubota
- Shuji Yamashita
- Mitsuhiro Nakamura
- Shigeyuki Usui
- Tadashi Sugiyama
- Kazuyuki Hirano
View Affiliations / Copyright

Affiliations: Laboratory of Drug Metabolism and Pharmacokinetics, Gifu Pharmaceutical University, Gifu 501‑1196, Japan, Laboratory of Community Pharmaceutics, Gifu Pharmaceutical University, Gifu 501‑1196, Japan, Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu 501‑1196, Japan, Laboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu 501‑1196, Japan
Pages: 1665-1668
|
Published online on: March 5, 2014

https://doi.org/10.3892/ol.2014.1936
Expand metrics +

Abstract

Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate‑specific antigen (PSA), a widely used prostate cancer marker, are influenced by a number of drugs, such as non‑steroidal anti‑inflammatory drugs and statins. In the present study, the drugs prescribed to patients on a repeat prescription collected at the pharmacy of the Gifu Pharmaceutical University (Gifu, Japan) were examined for their effects on the levels of PSA expression in prostate cancer LNCaP cells. Among the 14 drugs investigated, betamethasone, an agonist of the glucocorticoid receptor, was found to increase the levels of PSA mRNA expression in the LNCaP cells. This betamethasone‑induced expression was mediated, at least in part, through androgen receptor (AR) transcriptional activation. Dexamethasone, a typical agonist of the glucocorticoid receptor, was also found to stimulate the AR transcriptional activity, however, to a lesser extent than betamethasone. Therefore, it would be interesting to examine in future studies whether the serum PSA levels in prostate cancer patients are influenced by betamethasone.

View Figures

View References

1	Mochtar CA and Andika RS: The value of prostate-specific antigen in Asia. Ther Adv Urol. 2:77–83. 2010. View Article : Google Scholar
2	Fowke JH, Motley SS, Barocas DA, et al: The associations between statin use and prostate cancer screening, prostate size, high-grade prostatic intraepithelial neoplasia (PIN), and prostate cancer. Cancer Causes Control. 22:417–426. 2011. View Article : Google Scholar
3	Hamilton RJ, Banez LL, Aronson WJ, et al: Statin medication use and the risk of biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database. Cancer. 116:3389–3398. 2008. View Article : Google Scholar
4	Murad AS, Down L, Davey Smith G, et al: Associations of aspirin, nonsteroidal anti-inflammatory drug and paracetamol use with PSA-detected prostate cancer: findings from a large, population-based, case-control study (the ProtecT study). Int J Cancer. 128:1442–1448. 2011. View Article : Google Scholar
5	Chang SL, Harshman LC and Presti JC Jr: Impact of common medications on serum total prostate-specific antigen levels: analysis of the National Health and Nutrition Examination Survey. J Clin Oncol. 28:3951–3957. 2010. View Article : Google Scholar
6	Iguchi K, Toyama T, Ito T, et al: Antiandrogenic activity of resveratrol analogs in prostate cancer LNCaP cells. J Andrology. 33:1208–1215. 2012. View Article : Google Scholar : PubMed/NCBI
7	Iguchi K, Hayakawa Y, Ishii K, et al: Characterization of the low pH/low nutrient-resistant LNCaP cell subline LNCaP-F10. Oncol Rep. 28:2009–2015. 2012.PubMed/NCBI
8	Berrevoets CA, Veldscholte J and Mulder E: Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors. J Steroid Biochem Mol Biol. 46:731–736. 1993. View Article : Google Scholar
9	Otsuka T, Iguchi K, Fukami K, et al: Androgen receptor W741C and T877A mutations in AIDL cells, an androgen-independent subline of prostate cancer LNCaP cells. Tumour Biol. 32:1097–1102. 2011. View Article : Google Scholar
10	Chang CY, Walther PJ and McDonnell DP: Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. Cancer Res. 61:8712–8717. 2001.
11	Koochekpour S: Androgen receptor signaling and mutations in prostate cancer. Asian J Andrology. 12:639–657. 2010. View Article : Google Scholar : PubMed/NCBI
12	Kassi E and Moutsatsou P: Glucocorticoid receptor signaling and prostate cancer. Cancer Lett. 302:1–10. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of 14 frequently used drugs on prostate‑specific antigen expression in prostate cancer LNCaP cells

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles