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Article

Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis

  • Authors:
    • Konstantinos Papaspyrou
    • Christoph Brochhausen
    • Irene Schmidtmann
    • Kai Fruth
    • Haralampos Gouveris
    • James Kirckpatrick
    • Wolf Mann
    • Juergen Brieger
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Mainz D-55101, Germany, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz D-55101, Germany, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz D-55101, Germany
  • Pages: 2041-2046
    |
    Published online on: March 28, 2014
       https://doi.org/10.3892/ol.2014.2007
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Abstract

Fascin is an actin‑bundling protein that is associated with cellular motility and cancer‑cell invasion. The present study aimed to examine the expression of fascin in head and neck squamous cell carcinoma (HNSCC) and its potential use as a biomarker. In a prospective study with a median follow‑up time of 48.8 months, tumor tissues, adjacent healthy tissues and cervical lymph node metastases were collected from 25 patients and analyzed by immunohistochemistry. The specimens were scored according to the intensity of fascin staining and the percentage of tumor cells stained using a semi‑quantitative scoring approach; the data were analyzed and correlated with clinical follow‑up observations. All of the investigators were blinded to the origin of the specimens. The expression levels of fascin were significantly increased in the tumor tissues (P=0.03) and lymph node metastases (P=0.03) compared with that of the normal tissues. The high expression level of fascin in the tumor tissues was correlated with the N‑status, however, not with overall survival. Therefore, fascin may be a suitable marker for the prediction of regional lymphatic metastasis in HNSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Papaspyrou K, Brochhausen C, Schmidtmann I, Fruth K, Gouveris H, Kirckpatrick J, Mann W and Brieger J: Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis. Oncol Lett 7: 2041-2046, 2014.
APA
Papaspyrou, K., Brochhausen, C., Schmidtmann, I., Fruth, K., Gouveris, H., Kirckpatrick, J. ... Brieger, J. (2014). Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis. Oncology Letters, 7, 2041-2046. https://doi.org/10.3892/ol.2014.2007
MLA
Papaspyrou, K., Brochhausen, C., Schmidtmann, I., Fruth, K., Gouveris, H., Kirckpatrick, J., Mann, W., Brieger, J."Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis". Oncology Letters 7.6 (2014): 2041-2046.
Chicago
Papaspyrou, K., Brochhausen, C., Schmidtmann, I., Fruth, K., Gouveris, H., Kirckpatrick, J., Mann, W., Brieger, J."Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis". Oncology Letters 7, no. 6 (2014): 2041-2046. https://doi.org/10.3892/ol.2014.2007
Copy and paste a formatted citation
x
Spandidos Publications style
Papaspyrou K, Brochhausen C, Schmidtmann I, Fruth K, Gouveris H, Kirckpatrick J, Mann W and Brieger J: Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis. Oncol Lett 7: 2041-2046, 2014.
APA
Papaspyrou, K., Brochhausen, C., Schmidtmann, I., Fruth, K., Gouveris, H., Kirckpatrick, J. ... Brieger, J. (2014). Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis. Oncology Letters, 7, 2041-2046. https://doi.org/10.3892/ol.2014.2007
MLA
Papaspyrou, K., Brochhausen, C., Schmidtmann, I., Fruth, K., Gouveris, H., Kirckpatrick, J., Mann, W., Brieger, J."Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis". Oncology Letters 7.6 (2014): 2041-2046.
Chicago
Papaspyrou, K., Brochhausen, C., Schmidtmann, I., Fruth, K., Gouveris, H., Kirckpatrick, J., Mann, W., Brieger, J."Fascin upregulation in primary head and neck squamous cell carcinoma is associated with lymphatic metastasis". Oncology Letters 7, no. 6 (2014): 2041-2046. https://doi.org/10.3892/ol.2014.2007
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