DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
- Authors:
- Masahiko Kanamori
- Taketoshi Yasuda
- Shigeharu Nogami
- Kayo Suzuki
- Takeshi Hori
View Affiliations
Affiliations: Department of Human Science, University of Toyama, Toyama City, Toyama 930‑0194, Japan, Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930‑0194, Japan
- Published online on: April 3, 2014 https://doi.org/10.3892/ol.2014.2030
-
Pages:
1847-1850
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Abstract
Pleomorphic leiomyosarcoma (P‑LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P‑LMS that arose in the axillary region of a 31‑year‑old male. The results of array‑based comparative genomic hybridization for the primary tumor showed DNA copy number alteration (DCNA) gains of 8ptel, 17ptel and 17q11.2 and losses of 2ptel, 7ptel, 7qtel, 10p15, 12p12‑13.1, 13q14.2‑14.3, 15q25‑26 and Yq11. However, a metastatic lesion showed cytogenetic data different from the primary tumor DCNAs, with only the locus of 17ptel (282M15̸SP6) in common between them. These observations add to the spectrum of DCNAs that have been reported in previous cases of LMS and provide novel cytogenetic data.
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