Trastuzumab monotherapy for bone marrow metastasis of breast cancer: A case report

Xu,Long; Guo,Fang; Song,Shuxi; Zhang,Guojing; Liu,Yongye; Xie,Xiaodong

doi:10.3892/ol.2014.1999

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Case Report

Trastuzumab monotherapy for bone marrow metastasis of breast cancer: A case report

Authors:
- Long Xu
- Fang Guo
- Shuxi Song
- Guojing Zhang
- Yongye Liu
- Xiaodong Xie
View Affiliations / Copyright

Affiliations: Department of Oncology, PLA Cancer Center, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, P.R. China
Pages: 1951-1953
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Published online on: March 24, 2014

https://doi.org/10.3892/ol.2014.1999
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Abstract

The current study presents the case of a 41‑year‑old female patient who received modified radical mastectomy and adjuvant chemotherapy and radiotherapy for infiltrating ductal cancer of the left breast. The pathological stage of the disease was IIA. In addition, the patient was negative for the estrogen and progesterone receptors, and human epidermal growth factor receptor‑2 gene amplification was identified. At one year following surgery, the patient presented with severe pancytopenia and pain at multiple sites all over the body. Furthermore, the patient's Eastern Cooperative Oncology Group performance status score was 3 and numeric rating scale pain score was 8. The bone marrow puncture indicated bone marrow metastatic cancer, and the positron emission tomography/computed tomography (CT) indicated multiple internal organ metastases and osseous metastasis. Chemotherapy treatment posed great risks due to the patient's poor performance status and severe bone marrow suppression. Therefore, trastuzumab monotherapy was administered at a loading dose of 8 mg/kg and a maintenance dose of 6 mg/kg every three weeks. Following four doses of trastuzumab treatment, the patient's performance status significantly improved and the peripheral blood cell counts had returned to within the normal ranges. Taxol was added to the trastuzumab treatment and seven cycles were completed. No metastatic cancer cells were found in the subsequent bone marrow smear test; however, CT showed metastatic foci in the left lung. Furthermore, the enlarged lymph nodes had subsided and the tumor in the right appendix region had decreased in size by 50%. The patient's disease condition was maintained stable for 11 months.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Trastuzumab monotherapy for bone marrow metastasis of breast cancer: A case report

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Abstract

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