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Review

Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review)

  • Authors:
    • Jia Yang
    • Jin‑Bo Yue
    • Jing Liu
    • Jin‑Ming Yu
  • View Affiliations / Copyright

    Affiliations: Shandong Cancer Hospital and Institute, Jinan University, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China, Graduate Education Centre of Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
  • Pages: 1755-1760
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    Published online on: March 21, 2014
       https://doi.org/10.3892/ol.2014.1990
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Abstract

Repopulation of tumor cells during radiotherapy is believed to be a significant cause for treatment failure. The phenomenon of tumor repopulation during fractionated radiotherapy was found from clinical observations that identified that the local control rate decreased with a prolonged treatment time. A series of animal experiments with varied overall treatment time and fractionated doses were performed to demonstrate tumor cell repopulation during radiotherapy in various mouse xenograft models. However, conventional detection methods are challenging, as it is difficult to separate viable cells from those destined for apoptosis during fractionated radiotherapy. In essence, the mechanism of tumor repopulation involves the continuing proliferation of clonogenic tumor cells. In vivo imaging, tracking and targeting of the repopulation of these cells has been of clinical interest so as to administer a higher dose to the tumor repopulation regions. Currently, functional imaging methods, including 3'‑deoxy‑3'‑18F‑fluorothymidine positron emission tomography (18F‑FLT PET), are showing promise in assessing the proliferation activity of tumors in vivo. This review mainly focuses on the phenomenon of tumor repopulation during radiotherapy and its conventional and novel detection methods, particularly on the feasibility of 18F‑FLT PET for the detection of tumor‑cell repopulation.
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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Yue JB, Liu J and Yu JM: Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review). Oncol Lett 7: 1755-1760, 2014.
APA
Yang, J., Yue, J., Liu, J., & Yu, J. (2014). Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review). Oncology Letters, 7, 1755-1760. https://doi.org/10.3892/ol.2014.1990
MLA
Yang, J., Yue, J., Liu, J., Yu, J."Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review)". Oncology Letters 7.6 (2014): 1755-1760.
Chicago
Yang, J., Yue, J., Liu, J., Yu, J."Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review)". Oncology Letters 7, no. 6 (2014): 1755-1760. https://doi.org/10.3892/ol.2014.1990
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Yue JB, Liu J and Yu JM: Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review). Oncol Lett 7: 1755-1760, 2014.
APA
Yang, J., Yue, J., Liu, J., & Yu, J. (2014). Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review). Oncology Letters, 7, 1755-1760. https://doi.org/10.3892/ol.2014.1990
MLA
Yang, J., Yue, J., Liu, J., Yu, J."Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review)". Oncology Letters 7.6 (2014): 1755-1760.
Chicago
Yang, J., Yue, J., Liu, J., Yu, J."Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review)". Oncology Letters 7, no. 6 (2014): 1755-1760. https://doi.org/10.3892/ol.2014.1990
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