Achievement of three year remission in a case of aggressive glioblastoma using a multidisciplinary treatment strategy: A case report

Ishida,Atsushi; Watanabe,Mika; Matsuo,Seigo; Niimura,Kaku; Yoshimoto,Haruko; Asakuno,Keizoh; Shiramizu,Hideki; Nemoto,Akio; Yuzawa,Miki; Hori,Tomokatsu

doi:10.3892/ol.2014.1937

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Case Report

Achievement of three year remission in a case of aggressive glioblastoma using a multidisciplinary treatment strategy: A case report

Authors:
- Atsushi Ishida
- Mika Watanabe
- Seigo Matsuo
- Kaku Niimura
- Haruko Yoshimoto
- Keizoh Asakuno
- Hideki Shiramizu
- Akio Nemoto
- Miki Yuzawa
- Tomokatsu Hori
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Moriyama Memorial Hospital, Tokyo 134‑8608, Japan, Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980‑8575, Japan
Pages: 1608-1612
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Published online on: March 5, 2014

https://doi.org/10.3892/ol.2014.1937
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Abstract

Glioblastoma (GB) is the most common type of malignant tumor of the central nervous system and, despite extensive research, its prognosis is poor. Although recent advances have been made in the treatment of GB with aggressive resection combined with radiochemotherapy, more than three‑quarters of GB patients succumb to the disease within two years. The current study presents a highly aggressive case of small cell GB as diagnosed by histological features and immunohistochemistry for vimentin, glial fibrillary acidic protein, oligodendrocyte lineage transcription factor 2, isocitrate dehydrogenase 1‑R132H and p53. The patient was treated using a multidisciplinary treatment strategy, which included temozolomide, CyberKnife radiotherapy and autologous formalin‑fixed tumor vaccination. In addition, the patient developed radiation necrosis, which was treated with bevacizumab. In conclusion, three years following the initial diagnosis, the patient continues to experience a successful clinical course, and the observations of the current study demonstrate that a multidisciplinary treatment strategy may be effective for the treatment of aggressive GB.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Achievement of three year remission in a case of aggressive glioblastoma using a multidisciplinary treatment strategy: A case report

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