Primary Burkitt's lymphoma of the thyroid without Epstein‑Barr virus infection: A case report and literature review

Zhang,Liying; Gao,Lanxiang; Liu,Guang; Wang,Luping; Xu,Chunwei; Li,Lin; Tian,Yuwang; Feng,Huiru; Guo,Zhe

doi:10.3892/ol.2014.1941

Primary Burkitt's lymphoma of the thyroid without Epstein‑Barr virus infection: A case report and literature review

Authors:
- Liying Zhang
- Lanxiang Gao
- Guang Liu
- Luping Wang
- Chunwei Xu
- Lin Li
- Yuwang Tian
- Huiru Feng
- Zhe Guo
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Affiliations: Department of Pathology, The Military General Hospital of Beijing PLA, Beijing 100700, P.R. China, Department of Pathology, The Military General Hospital of Beijing PLA, Beijing 100700, P.R. China, Department of Nuclear Medicine, The Military General Hospital of Beijing PLA, Beijing 100700, P.R. China, Department of Nuclear Medicine, The Military General Hospital of Beijing PLA, Beijing 100700, P.R. China
Published online on: March 5, 2014 https://doi.org/10.3892/ol.2014.1941
Pages: 1519-1524

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Abstract

Primary thyroid lymphomas are rare, and the majority are B‑cell lymphoma. Primary Burkitt's lymphoma (BL) of the thyroid is much less common than the other types of lymphoma. The current study presents the case of an eight‑year‑old male with a mass in the right lobe of the thyroid, which was detected by B‑ultrasound. The patient was diagnosed with BL by immunohistochemistry, fluorescence in situ hybridization analysis of MYC (8q24) and immunoglobulin rearrangement assays. Furthermore, subsequent positron emission tomography‑computed tomography scans revealed no abnormal metabolites in the left lobe of the thyroid or in other parts of the body following surgery. The patient underwent alternate R‑B‑NHL‑BFM‑90‑A and R‑B‑NHL‑BFM‑90‑B treatment for four cycles each following the thyroidectomy. The patient is well and remains free of disease recurrence following almost four years follow‑up. The present study discusses this rare case of primary BL of the thyroid and presents a review of the literature. This case report provides evidence that the immediate diagnosis and treatment of primary Burkitt's lymphoma of the thyroid is likely to improve patient outcome.

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